Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Yelena Mironchik"'
Autor:
Jiefu Jin, James D. Barnett, Yelena Mironchik, John Gross, Hisataka Kobayashi, Adam Levin, Zaver M. Bhujwalla
Publikováno v:
Translational Oncology, Vol 45, Iss , Pp 101966- (2024)
Epithelioid sarcoma (ES) is a rare soft tissue neoplasm with high recurrence rates. Wide surgical resection remains the only potential curative treatment. ES presents most commonly on the fingers, hands and forearm, making light-based cancer cell-tar
Externí odkaz:
https://doaj.org/article/145cfc641185488286f80010ce61b80c
Autor:
Jesus Pacheco-Torres, Raj Kumar Sharma, Yelena Mironchik, Flonne Wildes, W. Nathaniel Brennen, Dmitri Artemov, Balaji Krishnamachary, Zaver M. Bhujwalla
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Fibroblasts are versatile cells that play a major role in wound healing by synthesizing and remodeling the extracellular matrix (ECM). In cancers, fibroblasts play an expanded role in tumor progression and dissemination, immunosuppression, and metabo
Externí odkaz:
https://doaj.org/article/b82b6850e65b4f2a8e102224b072f600
Autor:
Eibhlin Goggins, Yelena Mironchik, Samata Kakkad, Desmond Jacob, Flonne Wildes, Zaver M. Bhujwalla, Balaji Krishnamachary
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
Vascular endothelial growth factor (VEGF) plays key roles in angiogenesis, vasculogenesis, and wound healing. In cancers, including triple negative breast cancer (TNBC), VEGF has been associated with increased invasion and metastasis, processes that
Externí odkaz:
https://doaj.org/article/7de7ef596dd74256b90ba25f74b60c12
Autor:
Noriko Mori, Jiefu Jin, Balaji Krishnamachary, Yelena Mironchik, Flonné Wildes, Farhad Vesuna, James D. Barnett, Zaver M. Bhujwalla
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Fibroblast activation protein-α (FAP-α) is a transmembrane serine protease that is attracting significant interest as it is expressed by a subgroup of cancer-associated fibroblasts that play a role in immune suppression and cancer metastasis. FAP-
Externí odkaz:
https://doaj.org/article/2926d382ab704ed4a2173398f419dc65
Autor:
Jesus Pacheco-Torres, Marie-France Penet, Yelena Mironchik, Balaji Krishnamachary, Zaver M. Bhujwalla
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Background Harnessing the power of the immune system by using immune checkpoint inhibitors has resulted in some of the most exciting advances in cancer treatment. The full potential of this approach has, however, not been fully realized for
Externí odkaz:
https://doaj.org/article/8db68ae8c2c048e9baa726a3d17de458
Autor:
Balaji Krishnamachary, Yelena Mironchik, Desmond Jacob, Eibhlin Goggins, Samata Kakkad, Francis Ofori, Louis Dore-Savard, Santosh Kumar Bharti, Flonne Wildes, Marie-France Penet, Margaret E Black, Zaver M Bhujwalla
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 679-688 (2020)
Hypoxia is frequently observed in human prostate cancer, and is associated with chemoresistance, radioresistance, metastasis, and castrate-resistance. Our purpose in these studies was to perform hypoxia theranostics by combining in vivo hypoxia imagi
Externí odkaz:
https://doaj.org/article/94007aec6209474f88e3fe69d26e9b91
Autor:
Jesus Pacheco-Torres, Marie-France Penet, Balaji Krishnamachary, Yelena Mironchik, Zhihang Chen, Zaver M. Bhujwalla
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
PurposeThe inhibition of immune checkpoints such as programmed cell death ligand-1 (PD-L1/CD274) with antibodies is providing novel opportunities to expose cancer cells to the immune system. Antibody based checkpoint blockade can, however, result in
Externí odkaz:
https://doaj.org/article/860445ef813442d6894c50ba732f14e3
Autor:
Shanshan Tan, Zhihang Chen, Yelena Mironchik, Noriko Mori, Marie-France Penet, Ge Si, Balaji Krishnamachary, Zaver M. Bhujwalla
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1260 (2022)
The availability of nanoparticles (NPs) to deliver small interfering RNA (siRNA) has significantly expanded the specificity and range of ‘druggable’ targets for precision medicine in cancer. This is especially important for cancers such as triple
Externí odkaz:
https://doaj.org/article/2267f31d38b94590a7896d820d1eb352
Autor:
Eibhlin Goggins, Samata Kakkad, Yelena Mironchik, Desmond Jacob, Flonne Wildes, Balaji Krishnamachary, Zaver M. Bhujwalla
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 2, Pp 131-139 (2018)
Hypoxia inducible factors (HIFs) are transcription factors that mediate the response of cells to hypoxia. HIFs have wide-ranging effects on metabolism, the tumor microenvironment (TME) and the extracellular matrix (ECM). Here we investigated the sile
Externí odkaz:
https://doaj.org/article/64c09dda13954d5c80e3c4a7941929f9
Autor:
Marie-France Penet, Balaji Krishnamachary, Flonné B. Wildes, Yelena Mironchik, Chien-Fu Hung, TC Wu, Zaver M. Bhujwalla
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Epithelial ovarian cancer is the leading cause of death from gynecologic malignancy among women in developed countries. Epithelial ovarian cancer has a poor prognosis, due to the aggressive characteristics of the disease combined with the lack of eff
Externí odkaz:
https://doaj.org/article/bba5e769157f462daa2310587ccc3d65