Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Yenamandra S. Prabhakar"'
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 39:4726-4751
Histone deacetylases are zinc-dependent isoform enzymes and play important role in cellular homeostasis. Among these, HDAC8 is a potential anticancer drug target. To design new inhibitors using protein-ligand energy profiles, an all atom molecular dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bea5a27a214fd85ece3f16ee290abbd
https://doi.org/10.1080/07391102.2020.1780940
https://doi.org/10.1080/07391102.2020.1780940
Autor:
Saroj Verma, Varun Dewaker, Pratik Narain Srivastava, Ajay Kumar Srivastava, Yenamandra S. Prabhakar
Publikováno v:
Journal of biomolecular structuredynamics. 40(24)
Designing an inhibitor having strong affinity in the active site pocket is the cherished goal of structure based drug designing. To achieve this, it is considerably important to predict which structural scaffold is better suited for change to increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c5dd9f0b334863b1374ddad59134b2
https://pubmed.ncbi.nlm.nih.gov/34662251
https://pubmed.ncbi.nlm.nih.gov/34662251
Autor:
Seema Kesar, Sarvesh Paliwal, Achal Mishra, Yenamandra S. Prabhakar, Richa Arya, Satya P. Gupta
Publikováno v:
Letters in Drug Design & Discovery. 16:746-760
Background: β-Site amyloidal precursor protein (APP) cleavage enzyme (BACE-1) is reported as prime cause for progession of Alzheimer’s disease (AD). It is a form of dementia characterized by degeneration of neurones in brain. Therefore, attempts h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::545fb7108074363ddd4d354086d02348
https://doi.org/10.2174/1570180815666180627124422
https://doi.org/10.2174/1570180815666180627124422
Autor:
Amit Mandal, Parthasarathi Bhattacharyya, Anura V Kurpad, Aastha Baliyan, Sudhanshu Vrati, Shubhra Agarwal, Chandru Subramani, Umashankar Velusamy, Padmakar Wagh, Kiran Krishnan, Raghu Tadala, Yenamandra S. Prabhakar, Varun Dewaker, Amrita Mitra, Utsab Debnath
The infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) resulted in a pandemic with huge death toll and economic consequences. The virus attaches itself to the human epithelial cells through noncovalent bonding of its spi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a48b2afad55bf5a3d237bca0a4babaa5
https://doi.org/10.26434/chemrxiv.12687923
https://doi.org/10.26434/chemrxiv.12687923
Autor:
Ruchi Saxena, Vishal Chandra, Murli Manohar, Kanchan Hajela, Utsab Debnath, Yenamandra S Prabhakar, Karan Singh Saini, Rituraj Konwar, Sandeep Kumar, Kaling Megu, Bal Gangadhar Roy, Anila Dwivedi
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66246 (2013)
Inhibition of epidermal growth factor receptor (EGFR) signaling is considered to be a promising treatment strategy for estrogen receptor (ER)-negative breast tumors. We have investigated here the anti-breast cancer properties of a novel anti-prolifer
Externí odkaz:
https://doaj.org/article/6857c3de7aa34bcc9c0118c41f4072ec
Publikováno v:
Journal of Chemistry, Vol 2013 (2013)
The antimalarial activity of a series of 4-anilinoquinolines was modeled with topological and other functional descriptors using feature selection approaches CP-MLR and GA. Five models were identified from each approach to explain the activity of the
Externí odkaz:
https://doaj.org/article/ab5e87745e9449b5888b3104085fbd14
Publikováno v:
Current HIV Research. 16:121-129
Introduction: A possible strategy to combat mutant strains is to have a thorough structural evaluation before and after mutations to identify the diversity in the non-nucleoside inhibitor binding pocket and their effects on enzyme-ligand interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9407fa0df7a32150443524bc5fadd5
https://doi.org/10.2174/1570162x16666180412165004
https://doi.org/10.2174/1570162x16666180412165004
Publikováno v:
Journal of biomolecular structuredynamics. 38(4)
The X-ray crystal structures of HDAC8 complexed with largazole thiol (LAR, PubChem CID: 56663191) and its synthetic variants (Ligand ID in PDB, PubChem CID: L6G, 91667418; L7G, 91667421; L8G, 91667...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7246cbab6c649e5daf10e007ddbfa942
https://pubmed.ncbi.nlm.nih.gov/30909817
https://pubmed.ncbi.nlm.nih.gov/30909817
Autor:
Pravesh Verma, Saroj Verma, Kumkum Srivastava, P. M. Chauhan, Yenamandra S. Prabhakar, Shreekant Deshpande, Pooja Agarwal, Jitendra Kumar Saxena, Shashi Pandey
Publikováno v:
RSC Advances. 6:25584-25593
New N-(7-chloroquinolinyl-4-aminoalkyl)arylsulfonamides were synthesized and tested in vitro against P. falciparum 3D7 and K1 strains and hemozoin formation. Compounds 16 and 17 showed promising antimalarial activity (IC50 3D7: 0.05 and 0.01 μM; K1:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42dcabc37ca80f9d7c2f72645c09a202
https://doi.org/10.1039/c6ra00846a
https://doi.org/10.1039/c6ra00846a
Publikováno v:
Journal of Chemical Information and Modeling. 55:1708-1719
A strategy is described to identify new antimalarial agents to overcome the drug resistance and/or failure issues through in silico screening of multiple biological targets. As a part of this, three enzymes namely CTPS, CK, and GST were selected, fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e02ae031bce04f1bb06f18ea3baea8
https://doi.org/10.1021/acs.jcim.5b00392
https://doi.org/10.1021/acs.jcim.5b00392