Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Yen-Yu Ian Shih"'
Autor:
Yuhui Li, Sung-Ho Lee, Chunxiu Yu, Li-Ming Hsu, Tzu-Wen W. Wang, Khoa Do, Hyeon-Joong Kim, Yen-Yu Ian Shih, Warren M. Grill
Publikováno v:
Brain Stimulation, Vol 17, Iss 4, Pp 947-957 (2024)
While deep brain stimulation (DBS) is widely employed for managing motor symptoms in Parkinson's disease (PD), its exact circuit mechanisms remain controversial. To identify the neural targets affected by therapeutic DBS in PD, we analyzed DBS-evoked
Externí odkaz:
https://doaj.org/article/9acafa1d71b34e02b7d157815f6947a4
Autor:
Domenic H. Cerri, Daniel L. Albaugh, Lindsay R. Walton, Brittany Katz, Tzu-Wen Wang, Tzu-Hao Harry Chao, Weiting Zhang, Randal J. Nonneman, Jing Jiang, Sung-Ho Lee, Amit Etkin, Catherine N. Hall, Garret D. Stuber, Yen-Yu Ian Shih
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract The striatum, known as the input nucleus of the basal ganglia, is extensively studied for its diverse behavioral roles. However, the relationship between its neuronal and vascular activity, vital for interpreting functional magnetic resonanc
Externí odkaz:
https://doaj.org/article/7f2843290a2d4421b7c9e76dab4e7dfd
Autor:
Yuhling Wang, Shaoyu Yen, Yen-Yu Ian Shih, Chien-Wen Lai, Yu-Lin Chen, Li-Tzong Chen, Hsi Chen, Lun-De Liao
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110033- (2024)
Summary: Ischemic stroke can cause depolarized brain waves, termed peri-infarct depolarization (PID). Here, we evaluated whether topiramate, a neuroprotective drug used to treat epilepsy and alleviate migraine, has the potential to reduce PID. We emp
Externí odkaz:
https://doaj.org/article/0e60c7a8c28b4bc292323ff95a6f0ea3
Autor:
Connor M Wander, Ya-Dong Li, Hechen Bao, Brent Asrican, Yan-Jia Luo, Heather A Sullivan, Tzu-Hao Harry Chao, Wei-Ting Zhang, Samantha L Chéry, Dalton S Tart, Ze-Ka Chen, Yen-Yu Ian Shih, Ian R Wickersham, Todd J Cohen, Juan Song
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Alzheimer’s disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD therapeutics. So far, most treatments for AD that have the potential to improve memory target
Externí odkaz:
https://doaj.org/article/b86bc6cf52144cdf81b7f50dbae489f8
Autor:
Qinghui Wang, Zhengzheng Ruan, Lu Jing, Ziyang Guo, Xiaomeng Zhang, Jianing Liu, Lu Tian, Wei Sun, Sheng Song, Jau-Shyong Hong, Yen-Yu Ian Shih, Liyan Hou, Qingshan Wang
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 266, Iss , Pp 115550- (2023)
Microglia-mediated chronic neuroinflammation has been associated with cognitive decline induced by rotenone, a well-known neurotoxic pesticide used in agriculture. However, the mechanisms remain unclear. This work aimed to elucidate the role of compl
Externí odkaz:
https://doaj.org/article/e4cf199f47564cf592eea8a94822c71c
Autor:
Sung-Ho Lee, Tatiana A. Shnitko, Li-Ming Hsu, Margaret A. Broadwater, Mabelle Sardinas, Tzu-Wen Winnie Wang, Donita L. Robinson, Ryan P. Vetreno, Fulton T. Crews, Yen-Yu Ian Shih
Publikováno v:
Addiction Neuroscience, Vol 7, Iss , Pp 100105- (2023)
Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While evidence suggests that adolescent alcohol use affects frontal brain regions that are important for cognitive control over behavior, little is known about ho
Externí odkaz:
https://doaj.org/article/cbfbbe1f250041839ea2cf20a97650c7
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The salience network has been hypothesised to modulate default mode network activity during stimulus-driven cognition. Here, the authors show that in rats, stimulation of the anterior insular cortex, a key node of the salience network, suppresses the
Externí odkaz:
https://doaj.org/article/a506a7adcbc2496ca0f0736ca23b29d3
Autor:
Sheng Song, Dezhen Tu, Chengbo Meng, Jie Liu, Belinda Wilson, Qingshan Wang, Yen-Yu Ian Shih, Hui-Ming Gao, Jau-Shyong Hong
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Clinical and pathological evidence revealed that α-synuclein (α-syn) pathology seen in PD patients starts in the gut and spreads via anatomically connected structures from the gut to the brain. Our previous study demonstrated that depletion of cent
Externí odkaz:
https://doaj.org/article/de050ff19a674fdcbf95fce7b617833d
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101497- (2022)
Summary: Coupling of hemodynamic responses to neuronal activity is the foundation of several functional neuroimaging techniques. Here, we provide three fiber-photometry approaches to simultaneously measure neuronal and vascular signals in the rodent
Externí odkaz:
https://doaj.org/article/91b272521ca64fb98fde5ea6c26901f1
Autor:
Lindsay R Walton, Matthew Verber, Sung-Ho Lee, Tzu-Hao Harry Chao, R. Mark Wightman, Yen-Yu Ian Shih
Publikováno v:
NeuroImage, Vol 244, Iss , Pp 118634- (2021)
The vascular contributions of neurotransmitters to the hemodynamic response are gaining more attention in neuroimaging studies, as many neurotransmitters are vasomodulatory. To date, well-established electrochemical techniques that detect neurotransm
Externí odkaz:
https://doaj.org/article/08b7aaa958344eaaafd987f6a8bc134b