Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

Autor: Brian D. Reed, Michael J. Meyer, Valentin Abramzon, Omer Ad, Pat Adcock, Faisal R. Ahmad, Gün Alppay, James A. Ball, James Beach, Dominique Belhachemi, Anthony Bellofiore, Michael Bellos, Juan Felipe Beltrán, Andrew Betts, Mohammad Wadud Bhuiya, Kristin Blacklock, Robert Boer, David Boisvert, Norman D. Brault, Aaron Buxbaum, Steve Caprio, Changhoon Choi, Thomas D. Christian, Robert Clancy, Joseph Clark, Thomas Connolly, Kathren Fink Croce, Richard Cullen, Mel Davey, Jack Davidson, Mohamed M. Elshenawy, Michael Ferrigno, Daniel Frier, Saketh Gudipati, Stephanie Hamill, Zhaoyu He, Sharath Hosali, Haidong Huang, Le Huang, Ali Kabiri, Gennadiy Kriger, Brittany Lathrop, An Li, Peter Lim, Stephen Liu, Feixiang Luo, Caixia Lv, Xiaoxiao Ma, Evan McCormack, Michele Millham, Roger Nani, Manjula Pandey, John Parillo, Gayatri Patel, Douglas H. Pike, Kyle Preston, Adeline Pichard-Kostuch, Kyle Rearick, Todd Rearick, Marco Ribezzi-Crivellari, Gerard Schmid, Jonathan Schultz, Xinghua Shi, Badri Singh, Nikita Srivastava, Shannon F. Stewman, TR Thurston, T. R. Thurston, Philip Trioli, Jennifer Tullman, Xin Wang, Yen-Chih Wang, Eric A. G. Webster, Zhizhuo Zhang, Jorge Zuniga, Smita S. Patel, Andrew D. Griffiths, Antoine M. van Oijen, Michael McKenna, Matthew D. Dyer, Jonathan M. Rothberg

Publikováno v: Science. 378:186-192

Studies of the proteome would benefit greatly from methods to directly sequence and digitally quantify proteins and detect posttranslational modifications with single-molecule sensitivity. Here, we demonstrate single-molecule protein sequencing using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d3367086ac787e208c4c79a68cbb83f
https://doi.org/10.1126/science.abo7651

Translation of peptidoglycan metabolites into immunotherapeutics

Autor: Matthew E Griffin, Charles W Hespen, Yen‐Chih Wang, Howard C Hang

Publikováno v: Clinical & Translational Immunology, Vol 8, Iss 12, Pp n/a-n/a (2019)

Abstract The discovery of defined peptidoglycan metabolites that activate host immunity and their specific receptors has revealed fundamental insights into host–microbe recognition and afforded new opportunities for therapeutic development against

Externí odkaz: https://doaj.org/article/2da86f47ee2d4a0885b24615df594db8

Chemical Reporters for Exploring Microbiology and Microbiota Mechanisms

Autor: Zhenrun J. Zhang, Howard C. Hang, Yen Chih Wang, Xinglin Yang

Publikováno v: Chembiochem

The advances made in bioorthogonal chemistry and the development of chemical reporters have afforded new strategies to explore the targets and functions of specific metabolites in biology. These metabolite chemical reporters have been applied to dive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e95e40f0eb46cd69983451e056dbb6
https://doi.org/10.1002/cbic.201900535

Author response: Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

Autor: Jin Young Kang, Charles W Hespen, Howard C. Hang, Juliel Espinosa, Virginia A. Pedicord, Byungchul Kim, Yen Chih Wang, Deena A. Oren, Jeanne Salje, Kavita J. Rangan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8ec1e3e6b474274de9753869d86d755
https://doi.org/10.7554/elife.45343.039

Cost-based scheduling method using object-oriented approach

Autor: Heap-Yih Chong, Su-Ling Fan, Yen-Chih Wang, Tsung-Wei Hung

Publikováno v: Automation in Construction. 65:65-77

Cost and schedule performances share common variables for effective project control. However, the real-world implementations of breakdown structures for cost and schedule are at different levels of detail, which makes the integration of cost and sche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a8faa3cacba37a65ab32a53d3abffa4
https://doi.org/10.1016/j.autcon.2016.01.007