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Current understanding of metal-dependent amyloid-β aggregation and toxicity

Autor: Yelim Yi, Mi Hee Lim

Publikováno v: RSC Chemical Biology. 4:121-131

This review describes the effects of metal ions on the aggregation and toxicity profiles of Aβ.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c9817b17e9df9f128745915718d701e
https://doi.org/10.1039/d2cb00208f

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Impact of sphingosine and acetylsphingosines on the aggregation and toxicity of metal-free and metal-treated amyloid-β†

Autor: Geewoo Nam, Hyuck Jin Lee, Yuxi Lin, Yelim Yi, Young-Ho Lee, Nahye Park, Young S. Park, Jiyeon Han, Mi Hee Lim

Publikováno v: Chemical Science

Pathophysiological shifts in the cerebral levels of sphingolipids in Alzheimer's disease (AD) patients suggest a link between sphingolipid metabolism and the disease pathology. Sphingosine (SP), a structural backbone of sphingolipids, is an amphiphil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2d83025d37451abb5f99443ec3a0b2
http://europepmc.org/articles/PMC8179336

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Drug repurposing: small molecules against Cu(II)-amyloid-β and free radicals

Autor: Yelim Yi, Jong-Min Suh, Mi Hee Lim, Geewoo Nam

Publikováno v: Journal of inorganic biochemistry. 224

Alzheimer's disease (AD) presents a complex pathology entangling numerous pathological factors, including amyloid-β (Aβ), metal ions, and reactive oxygen species (ROS). Increasing evidence reveals pathological connections among these distinct compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf7d8fd5b8fbb46b5ae288486ceb5cd
https://pubmed.ncbi.nlm.nih.gov/34482237

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Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)–amyloid-β

Autor: Jiyeon Han, Min Hee Park, Hee Kyung Jin, Nahye Park, Mi Hee Lim, Eunju Nam, Yelim Yi, Jae-sung Bae

Publikováno v: Chemical Communications. 55:5847-5850

We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(ii)-bound amyloid-β [Zn(ii)-Aβ], two pathological targets found in the brain affected by Alzheimer's diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffa1fdc539cdcd91a4a011aa9512add
https://doi.org/10.1039/c9cc01005j

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Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease

Autor: Yelim Yi, Yuxi Lin, Young-Ho Lee, Hyuck Jin Lee, Mi Hee Lim, Geewoo Nam, Yonghwan Ji, Mingeun Kim, Juhye Kang

Publikováno v: ACS chemical neuroscience. 10(8)

We report orobol as a multifunctional isoflavone with the ability to (i) modulate the aggregation pathways of both metal-free and metal-bound amyloid-β, (ii) interact with metal ions, (iii) scavenge free radicals, and (iv) inhibit the activity of ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b663ca061688cbaf2bcb094d361dc1c6
https://pubmed.ncbi.nlm.nih.gov/32285655

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