Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Yelena V. Grinkova"'
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 853 (2022)
Human cytochrome P450 CYP3A4 is involved in the processing of more than 35% of current pharmaceuticals and therefore is responsible for multiple drug-drug interactions (DDI). In order to develop a method for the detection and prediction of the possib
Externí odkaz:
https://doaj.org/article/92e5ee7a233646d9a727dfab2e651c8d
Publikováno v:
Metabolites, Vol 9, Iss 8, p 158 (2019)
Enniatins (ENNs) are fungal secondary metabolites that frequently occur in grain in temperate climates. Their toxic potency is connected to their ionophoric character and lipophilicity. The biotransformation of ENNs predominantly takes place via cyto
Externí odkaz:
https://doaj.org/article/e87005015b614209842a6d1a5a3e5d18
Autor:
Ilia G. Denisov, Stephen G. Sligar, Michael C. Gregory, Yilin Liu, Yelena V. Grinkova, James R. Kincaid
Publikováno v:
Biochemistry
Steroid metabolism in humans originates from cholesterol and involves several enzyme reactions including dehydrogenation, hydroxylation, and carbon–carbon bond cleavage that occur at regio- and stereo-specific points in the four-membered ring struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547aff033426072361c5f67408b05fc8
https://doi.org/10.1021/acs.biochem.1c00282
https://doi.org/10.1021/acs.biochem.1c00282
Publikováno v:
Biochemistry
We developed an efficient and sensitive probe for drug–drug interactions mediated by human CYP3A4 by using midazolam (MDZ) as a probe substrate. Using global analysis of four parameters over several experimental data sets, we demonstrate that the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b142bed1837d74f3c50c9c8445b8313a
https://doi.org/10.1021/acs.biochem.1c00161
https://doi.org/10.1021/acs.biochem.1c00161
Publikováno v:
Chemistry
Human cytochrome P450 CYP17A1 first catalyzes hydroxylation at the C17 position of either pregnenolone (PREG) or progesterone (PROG), and a subsequent C(17)–C(20) bond scission to produce dehydroepiandrosterone (DHEA) or androstenedione (AD). In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfdf31d6d0dc3faed356d25c2afbe6b
https://doi.org/10.1002/chem.202003181
https://doi.org/10.1002/chem.202003181
Publikováno v:
Anal Biochem
We describe the construction, expression and purification of three new membrane scaffold proteins (MSP) for use in assembling Nanodiscs. These new MSPs have a variety of luminescent properties for use in combination with several analytical methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32197ef81e0ccbc663f30cd413169622
https://pubmed.ncbi.nlm.nih.gov/32750355
https://pubmed.ncbi.nlm.nih.gov/32750355
Publikováno v:
Biochemistry. 57:805-816
Heterotropic interactions between atorvastatin (ARVS) and dronedarone (DND) have been deciphered using global analysis of the results of binding and turnover experiments for pure drugs and their mixtures. The in vivo presence of atorvastatin lactone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83526ad762f95008d55c0e954356a586
https://doi.org/10.1021/acs.biochem.7b01012
https://doi.org/10.1021/acs.biochem.7b01012
Publikováno v:
Metabolites
Volume 9
Issue 8
Metabolites, Vol 9, Iss 8, p 158 (2019)
Volume 9
Issue 8
Metabolites, Vol 9, Iss 8, p 158 (2019)
Enniatins (ENNs) are fungal secondary metabolites that frequently occur in grain in temperate climates. Their toxic potency is connected to their ionophoric character and lipophilicity. The biotransformation of ENNs predominantly takes place via cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e247156f0130ea05fa99b779419df8ad
Autor:
Emad Tajkhorshid, Yelena V. Grinkova, Prithviraj Nandigrami, Mrinal Shekhar, Ilia G. Denisov, Stephen G. Sligar
Publikováno v:
Biochemistry
The role of Phe213 in the allosteric mechanism of human cytochrome P450 CYP3A4 was studied using a combination of progesterone (PGS) and carbamazepine (CBZ) as probe substrates. We expressed, purified, and incorporated into POPC Nanodiscs three mutan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7e9f6774e9204ca5c49b0f33ddb302
https://pubmed.ncbi.nlm.nih.gov/31181900
https://pubmed.ncbi.nlm.nih.gov/31181900
Publikováno v:
Biochemistry. 54:2227-2239
Using Nanodiscs, we quantitate the heterotropic interaction between two different drugs mediated by monomeric CYP3A4 incorporated into a native-like membrane environment. The mechanism of this interaction is deciphered by global analysis of multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbb47f4791dfcf37e6b23f3ba1195ca
https://doi.org/10.1021/acs.biochem.5b00079
https://doi.org/10.1021/acs.biochem.5b00079