Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Yehuda Shavit"'
Publikováno v:
Experimental Neurology. 275:133-142
Wind-up (WU) is a progressive, frequency-dependent facilitation of spinal cord neurons in response to repetitive nociceptive stimulation of constant intensity. We identified a new WU-associated phenomenon in naïve mice (not exposed to noxious stimul
Publikováno v:
Anesthesia & Analgesia. 115:934-943
Reports regarding the ability of the anesthetic drug ketamine to attenuate the inflammatory response to surgery are conflicting. In this systematic review we examined the effect of perioperative ketamine administration on postoperative inflammation a
Publikováno v:
QJM. 104:933-938
Aim: To find out which of the two predictors, Charlson co-morbidity index or vitamin B12, better estimates the risk of in-hospital mortality in seriously ill patients. Method: Electronic hospital records of 1509 elderly patients aged 65 and older wer
Publikováno v:
European Journal of Pain. 15:242-248
Neuropathic pain is a chronic pain state resulting from peripheral nerve injury, characterized by hyperalgesia and allodynia. We have reported that mice with genetic impairment of IL-1 signaling display attenuated neuropathic pain behavior and ectopi
Publikováno v:
Brain, Behavior, and Immunity. 22:1072-1077
Postoperative incisional pain is characterized by persistent acute pain in the area of the cut, and is associated with release of proinflammatory cytokines, including interleukin-1 (IL-1), which play important hyperalgesic and allodynic roles in vari
Autor:
Cobi Jacoba Johanna Heijnen, Nadav Ziv, Wendy Kleibeuker, Eran Gabay, Michael Tal, Yehuda Shavit, Gilly Wolf, Jitske Zijlstra, Raz Yirmiya, Annemieke Kavelaars
Publikováno v:
Brain, Behavior, and Immunity. 22:200-208
Many neurotransmitters involved in pain perception transmit signals via G protein-coupled receptors (GPCRs). GPCR kinase 2 (GRK2) regulates agonist-induced desensitization and signaling of multiple GPCRs and interacts with downstream molecules with c
Autor:
Tirzah Kreisel, Joseph Weidenfeld, Gilly Wolf, Stephen Poole, Yehuda Shavit, Raz Yirmiya, Inbal Goshen
Publikováno v:
Brain, Behavior, and Immunity. 21:652-659
Exposure to stressful stimuli is often accompanied by reduced pain sensitivity, termed "stress-induced analgesia" (SIA). In the present study, the hypothesis that interleukin-1 (IL-1) may play a modulatory role in SIA was examined. Two genetic mouse
Publikováno v:
Neuroscience Letters. 404:154-158
Interleukin-1 beta (IL-1beta) and its endogenous IL-1 receptor antagonist (IL-1Ra) play an important role in inflammatory response and in pain modulation. It has recently been shown that polymorphism of the IL-1beta and IL-1Ra genes may account for v
Autor:
Yehuda Shavit, Yael Lavi-Avnon, O. Malkesman, Gilly Wolf, Michal Shayit, Mariana Schroeder, Raz Yirmiya, Aron Weller, Y. Stern, Itay Hurwitz
Publikováno v:
Peptides. 27:1483-1489
CCK involvement in stress- and pain-responsiveness was examined by studying the beha- vior of infant (11-12-days-old) and adult OLETF rats that do not express CCK1 receptors. Infant odor- and texture-preferences were also assessed. We hypothesized th
Publikováno v:
Neuroimmunomodulation. 13:36-42
Background: This study examined the role of glucocorticoids (GC) and interleukin-1 (IL-1) in regulating the production of brain prostaglandin E2 (PGE2) in response to surgical stress. Methods: Surgical stress was induced in rats by laparotomy or expl