Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca2+ release

Autor: Thomas E. Jensen, Lykke Sylow, Adam J. Rose, Agnete B. Madsen, Yeliz Angin, Stine J. Maarbjerg, Erik A. Richter

Publikováno v: Molecular Metabolism, Vol 3, Iss 7, Pp 742-753 (2014)

Understanding how muscle contraction orchestrates insulin-independent muscle glucose transport may enable development of hyperglycemia-treating drugs. The prevailing concept implicates Ca2+ as a key feed forward regulator of glucose transport with se

Externí odkaz: https://doaj.org/article/054097813ac940bc997a3e8a0a423b12

Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca2+ release

Autor: Agnete B. Madsen, Yeliz Angin, Stine Maarbjerg, Erik A. Richter, Adam J. Rose, Lykke Sylow, Thomas E. Jensen

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 3, Iss 7, Pp 742-753 (2014)

Understanding how muscle contraction orchestrates insulin-independent muscle glucose transport may enable development of hyperglycemia-treating drugs. The prevailing concept implicates Ca(2+) as a key feed forward regulator of glucose transport with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2f58cf605c39eebf44033004dc8997

Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake

Autor: Jan F. C. Glatz, Reyhan Nergiz-Unal, Johan W. M. Heemskerk, Arend Bonen, Yeliz Angin, Nicole Hoebers, Joost J. F. P. Luiken, Robert W. Schwenk, Marijke J.E. Kuijpers, Dietbert Neumann, Marc A. M. J. van Zandvoort, Will A. Coumans

Publikováno v: American Journal of Physiology : Endocrinology and Metabolism, 307(2), E225-E236. American Physiological Society

Activation of AMP-activated protein kinase (AMPK) in cardiomyocytes induces translocation of glucose transporter GLUT4 and long-chain fatty acid (LCFA) transporter CD36 from endosomal stores to the sarcolemma to enhance glucose and LCFA uptake, respe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf55f6f687247d2e4bcc237021a5e2ac
https://doi.org/10.1152/ajpendo.00655.2013

Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK

Autor: Yeliz, Angin, Christophe, Beauloye, Sandrine, Horman, Luc, Bertrand

Publikováno v: Experientia supplementum (2012). 107

This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis. AMPK acts as whole-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::520b646fc19856a2db361f59f06d466c
https://pubmed.ncbi.nlm.nih.gov/27812975

CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes

Autor: Will A. Coumans, Wino Wijnen, Marc A. M. J. van Zandvoort, Nicole Hoebers, Michaela Diamant, Peter J. Simons, Sabrina Greulich, Jan F. C. Glatz, Kim Douma, Laura K.M. Steinbusch, Yeliz Angin, Joost J. F. P. Luiken, D. Margriet Ouwens

Publikováno v: Biochemical Journal, 448, 43-53. Portland Press Ltd.
Angin, Y, Steinbusch, L K M, Simons, P J, Greulich, S, Hoebers, N T H, Douma, K, van Zandvoort, M A M J, Coumans, W A, Wijnen, W, Diamant, M, Ouwens, D M, Glatz, J F C & Luiken, J J F P 2012, ' CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes ', Biochemical Journal, vol. 448, pp. 43-53 . https://doi.org/10.1042/BJ20120060

An increased cardiac fatty acid supply and increased sarcolemmal presence of the long-chain fatty acid transporter CD36 are associated with and contribute to impaired cardiac insulin sensitivity and function. In the present study we aimed at preventi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9743a7e58a41741246d35ed23f26afb
https://doi.org/10.1042/bj20120060