Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yelena Sarkisova"'
Autor:
Zhihong Huang, Jennifer Shaffer, Badry Bursulaya, Anna Galkin, Rie Kikkawa, Yelena Sarkisova, Su Hua, John Tellew, Yang Yang, Paul Vincent Rucker, Robert Epple, Jiqing Jiang, Nanxin Li, Chianelli Donatella, Jason Roland, Lintong Li, Sergio Briones, Casey J. N. Mathison, Valentina Molteni, Jacqueline Kinyamu-Akunda, Mu-Yun Gao, John Nelson, Christian C. Lee, Yun Feng Xie, Shailaja Kasibhatla, Chun Li
Publikováno v:
ACS Med Chem Lett
[Image: see text] The selective inhibition of RET kinase as a treatment for relevant cancer types including lung adenocarcinoma has garnered considerable interest in recent years and prompted a variety of efforts toward the discovery of small-molecul
Autor:
Badry Bursulaya, Nanxin Li, Yang Yang, Chianelli Donatella, John Nelson, Casey J. N. Mathison, Valentina Molteni, Sergio Briones, Chun Li, Shailaja Kasibhatla, Christian C. Lee, Jason Roland, Zhihong Huang, Jiqing Jiang, Anna Galkin, John Tellew, Robert Epple, Jacqueline Kinyamu-Akunda, Yelena Sarkisova, Mu-Yun Gao, Rie Kikkawa, Lintong Li, Su Hua, Paul Vincent Rucker, Jennifer Shaffer, Yun Feng Xie
Publikováno v:
ACS Medicinal Chemistry Letters. 11:558-565
RET (REarranged during Transfection) kinase gain-of-function aberrancies have been identified as potential oncogenic drivers in lung adenocarcinoma, along with several other cancer types, prompting the discovery and assessment of selective inhibitors
Autor:
Young Kim, Tove Tuntland, H. Martin Seidel, Thomas H. Marsilje, Nanxin Li, Wei Pei, You-Qun He, Xiaoming Cui, Wendy Richmond, Markus Warmuth, Auzon Steffy, Alex Aycinena, Sungjoon Kim, W. Perry Gordon, Donald S. Karanewsky, AnneMarie Culazzo Pferdekamper, Jin Yunho, Jonathan Chang, Ruo Steensma, Jennifer L. Harris, Bo Liu, Sean B. Joseph, Yelena Sarkisova, Christian C. Lee, Todd Groessl, Bei Chen, Wenshuo Lu, Chopiuk Greg, Tao Jiang, Kevin Johnson, Tetsuo Uno, Pierre-Yves Michellys, Jiqing Jiang, Andrew Phimister, Allen G. Li, Nathanael S. Gray, Badry Bursulaya, Frank Sun, Yongqin Wan, Jie Li
Publikováno v:
Journal of Medicinal Chemistry. 56:5675-5690
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report, preliminary structure–activity relationships (SARs)
Autor:
Thomas H, Marsilje, Wei, Pei, Bei, Chen, Wenshuo, Lu, Tetsuo, Uno, Yunho, Jin, Tao, Jiang, Sungjoon, Kim, Nanxin, Li, Markus, Warmuth, Yelena, Sarkisova, Frank, Sun, Auzon, Steffy, AnneMarie C, Pferdekamper, Allen G, Li, Sean B, Joseph, Young, Kim, Bo, Liu, Tove, Tuntland, Xiaoming, Cui, Nathanael S, Gray, Ruo, Steensma, Yongqin, Wan, Jiqing, Jiang, Greg, Chopiuk, Jie, Li, W Perry, Gordon, Wendy, Richmond, Kevin, Johnson, Jonathan, Chang, Todd, Groessl, You-Qun, He, Andrew, Phimister, Alex, Aycinena, Christian C, Lee, Badry, Bursulaya, Donald S, Karanewsky, H Martin, Seidel, Jennifer L, Harris, Pierre-Yves, Michellys
Publikováno v:
Journal of medicinal chemistry. 56(14)
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report, preliminary structure-activity relationships (SARs) a
Autor:
Loren Jon, Yelena Sarkisova, Fangxian Sun, Yong Jia, Guoxun Liu, Donald S. Karanewsky, Min Lu, Nanxin Li, Shenlin Huang, Francisco Adrian, Andreas Kreusch, Yuan Mi, Zuosheng Liu, Tove Tuntland, H. Martin Seidel, Yi Fan, Valentina Molteni, Tami Hood, Pam Albaugh
Publikováno v:
ACS medicinal chemistry letters. 3(2)
Neurotrophins and their receptors (TRKs) play key roles in the development of the nervous system and the maintenance of the neural network. Accumulating evidence points to their role in malignant transformations, chemotaxis, metastasis, and survival
Autor:
Allen G. Li, Su Hua, Peter McNamara, Xiuying Sun, Jennifer L. Harris, Celin Tompkins, Pierre-Yves Michellys, Nanxin Li, Auzon Steffy, Yelena Sarkisova, Thomas H. Marsilje, Ralph Tiedt, Shailaja Kasibhatla, Frank Sun, Jie Li, AnneMarie Culazzo Pferdekamper, Sungjoon Kim
Publikováno v:
Molecular Cancer Therapeutics. 10:B232-B232
A c-MET/ALK kinase inhibitor crizotinib has demonstrated significant activity in lung cancer patients with EML4-ALK in clinical studies. However relapse (or acquired resistance) has also been reported. We have developed crizotinib resistant tumor mod