Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection.

Autor: Kofoed EM; Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA., Aliagas I; Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA., Crawford T; Department of Medicinal Chemistry, Genentech Inc., South San Francisco, California, USA., Mao J; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Harris SF; Department of Structural Biology, Genentech Inc., South San Francisco, California, USA., Xu M; Department of Translational Immunology, Genentech Inc., South San Francisco, California, USA., Wang S; Department of Medicinal Chemistry, Genentech Inc., South San Francisco, California, USA., Wu P; Department of Structural Biology, Genentech Inc., South San Francisco, California, USA., Ma F; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Clark K; Department of Biochemistry and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., Sims J; Department of Developmental Sciences Safety Assessment, Genentech Inc., South San Francisco, California, USA., Xu Y; Department of Biochemistry and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., Peng Y; Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA., Skippington E; Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA., Yang Y; Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA., Reeder J; Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA., Ubhayakar S; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Baumgardner M; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Yan Z; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Chen J; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Park S; Department of Translational Immunology, Genentech Inc., South San Francisco, California, USA., Zhang H; Department of Translational Immunology, Genentech Inc., South San Francisco, California, USA., Yen C-W; Department of Small Molecule Pharmaceutical Science, Genentech Inc., South San Francisco, California, USA., Lorenzo M; Department of Protein Chemistry, Genentech Inc., South San Francisco, California, USA., Skelton N; Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA., Liang X; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Chen L; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Hoag B; Department of Biochemistry and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., Li CS; WuXi AppTec Co., Ltd., Shanghai, China., Liu Z; WuXi AppTec Co., Ltd., Shanghai, China., Wai J; WuXi AppTec Co., Ltd., Shanghai, China., Liu X; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Liang J; Department of Medicinal Chemistry, Genentech Inc., South San Francisco, California, USA., Tan MW; Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA.

Publikováno v: MBio [mBio] 2024 Oct 16; Vol. 15 (10), pp. e0089724. Date of Electronic Publication: 2024 Aug 29.

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