Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Yelena Kovtun"'
Autor:
Yelena Kovtun, Gregory E. Jones, Sharlene Adams, Lauren Harvey, Charlene A. Audette, Alan Wilhelm, Chen Bai, Lingyun Rui, Rassol Laleau, Fenghua Liu, Olga Ab, Yulius Setiady, Nicholas C. Yoder, Victor S. Goldmacher, Ravi V.J. Chari, Jan Pinkas, Thomas Chittenden
Publikováno v:
Blood Advances, Vol 2, Iss 8, Pp 848-858 (2018)
Abstract: The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppr
Externí odkaz:
https://doaj.org/article/221c467857af4029b2863119ee489741
Autor:
Evgeniya Angelova, Charlene Audette, Yelena Kovtun, Naval Daver, Sa A. Wang, Sherry Pierce, Sergej N. Konoplev, Haitham Khogeer, Jeffrey L. Jorgensen, Marina Konopleva, Patrick A. Zweidler-McKay, L. Jeffrey Medeiros, Hagop M. Kantarjian, Elias J. Jabbour, Joseph D. Khoury
Publikováno v:
Haematologica, Vol 104, Iss 4 (2019)
The potential of CD123-targeted therapies in acute lymphoblastic leukemia/lymphoma remains largely unexplored. We examined CD123 expression levels in a large cohort of patients with acute lymphoblastic leukemia/lymphoma and assessed the in vitro impa
Externí odkaz:
https://doaj.org/article/06f028d2f45b400fa072b97577ee8cd0
Publikováno v:
Tuning Journal for Higher Education, Vol 3, Iss 1, Pp 149-185 (2015)
The article is focused on the correlation of competencies, learning outcomes and the methods of their assessment in the course of current, interim (end-of-module) and final assessment. It provides a general idea of the background and difficulties ass
Externí odkaz:
https://doaj.org/article/4d8a3071d2124297a56015bded0b95e3
Autor:
Ravi V.J. Chari, Thomas A. Keating, Jan Pinkas, Olga Ab, Katharine C. Lai, Yelena Kovtun, Nicholas C. Yoder, Jose F. Ponte, Rajeeva Singh, Luke Harris, Dilrukshi Vitharana, Chen Bai, Katie E. Archer, Qifeng Qiu, Lauren Harvey, Erin K. Maloney, Surina Sikka, Leanne Lanieri, Emily E. Reid, Paulin Salomon, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Tumor-selective delivery of cytotoxic agents in the form of antibody–drug conjugates (ADCs) is now a clinically validated approach for cancer treatment. In an attempt to improve the clinical success rate of ADCs, emphasis has been recently placed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d1e99e32e1b6463933f4f9a2e6edc1f
https://doi.org/10.1158/1535-7163.c.6537900.v1
https://doi.org/10.1158/1535-7163.c.6537900.v1
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Comparative in vitro potency of IGNs with a diimine (1), monoimine (3), and diamine (2) towards hematologic and solid tumor cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060b3dbf22b8e72bcb6de9a2cf408c75
https://doi.org/10.1158/1535-7163.22508386
https://doi.org/10.1158/1535-7163.22508386
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Synthesis of IGNs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4d0a62fe9e14ab872c4a228aa07177
https://doi.org/10.1158/1535-7163.22508392.v1
https://doi.org/10.1158/1535-7163.22508392.v1
Autor:
Ravi V.J. Chari, Thomas A. Keating, Jan Pinkas, Olga Ab, Katharine C. Lai, Yelena Kovtun, Nicholas C. Yoder, Jose F. Ponte, Rajeeva Singh, Luke Harris, Dilrukshi Vitharana, Chen Bai, Katie E. Archer, Qifeng Qiu, Lauren Harvey, Erin K. Maloney, Surina Sikka, Leanne Lanieri, Emily E. Reid, Paulin Salomon, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Figure S1. Structural representations and scheme for preparation of IGN ADCs. Figure S2A. In vitro potency comparing ADCs of an IGN DNA cross-linker and DNA alkylator. Figure S2B. In vitro potency comparing ADCs of an IGN DNA cross-linker and DNA alk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f568423d203af13cedff0663cdc34a8
https://doi.org/10.1158/1535-7163.22504929.v1
https://doi.org/10.1158/1535-7163.22504929.v1
Autor:
Ravi V.J. Chari, Thomas A. Keating, Jan Pinkas, Olga Ab, Katharine C. Lai, Yelena Kovtun, Nicholas C. Yoder, Jose F. Ponte, Rajeeva Singh, Luke Harris, Dilrukshi Vitharana, Chen Bai, Katie E. Archer, Qifeng Qiu, Lauren Harvey, Erin K. Maloney, Surina Sikka, Leanne Lanieri, Emily E. Reid, Paulin Salomon, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6fcae1da3f382759fcd9ae562eb2f6
https://doi.org/10.1158/1535-7163.22504926.v1
https://doi.org/10.1158/1535-7163.22504926.v1
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Figure S1. Comparison of the rate of adduct formation of the indolinobenzodiazepine dimer 6 and the pyrrolobenzodiazepine dimer SJG-136 with dsDNA prepared from annealing of single strand DNA 3'-TATAGATCTATA-5'. Figure S2. A, In vitro potency of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8679b5302ba5296c6d41da8fcd17ee
https://doi.org/10.1158/1535-7163.22508395
https://doi.org/10.1158/1535-7163.22508395
Autor:
Sherry Pierce, Sa A. Wang, Marina Konopleva, Sergej Konoplev, Patrick A. Zweidler-McKay, Hagop M. Kantarjian, Elias Jabbour, Haitham Khogeer, Naval Daver, Joseph D. Khoury, Evgeniya Angelova, Charlene Audette, Jeffrey L. Jorgensen, Yelena Kovtun, L. Jeffrey Medeiros
Publikováno v:
Haematologica
The potential of CD123-targeted therapies in acute lymphoblastic leukemia/lymphoma remains largely unexplored. We examined CD123 expression levels in a large cohort of patients with acute lymphoblastic leukemia/lymphoma and assessed the in vitro impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43de0f6a219a1a788bcecf135efebf5
https://doi.org/10.3324/haematol.2018.205252
https://doi.org/10.3324/haematol.2018.205252