Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yemeserach, Bishaw"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 122-132 (2020)
Micro-dystrophin (μDys) gene therapeutics can improve striated muscle structure and function in different animal models of Duchenne muscular dystrophy. Most studies, however, used young mdx mice that lack a pronounced dystrophic phenotype, short tre
Externí odkaz:
https://doaj.org/article/40f52319db4042c0855c6b3404dcfa19
Autor:
John K. Mich, Lucas T. Graybuck, Erik E. Hess, Joseph T. Mahoney, Yoshiko Kojima, Yi Ding, Saroja Somasundaram, Jeremy A. Miller, Brian E. Kalmbach, Cristina Radaelli, Bryan B. Gore, Natalie Weed, Victoria Omstead, Yemeserach Bishaw, Nadiya V. Shapovalova, Refugio A. Martinez, Olivia Fong, Shenqin Yao, Marty Mortrud, Peter Chong, Luke Loftus, Darren Bertagnolli, Jeff Goldy, Tamara Casper, Nick Dee, Ximena Opitz-Araya, Ali Cetin, Kimberly A. Smith, Ryder P. Gwinn, Charles Cobbs, Andrew L. Ko, Jeffrey G. Ojemann, C. Dirk Keene, Daniel L. Silbergeld, Susan M. Sunkin, Viviana Gradinaru, Gregory D. Horwitz, Hongkui Zeng, Bosiljka Tasic, Ed S. Lein, Jonathan T. Ting, Boaz P. Levi
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108754- (2021)
Summary: Viral genetic tools that target specific brain cell types could transform basic neuroscience and targeted gene therapy. Here, we use comparative open chromatin analysis to identify thousands of human-neocortical-subclass-specific putative en
Externí odkaz:
https://doaj.org/article/f3fbdff3e4964a89bce059657aed05d2
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Keinan B Agonias, Marissa Watanabe, Danuta Szczesna-Cordary, Anna M Huckabee, Katarzyna Kazmierczak, Yemeserach Bishaw
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H881-H890
Mavacamten is a pharmaceutical that binds to myosin, and it is under investigation as a therapy for some forms of heart disease. We show that mavacamten reduces isometric tension and Ca2+ sensitivity of contraction in skinned myocardial strips from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a40277588c30da2939131bbd1bfbd1
https://doi.org/10.1152/ajpheart.00345.2020
https://doi.org/10.1152/ajpheart.00345.2020
Autor:
Yemeserach Bishaw, Maya Guglin Guglin, Kenneth S. Campbell, Marissa Watanabe, Bertrand C.W. Tanner, Peter O. Awinda
Publikováno v:
British Journal of Pharmacology. 177:5609-5621
Background and purpose Heart failure can reflect impaired contractile function at the myofilament level. In healthy hearts, myofilaments become more sensitive to Ca2+ as cells are stretched. This represents a fundamental property of the myocardium th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac58bbaa4e722425cf02fc247d5e9a9b
https://doi.org/10.1111/bph.15271
https://doi.org/10.1111/bph.15271
Autor:
Joseph T. Mahoney, Kimberly A. Smith, Refugio A. Martinez, Victoria Omstead, Ed S. Lein, Natalie Weed, Lucas T. Graybuck, Darren Bertagnolli, Luke Loftus, Jeffrey G. Ojemann, Boaz P. Levi, Jonathan T. Ting, John K. Mich, Yoshiko Kojima, Gregory D. Horwitz, Tamara Casper, Jeff Goldy, Andrew L. Ko, Yi Ding, Bryan B. Gore, Cristina Radaelli, C. Dirk Keene, Olivia Fong, Viviana Gradinaru, Marty Mortrud, Ximena Opitz-Araya, Yemeserach Bishaw, Nick Dee, Nadiya V. Shapovalova, Brian E. Kalmbach, Jeremy A. Miller, Hongkui Zeng, Charles Cobbs, Bosiljka Tasic, Daniel L. Silbergeld, Shenqin Yao, Ali Cetin, Ryder P. Gwinn, Hess Erik, Saroja Somasundaram, Peter Chong, Susan M. Sunkin
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108754-(2021)
Cell reports
Cell reports
SUMMARY Viral genetic tools that target specific brain cell types could transform basic neuroscience and targeted gene therapy. Here, we use comparative open chromatin analysis to identify thousands of human-neocortical-sub-class-specific putative en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837142427b14bce46b297cb2811b6e81
https://resolver.caltech.edu/CaltechAUTHORS:20200421-093728277
https://resolver.caltech.edu/CaltechAUTHORS:20200421-093728277
Autor:
Peter O, Awinda, Marissa, Watanabe, Yemeserach, Bishaw, Anna M, Huckabee, Keinan B, Agonias, Katarzyna, Kazmierczak, Danuta, Szczesna-Cordary, Bertrand C W, Tanner
Publikováno v:
Am J Physiol Heart Circ Physiol
Morbidity and mortality associated with heart disease is a growing threat to the global population, and novel therapies are needed. Mavacamten (formerly called MYK-461) is a small molecule that binds to cardiac myosin and inhibits myosin ATPase. Mava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9556d1c34ff2f57d61885ae211b80d11
https://pubmed.ncbi.nlm.nih.gov/33337957
https://pubmed.ncbi.nlm.nih.gov/33337957
Autor:
Bertrand C.W. Tanner, Yemeserach Bishaw, Peter O. Awinda, Maya Guglin Guglin, Marissa Watanabe, Kenneth S. Campbell
Background and Purpose: Heart failure can reflect impaired contractile function at the myofilament level. In healthy hearts, myofilaments become more sensitive to Ca2+ as cells are stretched. This represents a fundamental property of myocardium that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801e5f625cd417489be1c83ba39f6eff
https://doi.org/10.22541/au.158878883.32913834
https://doi.org/10.22541/au.158878883.32913834
Autor:
Peter O, Awinda, Yemeserach, Bishaw, Marissa, Watanabe, Maya A, Guglin, Kenneth S, Campbell, Bertrand C W, Tanner
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Heart failure can reflect impaired contractile function at the myofilament level. In healthy hearts, myofilaments become more sensitive to Ca(2+) as cells are stretched. This represents a fundamental property of the myocardium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a89779c0ed48fcd7529d9b1bea3f0770
https://pubmed.ncbi.nlm.nih.gov/32960449
https://pubmed.ncbi.nlm.nih.gov/32960449
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Yemeserach Bishaw, Marissa Watanabe, Katherine L. Thompson, Mindy S. Thompson, Emma J. Birks, Kenneth S. Campbell
Publikováno v:
Biophysical Journal. 121:107a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42657d41ff20930ab3aad2fb14aae108
https://doi.org/10.1016/j.bpj.2021.11.2182
https://doi.org/10.1016/j.bpj.2021.11.2182
Publikováno v:
Human Gene Therapy. 29:390-399
Striated muscle wasting occurs with a variety of disease indications, contributing to mortality and compromising life quality. Recent studies indicate that the recombinant adeno-associated virus (serotype 6) Smad7 gene therapeutic, AVGN7, enhances sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff730ca0499142f1eb74128a6c696582
https://doi.org/10.1089/hum.2017.158
https://doi.org/10.1089/hum.2017.158