Zobrazeno 1 - 10 of 50 pro vyhledávání: '"Yejia Song"'
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Akademický článek
Basal late sodium current is a significant contributor to the duration of action potential of guinea pig ventricular myocytes
Autor: Yejia Song, Luiz Belardinelli
Publikováno v: Physiological Reports, Vol 5, Iss 10, Pp n/a-n/a (2017)
Abstract In cardiac myocytes, an enhancement of late sodium current (INaL) under pathological conditions is known to cause prolongation of action potential duration (APD). This study investigated the contribution of INaL under basal, physiological co
Externí odkaz: https://doaj.org/article/a0b04be9030b47258ed401aba4d49130
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Enhanced basal late sodium current appears to underlie the age-related prolongation of action potential duration in guinea pig ventricular myocytes
Autor: Yejia Song, Luiz Belardinelli
Publikováno v: Journal of Applied Physiology. 125:1329-1338
Aging hearts have prolonged QT interval and are vulnerable to oxidative stress. Because the QT interval indirectly reflects the action potential duration (APD), we examined the hypotheses that 1) the APD of ventricular myocytes increases with age; 2)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88400f2aafd8abe471803af96ea472dd
https://doi.org/10.1152/japplphysiol.00916.2017
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Modulation of late sodium current by Ca2+-calmodulin-dependent protein kinase II, protein kinase C and Ca2+during hypoxia in rabbit ventricular myocytes
Autor: Jihua Ma, Zhenzhen Cao, Mengliu Zeng, Yejia Song, Antao Luo, Chen Fu, Jie Hao, Wanzhen Jiang, Luiz Belardinelli, Peihua Zhang
Publikováno v: Experimental Physiology. 102:818-834
NEW FINDINGS What is the central question of this study? Hypoxia-induced increase in late sodium current (INa,L ) is associated with conditions causing cellular Ca2+ overload and contributes to arrhythmogenesis in the ventricular myocardium. The INa,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56effc2a6acc4489ba0dcc0c2fb970fd
https://doi.org/10.1113/ep085990
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5
A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+current
Autor: Pei Chi Yang, Wayne R. Giles, Colleen E. Clancy, Balázs Horváth, Sridharan Rajamani, Ye Chen-Izu, Luiz Belardinelli, Yejia Song
Publikováno v: The Journal of Physiology. 593:1429-1442
Key points The ventricular action potential plateau is a phase of high resistance, which makes ventricular myocytes vulnerable to small electrical perturbations. We developed a computationally based model of GS-458967 interaction with the cardiac Na+
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ceb0d4c59cef8706774f553f8edb922b
https://doi.org/10.1113/jphysiol.2014.279554
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The arrhythmogenic consequences of increasing late INa in the cardiomyocyte
Autor: Yejia Song, John C. Shryock, Sridharan Rajamani, Charles Antzelevitch, Luiz Belardinelli
Publikováno v: Cardiovascular Research. 99:600-611
This review presents the roles of cardiac sodium channel NaV1.5 late current (late INa) in generation of arrhythmic activity. The assumption of the authors is that proper Na(+) channel function is necessary to the maintenance of the transmembrane ele
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9411e0ce15c277a7107210a662924f
https://doi.org/10.1093/cvr/cvt145
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The Late Na+ Current (INa) Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late INa and Cause Ventricular Diastolic Dysfunction
Autor: Yejia Song, John C. Shryock, Yuzhi Wu, Luiz Belardinelli
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 330:550-557
Palmitoyl-L-carnitine (PC), an ischemic metabolite, causes cellular Na(+) and Ca(2+) overload and cardiac dysfunction. This study determined whether ranolazine [(+/-)-1-piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)prop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e0e8ec7b81741d99a523bb659e7ecd
https://doi.org/10.1124/jpet.109.151936
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Abstract 17193: Inhibiting Late Sodium Current Attenuates Isoproterenol-Induced Transient Inward Current and Delayed Afterdepolarizations in Ventricular Myocytes
Autor: Yejia Song, Nesrine El-Bizri, Sridharan Rajamani, Luiz Belardinelli
Publikováno v: Circulation. 132
Introduction: The β-adrenergic agonist isoproterenol (ISO) is known to induce the arrhythmogenic transient inward current (I Ti ) and delayed afterdepolarization (DAD) via a stimulation of L-type Ca 2+ current. Recent studies found that ISO-induced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f37f3c9abcb8e191fa20efbbf3e62f3
https://doi.org/10.1161/circ.132.suppl_3.17193
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Abstract 17251: Enhanced Late Sodium Current Predisposes Cardiomyocytes From Aged Guinea Pigs to the Arrhythmogenic Effects of Hydrogen Peroxide
Autor: Yejia Song, Sridharan Rajamani, Luiz Belardinelli
Publikováno v: Circulation. 132
Introduction Aging is associated with both a decreased tolerance to oxidative stress and an increased incidence of cardiac arrhythmias. This study examined the hypotheses that 1) ventricular myocytes from aged guinea pigs (GPs) are more susceptible t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3db2530ba3a64a9d813fc435c8c852ab
https://doi.org/10.1161/circ.132.suppl_3.17251
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