Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Yen-Hui Chan"'
Autor:
Cheng-Yu Tsai, Ying-Chang Lu, Yen-Hui Chan, Navaneethan Radhakrishnan, Yuan-Yu Chang, Shu-Wha Lin, Tien-Chen Liu, Chuan-Jen Hsu, Pei-Lung Chen, Lee-Wei Yang, Chen-Chi Wu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5698-5711 (2023)
Variants in the gap junction beta-2 (GJB2) gene are the most common cause of hereditary hearing impairment. However, how GJB2 variants lead to local physicochemical and structural changes in the hexameric ion channels of connexin 26 (Cx26), resulting
Externí odkaz:
https://doaj.org/article/4cc6f64e81f44b9c8a1e0e677fb5c287
Autor:
Yen-Hui Chan, Cheng-Yu Tsai, Chang-Han Ho, Ying-Chang Lu, Pei-Hsuan Lin, Ta-Ching Chen, You-Tzung Chen, Cheng-Yen Huang, Tien-Chen Liu, Chuan-Jen Hsu, Chen-Chi Wu
Publikováno v:
Stem Cell Research, Vol 69, Iss , Pp 103068- (2023)
Pathogenic variants of the WFS1 gene can cause recessive-inherited Wolfram syndrome or dominant-inherited Wolfram-like syndrome with optic atrophy and hearing impairment. Using the Sendai virus delivery system, we generated induced pluripotent stem c
Externí odkaz:
https://doaj.org/article/49e3de1a76214919a0162b874dcd28f8
Autor:
Chin-Ju Hu, Ying-Chang Lu, Cheng-Yu Tsai, Yen-Hui Chan, Pei-Hsuan Lin, Yi-Shan Lee, I.-Shing Yu, Shu-Wha Lin, Tien-Chen Liu, Chuan-Jen Hsu, Ting-Hua Yang, Yen-Fu Cheng, Chen-Chi Wu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Recessive variants of the SLC26A4 gene are an important cause of hereditary hearing impairment. Several transgenic mice with different Slc26a4 variants have been generated. However, none have recapitulated the auditory phenotypes in humans.
Externí odkaz:
https://doaj.org/article/39c68a982910479db6b294bf68ba68ea
Autor:
Yen-Hui Chan, Chang-Han Ho, Cheng-Yu Tsai, Ying-Chang Lu, Pei-Hsuan Lin, Ta-Ching Chen, You-Tzung Chen, Cheng-Yen Huang, Tien-Chen Liu, Chuan-Jen Hsu, Chen-Chi Wu
Publikováno v:
Stem Cell Research, Vol 64, Iss , Pp 102903- (2022)
Pathogenic variants of OPA1 have been associated with autosomal dominant optic atrophy (DOA), leading to optic, auditory, and other sensorineural neuropathies and myopathies. Using the Sendai virus delivery system, we generated induced pluripotent st
Externí odkaz:
https://doaj.org/article/44d5b4e1264b482692fd96e5abebf0b1
Autor:
Yen-Hui Chan, Yen-Fu Cheng, You-Tzung Chen, Cheng-Yen Huang, Chin-Hsien Lin, Chin-Ju Hu, Ying-Chang Lu, Chen-Chi Wu, Chuan-Jen Hsu
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 51-55 (2018)
Recessive mutations in the GJB2 gene are the most common genetic cause of hearing loss in humans. By using the Sendai-virus delivery system, we generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells of a female p
Externí odkaz:
https://doaj.org/article/368e9d8d3b314b279a6e044737d791c6
Autor:
Chun-Ying Huang, Yi-Hsiu Tsai, Yi-Ching Tsai, Ying-Chang Lu, Yen-Hui Chan, Chuan-Jen Hsu, Shih-Hwa Chiou, Chen-Chi Wu, Yen-Fu Cheng
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Gap junction protein beta 2 gene (GJB2) mutations are the most frequent cause of hereditary hearing impairment. The recessive c.235delC mutation in the GJB2 gene is the most common mutation causing severe to profound sensorineural hearing loss in the
Externí odkaz:
https://doaj.org/article/5bb9b7b1f6de4f40b06a6ddd88995115
Autor:
Yen-Fu Cheng, Yen-Hui Chan, Chin-Ju Hu, Ying-Chang Lu, Tsubasa Saeki, Makoto Hosoya, Chika Saegusa, Masato Fujioka, Hideyuki Okano, Shih-Ming Weng, Chuan-Jen Hsu, Kuo-Hsuan Chang, Chen-Chi Wu
Publikováno v:
Stem Cell Research, Vol 40, Iss , Pp - (2019)
SLC26A4 is the second most frequent gene implicated in congenital hearing loss after GJB2 mutations. Here, we report the generation of induced pluripotent stem cells (iPSCs), from a patient who was carrying a homozygous c.919-2A>G variant in the SLC2
Externí odkaz:
https://doaj.org/article/24aa29bed2464850a58dac84e29e8071
Autor:
Chin-Ju Hu, Ying-Chang Lu, Ting-Hua Yang, Yen-Hui Chan, Cheng-Yu Tsai, I-Shing Yu, Shu-Wha Lin, Tien-Chen Liu, Yen-Fu Cheng, Chen-Chi Wu, Chuan-Jen Hsu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2789 (2021)
Recessive variants of the SLC26A4 gene are globally a common cause of hearing impairment. In the past, cell lines and transgenic mice were widely used to investigate the pathogenicity associated with SLC26A4 variants. However, discrepancies in pathog
Externí odkaz:
https://doaj.org/article/c4126fff23244dd5a97c662cc3fa9642
Autor:
Jargalkhuu Erdenechuluun, Yin-Hung Lin, Khongorzul Ganbat, Delgermaa Bataakhuu, Zaya Makhbal, Cheng-Yu Tsai, Yi-Hsin Lin, Yen-Hui Chan, Chuan-Jen Hsu, Wei-Chung Hsu, Pei-Lung Chen, Chen-Chi Wu
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209797 (2018)
Genetic factors are an important cause of idiopathic sensorineural hearing impairment (SNHI). From the epidemiological perspective, mutations of three deafness genes: GJB2, SLC26A4, and MT-RNR1, are much more prevalent than those of other genes world
Externí odkaz:
https://doaj.org/article/b84639b2dbde45d19d1438f0019e82f8
Autor:
Yen-Hui Chan, 詹彥輝
99
Salivary glands locate at the start of digestive system and are responsible for the secretion of saliva, which has many functions in maintaining homeostasis of the oral cavity. However, radiotherapy and autoimmune diseases may cause dysfuncti
Salivary glands locate at the start of digestive system and are responsible for the secretion of saliva, which has many functions in maintaining homeostasis of the oral cavity. However, radiotherapy and autoimmune diseases may cause dysfuncti
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/13729710921765391839
