Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yelena Karpova"'
Autor:
Daniele Baiz, Sazzad Hassan, Young A Choi, Anabel Flores, Yelena Karpova, Dana Yancey, Ashok Pullikuth, Guangchao Sui, Michel Sadelain, Waldemar Debinski, George Kulik
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 10, Pp 1172-1183 (2013)
The phosphoinositide 3-kinase (PI3K) pathway is activated in most advanced prostate cancers, yet so far treatments with PI3K inhibitors have been at best tumorostatic in preclinical cancer models and do not show significant antitumor efficacy in clin
Externí odkaz:
https://doaj.org/article/c2df14a32dce4f9e9827a6cedeb37d60
Publikováno v:
Molecules, Vol 23, Iss 7, p 1675 (2018)
A number of new substituted morpholinopyrimidines were prepared utilizing sequential nucleophilic aromatic substitution and cross-coupling reactions. One of the disubstituted pyrimidines was converted into two trisubstituted compounds which were scre
Externí odkaz:
https://doaj.org/article/a4024fc6fa994409b76b59636227c676
Autor:
Dana Yancey, Kyle C Nelson, Daniele Baiz, Sazzad Hassan, Anabel Flores, Ashok Pullikuth, Yelena Karpova, Linara Axanova, Victoria Moore, Guangchao Sui, George Kulik
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74561 (2013)
PTEN loss and constitutive activation of the PI3K signaling pathway have been associated with advanced androgen-independent prostate cancer. PTEN-deficient prostate cancer C42Luc cells survive in serum-free media and show relative resistance to apopt
Externí odkaz:
https://doaj.org/article/c48b7283e0894306b04104a460234899
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78175 (2013)
Androgens control growth of prostate epithelial cells and androgen deprivation induces apoptosis, leading to prostate involution. We investigated the effects of surgical stress on prostate involution induced by androgen ablation and determined the un
Externí odkaz:
https://doaj.org/article/7a959ad2d9284c9ca3ac7cfef4e79db5
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6224 (2009)
BAD, a pro-apoptotic protein of the Bcl-2 family, has recently been identified as an integrator of several anti-apoptotic signaling pathways in prostate cancer cells. Thus, activation of EGFR, GPCRs or PI3K pathway leads to BAD phosphorylation and in
Externí odkaz:
https://doaj.org/article/41c44eef88b442a99d4371fd9d68bf19
Autor:
George Kulik, Waldemar Debinski, Urs von Holzen, Ashok Hemal, Ralph D'Agostino, Young A. Choi, Yue Huang, Guangchao Sui, Sinan Zhu, Daniele Baiz, Yelena Karpova, Anabel Flores, Kyle C. Nelson, Ashok Pullikuth, Sazzad Hassan
There is accumulating evidence that continuous activation of the sympathetic nervous system due to psychosocial stress increases resistance to therapy and accelerates tumor growth via β2-adrenoreceptor signaling (ADRB2). However, the effector mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80c5b6b33e58667e3d74e3ead11c999b
https://doi.org/10.1158/1541-7786.c.6541105
https://doi.org/10.1158/1541-7786.c.6541105
Publikováno v:
Molecules
Volume 23
Issue 7
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 7, p 1675 (2018)
Volume 23
Issue 7
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 7, p 1675 (2018)
A number of new substituted morpholinopyrimidines were prepared utilizing sequential nucleophilic aromatic substitution and cross-coupling reactions. One of the disubstituted pyrimidines was converted into two trisubstituted compounds which were scre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c66dd3cfa2dbcab80c26e1d6882c2f
Autor:
George Kulik, Yelena Karpova, Suzanne C. Danhauer, Ashok K. Hemal, Sazzad Hassan, Ralph B. D'Agostino, Anabel Flores
Publikováno v:
International Urology and Nephrology. 46:505-510
In mouse models of prostate cancer, increased epinephrine levels accelerated tumor growth via the beta2-adrenoreceptor/PKA signaling pathway. It is unknown, however, whether men experience increased epinephrine levels sufficient to activate the beta2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d71cf6afc471a3e5ba62a3bdf7c984f
https://doi.org/10.1007/s11255-013-0513-0
https://doi.org/10.1007/s11255-013-0513-0
Autor:
Mark E. Welker, Freddie R. Salsbury, Tanya A. Pinder, Yelena Karpova, Daniele Baiz, Sazzad Hassan, George Kulik
Publikováno v:
Journal of Medicinal Chemistry. 55:8038-8046
The phosphatidylinositol-3-kinase/Akt (PI3K/Akt) pathway is constitutively activated in a substantial proportion of prostate tumors and is considered a key mechanism supporting progression toward an androgen-independent status, for which no effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf4128648fba1e411cbc2db7cb75d71
https://doi.org/10.1021/jm300881a
https://doi.org/10.1021/jm300881a
Autor:
Adrienne J. Smith, Brian Essau, George Kulik, Jonathan P. Carson, Yelena Karpova, Thomas C. Register, Yong Q. Chen, Raymond B. Penn, Sergey Prokopovich, Michael J. Weber, Avynash Gersappe, Konduru S.R. Sastry
Publikováno v:
Journal of Biological Chemistry. 282:14094-14100
The stress hormone epinephrine is known to elicit multiple systemic effects that include changes in cardiovascular parameters and immune responses. However, information about its direct action on cancer cells is limited. Here we provide evidence that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38695d1624fe81b0cf6c72748c0311bf
https://doi.org/10.1074/jbc.m611370200
https://doi.org/10.1074/jbc.m611370200