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Distinct metabolic requirements regulate B cell activation and germinal center responses.

Autor: Sharma R; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Smolkin RM; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA., Chowdhury P; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Fernandez KC; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Kim Y; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Cols M; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Alread W; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yen WF; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hu W; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wang ZM; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA., Violante S; Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chaligné R; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Li MO; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Cross JR; Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chaudhuri J; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chaudhuj@mskcc.org.; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA. chaudhuj@mskcc.org.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA. chaudhuj@mskcc.org.

Publikováno v: Nature immunology [Nat Immunol] 2023 Aug; Vol. 24 (8), pp. 1358-1369. Date of Electronic Publication: 2023 Jun 26.

A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.

Autor: Yewdell WT; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Kim Y; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Chowdhury P; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Lau CM; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Smolkin RM; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA., Belcheva KT; Biochemistry, Cellular and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Fernandez KC; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Cols M; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Yen WF; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Vaidyanathan B; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Angeletti D; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., McDermott AB; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Yewdell JW; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Sun JC; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA., Chaudhuri J; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA. Electronic address: chaudhuj@mskcc.org.

Publikováno v: Immunity [Immunity] 2020 Nov 17; Vol. 53 (5), pp. 952-970.e11. Date of Electronic Publication: 2020 Oct 23.

Distinct Requirements of CHD4 during B Cell Development and Antibody Response.

Autor: Yen WF; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Biochemistry, Cellular and Molecular Biology Program, Weill Graduate School of Medical Sciences, New York, NY, USA., Sharma R; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cols M; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lau CM; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chaudhry A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chowdhury P; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Yewdell WT; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Vaidyanathan B; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Sun A; Department of Pathology, New York University School of Medicine, New York, NY, USA., Coffre M; Department of Pathology, New York University School of Medicine, New York, NY, USA., Pucella JN; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA., Chen CC; Biochemistry, Cellular and Molecular Biology Program, Weill Graduate School of Medical Sciences, New York, NY, USA; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jasin M; Biochemistry, Cellular and Molecular Biology Program, Weill Graduate School of Medical Sciences, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sun JC; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA., Rudensky AY; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Koralov SB; Department of Pathology, New York University School of Medicine, New York, NY, USA., Chaudhuri J; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA. Electronic address: chaudhuj@mskcc.org.

Publikováno v: Cell reports [Cell Rep] 2019 Apr 30; Vol. 27 (5), pp. 1472-1486.e5.

BRCT-domain protein BRIT1 influences class switch recombination.

Autor: Yen WF; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Biochemistry, Cellular and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065., Chaudhry A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Vaidyanathan B; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065., Yewdell WT; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Pucella JN; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Gerstner Sloan Kettering Graduate School, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Sharma R; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Liang Y; The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030., Li K; The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030., Rudensky AY; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Gerstner Sloan Kettering Graduate School, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Chaudhuri J; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; chaudhuj@mskcc.org.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065.; Gerstner Sloan Kettering Graduate School, Memorial Sloan Kettering Cancer Center, New York, NY 10065.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Aug 01; Vol. 114 (31), pp. 8354-8359. Date of Electronic Publication: 2017 Jul 19.