Characterization of Live-Attenuated Powassan Virus Vaccine Candidates Identifies an Efficacious Prime-Boost Strategy for Mitigating Powassan Virus Disease in a Murine Model

Autor: Andrew M. Cheung, Elaine Z. Yip, Alison W. Ashbrook, Niluka Goonawardane, Corrine Quirk, Charles M. Rice, Margaret R. MacDonald, Hans-Heinrich Hoffmann

Publikováno v: Vaccines, Vol 11, Iss 3, p 612 (2023)

Powassan virus (POWV) is an emerging tick-borne virus and cause of lethal encephalitis in humans. The lack of treatment or prevention strategies for POWV disease underscores the need for an effective POWV vaccine. Here, we took two independent approa

Externí odkaz: https://doaj.org/article/c9877e3cacd14c7f98a32cc80b007701

Retention of a recombinant GFP protein expressed by the yellow fever 17D virus in the E/NS1 intergenic region in the endoplasmic reticulum

Autor: Gisela Freitas Trindade, Marlon Gilsepp Veloso de Santana, Juliana Ribeiro dos Santos, Ricardo Galler, Myrna Cristina Bonaldo

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 107, Iss 2, Pp 262-272 (2012)

The flaviviral envelope proteins, E protein and precursor membrane protein, are mainly associated with the endoplasmic reticulum (ER) through two transmembrane (TM) domains that are exposed to the luminal face of this compartment. Their retention is

Externí odkaz: https://doaj.org/article/8c1ec7ca901945cc99965bb5712a5333

Retention of a recombinant GFP protein expressed by the yellow fever 17D virus in the E/NS1 intergenic region in the endoplasmic reticulum

Autor: Juliana Ribeiro dos Santos, Gisela Freitas Trindade, Ricardo Galler, Marlon G. Veloso de Santana, Myrna C. Bonaldo

Publikováno v: Memórias do Instituto Oswaldo Cruz, Volume: 107, Issue: 2, Pages: 262-272, Published: MAR 2012
Memórias do Instituto Oswaldo Cruz., Vol 107, Iss 2, Pp 262-272 (2012)

The flaviviral envelope proteins, E protein and precursor membrane protein, are mainly associated with the endoplasmic reticulum (ER) through two transmembrane (TM) domains that are exposed to the luminal face of this compartment. Their retention is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0f1208ce73446b97a82521fc221dde
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000200017&lng=en&tlng=en

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