Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yelena V. Kovtun"'
Autor:
Wayne C. Widdison, Ravi V.J. Chari, John M. Lambert, Hans K. Erickson, Qifeng Qiu, Rui Wu, Paulin Salomon, Rabih Gabriel, Anna Skaletskaya, Juliet A. Costoplus, Karen Veale, Leanne Lanieri, Jennifer A. Coccia, Gregory E. Jones, Ling Dong, Nathan Fishkin, E. Erica Hong, Katharine C. Lai, Yelena V. Kovtun, Jose Ponte, Yulius Y. Setiady, Rajeeva Singh
Supplementary Methods (S1-S3). Supplementary Method S1: Synthesis of di-, tri-, tetra-glycyl, and valine-citrulline-glycine peptide linkers and catabolites. Supplementary Method S2: Test of in vitro cytotoxicity, cell-cycle inhibition, and bystander
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b6d4b4f9c44ca6353724746b9d8c98
https://doi.org/10.1158/1535-7163.22503028.v1
https://doi.org/10.1158/1535-7163.22503028.v1
Autor:
Wayne C. Widdison, Ravi V.J. Chari, John M. Lambert, Hans K. Erickson, Qifeng Qiu, Rui Wu, Paulin Salomon, Rabih Gabriel, Anna Skaletskaya, Juliet A. Costoplus, Karen Veale, Leanne Lanieri, Jennifer A. Coccia, Gregory E. Jones, Ling Dong, Nathan Fishkin, E. Erica Hong, Katharine C. Lai, Yelena V. Kovtun, Jose Ponte, Yulius Y. Setiady, Rajeeva Singh
Supplementary Table S1: Amounts of catabolites generated upon treatment of cancer cells with CX and SMCC ADCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1bbdc7f0c64a9492add2e343489150
https://doi.org/10.1158/1535-7163.22503025.v1
https://doi.org/10.1158/1535-7163.22503025.v1
Autor:
Wayne C. Widdison, Ravi V.J. Chari, John M. Lambert, Hans K. Erickson, Qifeng Qiu, Rui Wu, Paulin Salomon, Rabih Gabriel, Anna Skaletskaya, Juliet A. Costoplus, Karen Veale, Leanne Lanieri, Jennifer A. Coccia, Gregory E. Jones, Ling Dong, Nathan Fishkin, E. Erica Hong, Katharine C. Lai, Yelena V. Kovtun, Jose Ponte, Yulius Y. Setiady, Rajeeva Singh
Supplementary Figures (S1-S4). Supplementary Figure S1: In vitro cytotoxic activities of tetraglycyl (Gly4), triglycyl (Gly3), diglycyl (Gly2), and valine-citrulline-glycine (VCG)-linked anti-EGFR ADCs and a triglycyl-linked non-binding antibody ADC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dfc500f111def02ff705de4c140fe0
https://doi.org/10.1158/1535-7163.22503031.v1
https://doi.org/10.1158/1535-7163.22503031.v1
Autor:
Ravi V.J. Chari, Victor S. Goldmacher, Rajeeva Singh, Robert J. Lutz, Jan Pinkas, Holly Johnson, Brenda Kellogg, Wayne C. Widdison, Katharine C. Lai, Olga Ab, Sharon Wilhelm, Xiuxia Sun, Hans K. Erickson, Erin K. Maloney, Heather Doherty, Gregory E. Jones, Michele F. Mayo, Charlene A. Audette, Yelena V. Kovtun
Supplementary Tables 1-2, Figures 1-4 from Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa317c3d2229511f14aced6f2534a5d
https://doi.org/10.1158/0008-5472.22385855
https://doi.org/10.1158/0008-5472.22385855
Autor:
Walter A. Blättler, Victor S. Goldmacher, Robert J. Lutz, Karen Hoffman, Lisa M. Garrett, Yelena V. Kovtun, Wayne C. Widdison, Peter U. Park, Hans K. Erickson
Supplementary Figures S1-S5 from Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563a7d6e238f33647ce10e7a69755818
https://doi.org/10.1158/0008-5472.22365749.v1
https://doi.org/10.1158/0008-5472.22365749.v1
Autor:
Walter A. Blättler, Victor S. Goldmacher, Robert J. Lutz, Karen Hoffman, Lisa M. Garrett, Yelena V. Kovtun, Wayne C. Widdison, Peter U. Park, Hans K. Erickson
Supplementary Figure Legends S1-S5 from Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148651bf8922c4cba523d2e4240ad41b
https://doi.org/10.1158/0008-5472.22365755
https://doi.org/10.1158/0008-5472.22365755
Autor:
Walter A. Blättler, Victor S. Goldmacher, Robert J. Lutz, Karen Hoffman, Lisa M. Garrett, Yelena V. Kovtun, Wayne C. Widdison, Peter U. Park, Hans K. Erickson
Antibody-drug conjugates are targeted anticancer agents consisting of a cytotoxic drug covalently linked to a monoclonal antibody for tumor antigen–specific activity. Once bound to the target cell-surface antigen, the conjugate must be processed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b699e419a52b321ba84a41935977d8b
https://doi.org/10.1158/0008-5472.c.6494843.v1
https://doi.org/10.1158/0008-5472.c.6494843.v1
Autor:
Victor S Goldmacher, Charlene A Audette, Yinghua Guan, Eriene-Heidi Sidhom, Jagesh V Shah, Kathleen R Whiteman, Yelena V Kovtun
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117523 (2015)
The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. To identify the mechanisms of this intracellular a
Externí odkaz:
https://doaj.org/article/e72da5b89d77491ea5ee1090969d22e4
Publikováno v:
Plant Molecular Biology. 23:435-438
A middle repetitive sequence NPR18 was isolated from Nicotiana plumbaginifolia nuclear genome [8]. Sequences homologous to the repeat are dispersed through genomes of several Nicotiana species. Computer-assisted data analysis of NPR18 primary sequenc