Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yejin Chang"'
Publikováno v:
Chem. 8:1805-1821
Radical chemistry has emerged as a cornerstone in modern organic synthesis, providing chemists with numerous new tools to rapidly expand reactivity and chemical space in academic and industrial research. In this regard, titanium complexes have been r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdf2b4690e41d41f18918aabe4d7f06
https://doi.org/10.1016/j.chempr.2022.06.005
https://doi.org/10.1016/j.chempr.2022.06.005
Publikováno v:
Journal of the American Chemical Society. 143:2441-2455
We disclose a catalytic method for β-C(sp3)-H functionalization of N-alkylamines for the synthesis of enantiomerically enriched β-substituted amines, entities prevalent in pharmaceutical compounds and used to generate different families of chiral c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9050a8006b7a298ac3c5c90fc09236f8
https://doi.org/10.1021/jacs.0c13200
https://doi.org/10.1021/jacs.0c13200
Publikováno v:
Organic Letters. 21:984-988
An efficient method for the coupling of N-alkylamines with silicon enolates to generate β-amino carbonyl compounds is disclosed. These reactions proceed by activation of α-amino C–H bonds by B(C(6)F(5))(3), which likely generates a “frustrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3354ba5e23c08a8731c63c370fcdc3c0
https://doi.org/10.1021/acs.orglett.8b03959
https://doi.org/10.1021/acs.orglett.8b03959
Autor:
Yejin, Chang, Min, Cao, Jessica Z, Chan, Cunyuan, Zhao, Yuankai, Wang, Rose, Yang, Masayuki, Wasa
Publikováno v:
J Am Chem Soc
We disclose a catalytic method for β-C(sp(3))–H functionalization of N-alkylamines for synthesis of enantiomerically enriched β-substituted amines, entities prevalent in pharmaceutical compounds and used to generate different families of chiral c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4e5ad29aa203245c733ba4c5e08ed90
https://pubmed.ncbi.nlm.nih.gov/33512998
https://pubmed.ncbi.nlm.nih.gov/33512998
An efficient deuteration process of α-C–H bonds in various carbonyl-based pharmaceutical compounds has been developed. Catalytic reactions are initiated by the action of Lewis acidic B(C(6)F(5))(3) and D(2)O, converting a drug molecule into the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7862df50079614a521b16ea1c9fffe
https://europepmc.org/articles/PMC7108789/
https://europepmc.org/articles/PMC7108789/
Autor:
Min Cao, Bochao Zhang, Masayuki Wasa, Yejin Chang, Yuyang Zhang, Ahmet Yesilcimen, Jessica Z. Chan
Publikováno v:
Journal of the American Chemical Society. 141(37)
An efficient deuteration process of β-amino C─H bonds in various N-alkylamine-based pharmaceutical compounds has been developed. Catalytic reactions begin with the action of Lewis acidic B(C(6)F(5))(3) and Brønsted basic N-alkylamine, converting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98e9f8fdf4b31bd80f899eb13b76560
https://pubmed.ncbi.nlm.nih.gov/31480842
https://pubmed.ncbi.nlm.nih.gov/31480842
Autor:
Yejin Chang, Jessica Z. Chan, Ming Shang, Masayuki Wasa, Qifan Wang, Min Cao, Sebastian Torker, Brennan Cook
Catalytic transformations of α-amino C–H bonds to afford valuable enantiomerically enriched α-substituted amines, entities that are prevalent in pharmaceuticals and bioactive natural products, have been developed. Typically, such processes are ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66327bdb125738cfca32b098f1c60b6
https://europepmc.org/articles/PMC6542567/
https://europepmc.org/articles/PMC6542567/