Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Yen K. Lieu"'
1
SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes
Autor: Yen K. Lieu, Zhaoqi Liu, Abdullah M. Ali, Xin Wei, Alex Penson, Jian Zhang, Xiuli An, Raul Rabadan, Azra Raza, James L. Manley, Siddhartha Mukherjee
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance Myelodysplastic syndromes (MDS) are the most commonly diagnosed malignancy of the elderly in the United States, but what causes severe anemia in MDS has been unknown. Our findings provide a detailed mechanism underlying the origins of se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e027f8350de53337048f875b952ff033
http://europepmc.org/articles/PMC8740767
Zobrazit plný text záznamu
2
SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes
Autor: Siddhartha Mukherjee, Yen K. Lieu, James L. Manley, Jing Zhang, Xiuli An, Zhouzerui Liu, Wei X, Abdullah Mahmood Ali, Azra Raza, Raul Rabadan, Alex Penson
SF3B1 is the most frequently mutated RNA splicing factor in multiple neoplasms, including ~25% of myelodysplastic syndromes (MDS) patients. Mortality in MDS frequently results from severe anemia, but the underlying mechanism is largely unknown. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1dddf9cbcbdd2a2c9684ccba7a52889
https://doi.org/10.1101/2020.06.24.169052
Zobrazit plný text záznamu
4
B- myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development
Autor: Edward Y. Chen, Avi Ma'ayan, Yen K. Lieu, Hans-Willem Snoeck, E. Premkumar Reddy, Premila John, M. V. Ramana Reddy, Qiaonan Duan, Stacey J. Baker
Publikováno v: Proceedings of the National Academy of Sciences. 111:3122-3127
The B-myb (MYBL2) gene is a member of the MYB family of transcription factors and is involved in cell cycle regulation, DNA replication, and maintenance of genomic integrity. However, its function during adult development and hematopoiesis is unknown
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7ded726e50b9aca20f4e796995e141
https://doi.org/10.1073/pnas.1315464111
Zobrazit plný text záznamu
5
Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1
Autor: Raul Rabadan, Azra Raza, Jian Zhang, Yen K. Lieu, Zhaoqi Liu, Abdullah Mahmood Ali, Siddhartha Mukherjee, James L. Manley, Jianchao Gao
Publikováno v: Mol Cell
SF3B1, which encodes an essential spliceosomal protein, is frequently mutated in myelodysplastic syndromes (MDS) and many cancers. However, the defect of mutant SF3B1 is unknown. Here, we analyzed RNA-sequencing data from MDS patients and confirmed t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e5121051cf6f841b89be99e17843bf
https://doi.org/10.1016/j.molcel.2019.07.017
Zobrazit plný text záznamu
6
Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout mice
Autor: Yen K. Lieu, E. Premkumar Reddy
Publikováno v: Cell Cycle. 11:3504-3512
The differentiation of myeloid progenitors to mature, terminally differentiated cells is a highly regulated process. Here, we showed that conditional disruption of the c-myb proto-oncogene in adult mice resulted in dramatic reductions in CMP, GMP and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5844d03ec209cb1ee2d55837a61db4b6
https://doi.org/10.4161/cc.21802
Zobrazit plný text záznamu
7
Conditional c- myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation
Autor: Yen K. Lieu, E. Premkumar Reddy
Publikováno v: Proceedings of the National Academy of Sciences. 106:21689-21694
Hematopoietic stem cells (HSCs) have a unique capacity to undergo self-renewal and multi-lineage differentiation to provide a lifetime supply of mature blood cells. By using conditional knockout technology, we disrupted the c- myb proto-oncogene spec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afffaa1f5b2e981e51e103ab2523cbf
https://doi.org/10.1073/pnas.0907623106
Zobrazit plný text záznamu
8
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities
Autor: James L. Manley, Raul Rabadan, Azra Raza, Alex Penson, Abdullah Mahmood Ali, Kathryn S. Reggio, Siddhartha Mukherjee, Jian Zhang, Yen K. Lieu
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 112(34)
Serine/arginine-rich splicing factor 2 (SRSF2) is an RNA-binding protein that plays important roles in splicing of mRNA precursors. SRSF2 mutations are frequently found in patients with myelodysplastic syndromes and certain leukemias, but how these m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4f8feba7b4005247482b431d9e77eb
https://pubmed.ncbi.nlm.nih.gov/26261309
Zobrazit plný text záznamu
10
Requirement ofc-mybin T cell development and in mature T cell function
Autor: Atul Kumar, E. Premkumar Reddy, Thomas J. Rogers, Yen K. Lieu, Anthony G. Pajerowski
Publikováno v: Proceedings of the National Academy of Sciences. 101:14853-14858
Previous reports have suggested that the protooncogenec-mybparticipates in T cell development in the thymus and mature T cell proliferation. We have generated two T cell-specificc-mybknockout mouse models, myb/LckCre and myb/CD4Cre. We have demonstra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ce0d8f075df66029ceccb2799f4688
https://doi.org/10.1073/pnas.0405338101
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje