Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Yen Chin, Koay"'
Autor:
Shashwati Dutta, Desmond Li, Andy Wang, Mark Ishak, Kristina Cook, Melissa Farnham, Hasthi Dissanayake, Peter Cistulli, Imre Hunyor, Renping Liu, Ian Wilcox, Yen Chin Koay, Jean Yang, Sean Lal, John F. O'Sullivan
Publikováno v:
ESC Heart Failure, Vol 8, Iss 6, Pp 5392-5402 (2021)
Abstract Aims Sleep apnoea and congestive heart failure (CHF) commonly co‐exist, but their interaction is unclear. Metabolomics may clarify their interaction and relationships to outcome. Methods and results We assayed 372 circulating metabolites a
Externí odkaz:
https://doaj.org/article/77d97b4e03494399852c0fe724ada71a
Autor:
Benita C. Y. Tse, Angela L. Ferguson, Yen Chin Koay, Georges E. Grau, Anthony S. Don, Scott N. Byrne
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
The ability of ultraviolet radiation to suppress the immune system is thought to be central to both its beneficial (protection from autoimmunity) and detrimental (carcinogenic) effects. Previous work revealed a key role for lipids particularly platel
Externí odkaz:
https://doaj.org/article/439c0caa92d54bf7aa7933e19b9447de
Autor:
Taiyun Kim, Owen Tang, Stephen T. Vernon, Katharine A. Kott, Yen Chin Koay, John Park, David E. James, Stuart M. Grieve, Terence P. Speed, Pengyi Yang, Gemma A. Figtree, John F. O’Sullivan, Jean Yee Hwa Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Mass spectrometry-based metabolomics is a powerful method for profiling large clinical cohorts but batch variations can obscure biologically meaningful differences. Here, the authors develop a computational workflow that removes unwanted data variati
Externí odkaz:
https://doaj.org/article/b9f05e117dcb4f2a9c9c505e343dfa63
Autor:
Jason Behary, Nadia Amorim, Xiao-Tao Jiang, Anita Raposo, Lan Gong, Emily McGovern, Ragy Ibrahim, Francis Chu, Carlie Stephens, Hazem Jebeili, Vincenzo Fragomeli, Yen Chin Koay, Miriam Jackson, John O’Sullivan, Martin Weltman, Geoffrey McCaughan, Emad El-Omar, Amany Zekry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Disease-specific gut microbiome signatures have been previously defined for patients with liver cirrhosis or hepatocellular carcinoma (HCC). Here the authors examine the composition of the gut microbiota in cirrhotic patients with non-alcoholic fatty
Externí odkaz:
https://doaj.org/article/b2728d3b48ed45bd99530aeb278cdc20
Autor:
Michel Bernier, Dylan Harney, Yen Chin Koay, Antonio Diaz, Abhishek Singh, Devin Wahl, Tamara Pulpitel, Ahmed Ali, Vince Guiterrez, Sarah J. Mitchell, Eun-Young Kim, John Mach, Nathan L. Price, Miguel A. Aon, David G. LeCouteur, Victoria C. Cogger, Carlos Fernandez-Hernando, John O’Sullivan, Mark Larance, Ana Maria Cuervo, Rafael de Cabo
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-11 (2020)
Abstract There is an unmet need and urgency to find safe and effective anti-obesity interventions. Our recent study in mice fed on obesogenic diet found that treatment with the alcohol aversive drug disulfiram reduced feeding efficiency and led to a
Externí odkaz:
https://doaj.org/article/6764f6e5a0bd403f9dbc67a86fdcd3e6
Autor:
Mengbo Li, Benjamin L. Parker, Evangeline Pearson, Benjamin Hunter, Jacob Cao, Yen Chin Koay, Oneka Guneratne, David E. James, Jean Yang, Sean Lal, John F. O’Sullivan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Study of human heart failure is limited by access to human tissue. Here, the authors apply multi-omic screening in human ischaemic and dilated myocardial tissue and matched controls to determine molecular changes common and unique to each aetiology a
Externí odkaz:
https://doaj.org/article/dc50dd89da9c42378ed20e5b3c379c66
Autor:
Yen Chin Koay, Adelle C. F. Coster, Daniel L. Chen, Brad Milner, Amani Batarseh, John F. O’Sullivan, Jerry R. Greenfield, Dorit Samocha-Bonet
Publikováno v:
Metabolites, Vol 12, Iss 12, p 1272 (2022)
The liver, skeletal muscle, and adipose tissue are major insulin target tissues and key players in glucose homeostasis. We and others have described diverse insulin resistance (IR) phenotypes in people at risk of developing type 2 diabetes. It is pos
Externí odkaz:
https://doaj.org/article/9ebf7af27b5044149bc324274ca0c6fc
Autor:
Siân P. Cartland, Scott W. Genner, Gonzalo J. Martínez, Stacy Robertson, Maaike Kockx, Ruby CY. Lin, John F. O'Sullivan, Yen Chin Koay, Pradeep Manuneedhi Cholan, Melkam A. Kebede, Andrew J. Murphy, Seth Masters, Martin R. Bennett, Wendy Jessup, Leonard Kritharides, Carolyn Geczy, Sanjay Patel, Mary M. Kavurma
Publikováno v:
iScience, Vol 12, Iss , Pp 41-52 (2019)
Summary: Circulating tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) levels are reduced in patients with cardiovascular disease, and TRAIL gene deletion in mice exacerbates atherosclerosis and inflammation. How TRAIL protects ag
Externí odkaz:
https://doaj.org/article/c7ca2592d76c4f63b979d841c5be347e
Autor:
Alison W. S. Luk, Lachlan Mitchell, Yen Chin Koay, John F. O’Sullivan, Helen O’Connor, Daniel A. Hackett, Andrew Holmes
Publikováno v:
Metabolites, Vol 12, Iss 10, p 911 (2022)
Diet, exercise and the gut microbiome are all factors recognised to be significant contributors to cardiometabolic health. However, diet and exercise interventions to modify the gut microbiota to improve health are limited by poor understanding of th
Externí odkaz:
https://doaj.org/article/f3e9b79ed2384808919211f973bdfb20
Autor:
Luke Hatchwell, Dylan J. Harney, Michelle Cielesh, Kieren Young, Yen Chin Koay, John F. O’Sullivan, Mark Larance
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3566-3582.e4 (2020)
Summary: Every-other-day fasting (EODF) is an effective intervention for the treatment of metabolic disease, including improvements in liver health. But how the liver proteome is reprogrammed by EODF is currently unknown. Here, we use EODF in mice an
Externí odkaz:
https://doaj.org/article/237e432c2e57473e973503e386901c72