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pro vyhledávání: '"Yejin Esther Yun"'
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 172 (2022)
The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults. The objectives of this study were: (i) to provide a comprehensive review of the age-depe
Externí odkaz:
https://doaj.org/article/43f9305030f642b5a258a94cf602c45c
Autor:
Andrea N. Edginton, Yejin Esther Yun
Pediatric physiologically based pharmacokinetic (PBPK) models facilitate the prediction of PK parameters in children under specific exposure conditions. Pharmacokinetic outcomes are highly sensitive to fraction unbound in plasma (fup) as incorporated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325c3af97048af6e9fbb09a2b1b1cfda
Autor:
Andrea N. Edginton, Yejin Esther Yun
Publikováno v:
Computational Toxicology. 18:100168
In human health risk assessment, pediatric physiologically-based pharmacokinetic modeling has been used to predict chemical-specific toxicokinetic adjustment factors. An important input parameter fraction unbound in plasma in child (fupchild) can be
Autor:
Yejin Esther Yun, Andrea N. Edginton, Rogelio Tornero-Velez, Daniel T. Chang, S. Thomas Purucker
Publikováno v:
Comput Toxicol
The extent of plasma protein binding is an important compound-specific property that influences a compound's pharmacokinetic behavior and is a critical input parameter for predicting exposure in physiologically based pharmacokinetic (PBPK) modeling.
Autor:
Yejin Esther Yun, Andrea N. Edginton
Pediatric physiologically based pharmacokinetic (PBPK) models facilitate the estimation of pharmacokinetic (PK) parameters in children under specific exposure conditions. In human health risk assessment, PBPK modeling has been used to determine a che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3e7a1ef6ca4f0e329b7941f3b6ac49
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 41:1-14
Physiologically based pharmacokinetic (PBPK) modeling is a tool used in drug discovery and human health risk assessment. PBPK models are mathematical representations of the anatomy, physiology and biochemistry of an organism and are used to predict a