Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Yemin, Lan"'
Autor:
Hannah M. Kolev, Avital Swisa, Elisabetta Manduchi, Yemin Lan, Rachel R. Stine, Giuseppe Testa, Klaus H. Kaestner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 4, Pp 821-839 (2023)
Background & Aims: Although trimethylation of histone H3 lysine 27 (H3K27me3) by polycomb repressive complex 2 is required for intestinal function, the role of the antagonistic process—H3K27me3 demethylation—in the intestine remains unknown. The
Externí odkaz:
https://doaj.org/article/a95e54038c994905928595d51e834d0f
Autor:
Jennifer M Luppino, Andrew Field, Son C Nguyen, Daniel S Park, Parisha P Shah, Richard J Abdill, Yemin Lan, Rebecca Yunker, Rajan Jain, Karen Adelman, Eric F Joyce
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010528 (2022)
The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. NIPBL and WAPL are two opposing regulators of cohesin activity; depletion of either is associated with changes in both chromatin folding and transcriptio
Externí odkaz:
https://doaj.org/article/6f10829c89194c2f98ca805aea9865a4
Autor:
Suhee Chang, Diana Fulmer, Stella K Hur, Joanne L Thorvaldsen, Li Li, Yemin Lan, Eric A Rhon-Calderon, Nicolae Adrian Leu, Xiaowen Chen, Jonathan A Epstein, Marisa S Bartolomei
Publikováno v:
eLife, Vol 11 (2022)
Dysregulation of the imprinted H19/IGF2 locus can lead to Silver-Russell syndrome (SRS) in humans. However, the mechanism of how abnormal H19/IGF2 expression contributes to various SRS phenotypes remains unclear, largely due to incomplete understandi
Externí odkaz:
https://doaj.org/article/6e1ce1ff28534687a37e77cf4367e911
Autor:
Haoyue Zhang, Jessica Lam, Di Zhang, Yemin Lan, Marit W. Vermunt, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Higher-order chromatin structure is temporarily disrupted during mitosis. Here the authors show that loss of the architectural factor CTCF results in failure to form structural loops and leads to inappropriate cis-regulatory contacts and alterations
Externí odkaz:
https://doaj.org/article/08ba3d74d9e640238388f116decac99f
Autor:
Lisa A. Vrooman, Eric A. Rhon-Calderon, Kashviya V. Suri, Asha K. Dahiya, Yemin Lan, Richard M. Schultz, Marisa S. Bartolomei
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Assisted Reproductive Technologies (ART) employ gamete/embryo handling and culture in vitro to produce offspring. ART pregnancies have an increased risk of low birth weight, abnormal placentation, pregnancy complications, and imprinting disorders. Em
Externí odkaz:
https://doaj.org/article/405f514faa63424991e2178a37e8e6d0
Autor:
Rodrigo A. Gier, Krista A. Budinich, Niklaus H. Evitt, Zhendong Cao, Elizabeth S. Freilich, Qingzhou Chen, Jun Qi, Yemin Lan, Rahul M. Kohli, Junwei Shi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Reliable, multiplexed gene editing to uncover synergies between targets remains challenging. Here, the authors engineer AsCas12a and the crRNA to improve double knockout for synthetic sick/lethal interaction genetic screening.
Externí odkaz:
https://doaj.org/article/200dde47acd44d708c32a6bcf129cbd0
Autor:
Jennifer R. Aleman, Terra M. Kuhn, Pau Pascual-Garcia, Janko Gospocic, Yemin Lan, Roberto Bonasio, Shawn C. Little, Maya Capelson
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109236- (2021)
Summary: Dosage compensation in Drosophila melanogaster involves a 2-fold transcriptional upregulation of the male X chromosome, which relies on the X-chromosome-binding males-specific lethal (MSL) complex. However, how such 2-fold precision is accom
Externí odkaz:
https://doaj.org/article/618af2db683e46e195e66554c9359e33
Autor:
Jing Luan, Guanjue Xiang, Pablo Aurelio Gómez-García, Jacob M. Tome, Zhe Zhang, Marit W. Vermunt, Haoyue Zhang, Anran Huang, Cheryl A. Keller, Belinda M. Giardine, Yu Zhang, Yemin Lan, John T. Lis, Melike Lakadamyali, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108783- (2021)
Summary: CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor implicated in a wide range of functions, including genome organization, transcription activation, and elongation. To explore the basis for CTCF functional diversity,
Externí odkaz:
https://doaj.org/article/043972196e1e41779878b3c99b1de8c7
Autor:
John Kee, Samuel Thudium, David M. Renner, Karl Glastad, Katherine Palozola, Zhen Zhang, Yize Li, Yemin Lan, Joseph Cesare, Andrey Poleshko, Anna A. Kiseleva, Rachel Truitt, Fabian L. Cardenas-Diaz, Xianwen Zhang, Xuping Xie, Darrell N. Kotton, Konstantinos D. Alysandratos, Jonathan A. Epstein, Pei-Yong Shi, Wenli Yang, Edward Morrisey, Benjamin A. Garcia, Shelley L. Berger, Susan R. Weiss, Erica Korb
Publikováno v:
Nature. 610:381-388
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID-19), in part because of its ability to effectively suppress host cell responses
Autor:
Yi Hu, Jon G. Sanders, Piotr Łukasik, Catherine L. D’Amelio, John S. Millar, David R. Vann, Yemin Lan, Justin A. Newton, Mark Schotanus, Daniel J. C. Kronauer, Naomi E. Pierce, Corrie S. Moreau, John T. Wertz, Philipp Engel, Jacob A. Russell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Gut bacteria are prevalent across insects including ants, but their precise roles are often unclear. Here, Hu et al. show that microbes aid ants by recycling nitrogen into bio-available amino acids. This function is conserved across the turtle ants,
Externí odkaz:
https://doaj.org/article/d9b391e19cbc4dceb4b083246b646635