Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Yelena V. Parfyonova"'
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Mhd Amin Arssan, Aleksei A. Sleptcov, Maria S. Nazarenko, Aleksei A. Zarubin, Nina V. Zheltysheva, Vlada A. Shevchenko, Narek A. Tmoyan, Shoraan B. Saaya, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 689 (2024)
Defects in the low-density lipoprotein receptor (LDLR) are associated with familial hypercholesterolemia (FH), manifested by atherosclerosis and cardiovascular disease. LDLR deficiency in hepatocytes leads to elevated blood cholesterol levels, which
Externí odkaz:
https://doaj.org/article/1a367c718be94a42babd8f91bc18a80c
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Ekaterina S. Zubkova, Aleksei A. Sleptcov, Maria S. Nazarenko, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102702- (2022)
The development of cellular models for familial hypercholesterolemia (FH) is an important direction for creating new approaches to atherosclerosis treatment. Pathogenic mutations in the LDLR gene are the main FH source. We generated an iPSC line from
Externí odkaz:
https://doaj.org/article/9ce40e3c957e4fa490098316d4c73f75
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Alexander P. Kalinin, Aleksei A. Sleptcov, Maria S. Nazarenko, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102703- (2022)
Familial hypercholesterolemia (FH) is an autosomal dominant disorder increasing premature cardiovascular diseases risk due to atherosclerosis. Pathogenic mutations in the LDLR gene cause most FH cases. Available treatments are effective not for all L
Externí odkaz:
https://doaj.org/article/e73fe039606f4f28b043708a40e0e084
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Ekaterina S. Zubkova, Aleksei A. Sleptcov, Maria S. Nazarenko, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 59, Iss , Pp 102653- (2022)
Familial hypercholesterolemia (FH) is a monogenic disease, leading to atherosclerosis due to a high level of low-density lipoprotein cholesterol. Most cases of the disease are based on pathological variants in the LDLR gene. Hepatocyte-like and endot
Externí odkaz:
https://doaj.org/article/f5e3fb638e9f4e6db50a85dd319f5d83
Autor:
Maria S. Nazarenko, Aleksei A. Sleptcov, Aleksei A. Zarubin, Ramil R. Salakhov, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Ekaterina S. Zubkova, Nina V. Zheltysheva, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian, Irina S. Zakharova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4471 (2023)
The LDLR locus has clinical significance for lipid metabolism, Mendelian familial hypercholesterolemia (FH), and common lipid metabolism-related diseases (coronary artery disease and Alzheimer’s disease), but its intronic and structural variants ar
Externí odkaz:
https://doaj.org/article/76a44709a6c6408fb24208c4eaacb4dc
Autor:
Konstantin V. Dergilev, Zoya I. Tsokolaeva, Irina B. Beloglazova, Anastasia V. Komova, Sofia V. Pavlova, Dmitry O. Traktuev, Yelena V. Parfyonova
Publikováno v:
Общая реаниматология, Vol 15, Iss 6, Pp 38-49 (2019)
Aim: to evaluate the impact of tissue-engineered structures (TES) transplantation based on mesenchymal stromal cell (MSC) sheets in myocardial infarction on the activation of the epicardial cell pool and vascularization of the damaged zone.Materials
Externí odkaz:
https://doaj.org/article/920e3e55264f4793a442a9ca5c6b0811
Autor:
Ekaterina S. Zubkova, Irina B. Beloglazova, Elizaveta I. Ratner, Daniyar T. Dyikanov, Konstantin V. Dergilev, Mikhail Yu. Menshikov, Yelena V. Parfyonova
Publikováno v:
Biology Open, Vol 10, Iss 9 (2021)
Ex vivo, gene therapy is a powerful approach holding great promises for the treatment of both genetic and acquired diseases. Adeno-associated virus (AAV) vectors are a safe and efficient delivery system for modification of mesenchymal stem cells (MSC
Externí odkaz:
https://doaj.org/article/abd2febe167b47d491a73cfaa1c924e5
Autor:
Iurii S. Stafeev I, Maria A. Boldyreva, Svetlana S. Michurina, Margarita Yu. Agareva, Arina V. Radnaeva, Mikhail Yu. Menshikov, Yu-Chen Hu, Pavel I. Makarevich, Yelena V. Parfyonova
Publikováno v:
Cells, Vol 11, Iss 23, p 3824 (2022)
Background: Combined non-viral gene therapy (GT) of ischemia and cardiovascular disease is a promising tool for potential clinical translation. In previous studies our group has developed combined gene therapy by vascular endothelial growth factor 16
Externí odkaz:
https://doaj.org/article/58b2e8ff11524bf08842ac3272e091eb
Autor:
Konstantin V. Dergilev, Evgeny K. Shevchenko, Zoya I. Tsokolaeva, Irina B. Beloglazova, Ekaterina S. Zubkova, Maria A. Boldyreva, Mikhail Yu. Menshikov, Elizaveta I. Ratner, Dmitry Penkov, Yelena V. Parfyonova
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9603 (2020)
Cell therapy of the post-infarcted myocardium is still far from clinical use. Poor survival of transplanted cells, insufficient regeneration, and replacement of the damaged tissue limit the potential of currently available cell-based techniques. In t
Externí odkaz:
https://doaj.org/article/570895ba0f05446c9e71fd1a2de842dd
Autor:
Maria A. Boldyreva, Evgeny K. Shevchenko, Yuliya D. Molokotina, Pavel I. Makarevich, Irina B. Beloglazova, Ekaterina S. Zubkova, Konstantin V. Dergilev, Zoya I. Tsokolaeva, Dmitry Penkov, Mu-Nung Hsu, Yu-Chen Hu, Yelena V. Parfyonova
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3088 (2019)
Cell therapy remains a promising approach for the treatment of cardiovascular diseases. In this regard, the contemporary trend is the development of methods to overcome low cell viability and enhance their regenerative potential. In the present study
Externí odkaz:
https://doaj.org/article/bd9d21aa6d374d14a5b6574b5aca026e