Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yelena Khakham"'
Autor:
Mark F. van Delft, Meng Xiao Luo, Kate McArthur, Peter E. Czabotar, Jarrod J. Sandow, Laura F. Dagley, Kym N Lowes, Jason M. Brouwer, Andrew I. Webb, Guillaume Lessene, Rachael M. Lane, Keith G. Watson, Christoph Grohmann, Ahmad Wardak, Peter M. Colman, Sabrina Bernard, Soo San Wan, Yelena Khakham, Phillip P. Sharp, Romina Lessene, Thao Nguyen, David J. Segal, David C.S. Huang, Erinna F. Lee, Lucy Li, Marlyse A. Debrincat, Grant Dewson, Chinh T. Bui, Hui San Chin, W. Douglas Fairlie, Stephane Duflocq, Benjamin T. Kile, Stephane Chappaz, Caroline Miles, Kurt Lackovic, Laure Peilleron
Publikováno v:
Nature Chemical Biology. 15:1057-1066
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f8a84e9d19f8763b3963c4941664e3
https://doi.org/10.1038/s41589-019-0365-8
https://doi.org/10.1038/s41589-019-0365-8
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 4, Pp o819-o819 (2009)
The title molecule, C20H31NO8, has pseudo-C2 symmetry about the C—N bond, with the bis(tert-butoxycarbonyl)amino group twisted from the benzene ring plane by ca 60° and the bulky tert-butoxycarbonyl (Boc) groups are orientated away from the substi
Externí odkaz:
https://doaj.org/article/42c70d98083c4779b73f999116c30525
Autor:
Frederick Masson, Tracy L Putoczki, Oliver M. Sieber, Yelena Khakham, Cary Tsui, Lotta Burstroem, Ashleigh R Poh, Matthias Ernst, Clifford A. Lowell, Robert J.J. O'Donoghue, Adele Preaudet, Lachlan Whitehead, Guillaume Lessene, Simon Monard, Christopher G. Love
Publikováno v:
Cancer Cell
Cancer Cell, Elsevier, 2017, 31 (4), pp.563-575.e5. ⟨10.1016/j.ccell.2017.03.006⟩
Cancer cell, vol 31, iss 4
Cancer Cell, Elsevier, 2017, 31 (4), pp.563-575.e5. ⟨10.1016/j.ccell.2017.03.006⟩
Cancer cell, vol 31, iss 4
International audience; Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) triggers hematological malignancies as a tumor cell-intrinsic oncogene. Here we find that high HCK levels correlate with reduced survival of colorect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ccf5f96a12fd1b191d8e1ab5515751
https://europepmc.org/articles/PMC5479329/
https://europepmc.org/articles/PMC5479329/
Autor:
Mark F, van Delft, Stephane, Chappaz, Yelena, Khakham, Chinh T, Bui, Marlyse A, Debrincat, Kym N, Lowes, Jason M, Brouwer, Christoph, Grohmann, Phillip P, Sharp, Laura F, Dagley, Lucy, Li, Kate, McArthur, Meng-Xiao, Luo, Hui San, Chin, W Douglas, Fairlie, Erinna F, Lee, David, Segal, Stephane, Duflocq, Romina, Lessene, Sabrina, Bernard, Laure, Peilleron, Thao, Nguyen, Caroline, Miles, Soo San, Wan, Rachael M, Lane, Ahmad, Wardak, Kurt, Lackovic, Peter M, Colman, Jarrod J, Sandow, Andrew I, Webb, Peter E, Czabotar, Grant, Dewson, Keith G, Watson, David C S, Huang, Guillaume, Lessene, Benjamin T, Kile
Publikováno v:
Nature chemical biology. 15(11)
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0477b40e4e5384654fad1f5b446d351b
https://pubmed.ncbi.nlm.nih.gov/31591564
https://pubmed.ncbi.nlm.nih.gov/31591564
Autor:
Oliver D. Montagnat, Jonathan B. Baell, Kasiram Katneni, Sandra Duffy, Yelena Khakham, Andrew B. Hughes, Vicky M. Avery, Kung Ban, Eileen Ryan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6024-6029
We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042afd7dd5afef07d1fd34a2b644ec3e
https://doi.org/10.1016/j.bmcl.2010.08.065
https://doi.org/10.1016/j.bmcl.2010.08.065
Publikováno v:
Org. Biomol. Chem.. 9:656-658
Rapid and high yielding synthesis of medium ring lactams was made possible through the use of a benzoylurea auxiliary that serves to stabilize a cisoid amide conformation, facilitating cyclization. The auxiliary is released after activation under the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbdec14beaef112ea3fed288b71a011
https://doi.org/10.1039/c0ob00723d
https://doi.org/10.1039/c0ob00723d
Autor:
Jessica K. Holien, Mads Gyrd-Hansen, Guillaume Lessene, Katherine A Jackman, Michael W. Parker, Sabrina Mühlen, Phillip P. Sharp, Yelena Khakham, James E Vince, Diep Chau, Jarrod J. Sandow, John Silke, Aleksandra Bankovacki, David C.S. Huang, Hendrik Falk, Che A. Stafford, Elizabeth L. Hartland, Lisa M Lindqvist, Yifan Zhan, Hyun-Ja Ko, Catherine Kennedy, Ueli Nachbur, Andrew I. Webb, Andrew M. Lew, Kym N Lowes, Berthe Katrine Fiil, Joanne M Hildebrand, James M. Murphy
Publikováno v:
Nature communications
Intracellular nucleotide binding and oligomerization domain (NOD) receptors recognize antigens including bacterial peptidoglycans and initiate immune responses by triggering the production of pro-inflammatory cytokines through activating NF-κB and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935b1e92d5c688de878e34c4aab7642d
https://pubmed.ncbi.nlm.nih.gov/25778803
https://pubmed.ncbi.nlm.nih.gov/25778803
Publikováno v:
ChemInform. 42
The benzoylurea auxiliary in (I) and (IV) facilitate the formation of macrocyclic lactams via stabilization of a cisoid amide bond, promoting rapid and high yielding ring closure via ring closing metathesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccb9eff9b326a029984f46ea78de3fe1
https://doi.org/10.1002/chin.201121172
https://doi.org/10.1002/chin.201121172
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 4, Pp o819-o819 (2009)
Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E: Structure Reports
The title molecule, C20H31NO8, has pseudo-C2 symmetry about the C—N bond, with the bis(tert-butoxycarbonyl)amino group twisted from the benzene ring plane by ca 60° and the bulky tert-butoxycarbonyl (Boc) groups are orientated away from the substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0ec89e5b272afc0d3dd86eef1ae138
http://scripts.iucr.org/cgi-bin/paper?S1600536809009246
http://scripts.iucr.org/cgi-bin/paper?S1600536809009246
Publikováno v:
Current medicinal chemistry. 15(7)
Platensimycin was recently discovered by Merck Research Laboratories and has created considerable interest given its potent antibacterial activity and mode of action. The use of RNA gene-silencing techniques and screening libraries of natural product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aceb5bd15641087817c1a4915c1d8274
https://pubmed.ncbi.nlm.nih.gov/18336284
https://pubmed.ncbi.nlm.nih.gov/18336284