Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Yehuda Goldgur"'
Autor:
Aaron Gupta, Kevin S. Kao, Rachel Yamin, Deena A. Oren, Yehuda Goldgur, Jonathan Du, Pete Lollar, Eric J. Sundberg, Jeffrey V. Ravetch
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Immunoglobulin G (IgG) antibodies contain a complex N-glycan embedded in the hydrophobic pocket between its heavy chain protomers. This glycan contributes to the structural organization of the Fc domain and determines its specificity for Fc
Externí odkaz:
https://doaj.org/article/0c91ddacfecf4f7fb89461122325693e
Autor:
Nayanendu Saha, Du-San Baek, Rachelle P. Mendoza, Dorothea Robev, Yan Xu, Yehuda Goldgur, M. Jason De La Cruz, Elisa de Stanchina, Peter W. Janes, Kai Xu, Dimiter S. Dimitrov, Dimitar B. Nikolov
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114494- (2023)
Metastasis and chemoresistance in colorectal cancer are mediated by certain poorly differentiated cancer cells, known as cancer stem cells, that are maintained by Notch downstream signaling initiated upon Notch cleavage by the metalloprotease ADAM10.
Externí odkaz:
https://doaj.org/article/b712523716ad44dfa195b6194a09bf60
Autor:
Bradley Benjamin, Yehuda Goldgur, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Expression of the fission yeast Schizosaccharomyces pombe phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate signaling molecule 1,5-IP8. IP8 dynamics are determined by Asp1, a bifunctional enzyme consisti
Externí odkaz:
https://doaj.org/article/05a2bc5f0397413b89f734e199a4c266
Autor:
Gerard Minuesa, Steven K. Albanese, Wei Xie, Yaniv Kazansky, Daniel Worroll, Arthur Chow, Alexandra Schurer, Sun-Mi Park, Christina Z. Rotsides, James Taggart, Andrea Rizzi, Levi N. Naden, Timothy Chou, Saroj Gourkanti, Daniel Cappel, Maria C. Passarelli, Lauren Fairchild, Carolina Adura, J. Fraser Glickman, Jessica Schulman, Christopher Famulare, Minal Patel, Joseph K. Eibl, Gregory M. Ross, Shibani Bhattacharya, Derek S. Tan, Christina S. Leslie, Thijs Beuming, Dinshaw J. Patel, Yehuda Goldgur, John D. Chodera, Michael G. Kharas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.
Externí odkaz:
https://doaj.org/article/0841d30974ee49439a137cb5c41e499b
Autor:
Ankan Banerjee, Annum Munir, Leonora Abdullahu, Masad J. Damha, Yehuda Goldgur, Stewart Shuman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Tpt1 catalyzes the final essential step in yeast tRNA splicing and is a potential antifungal target. Here the authors provide structural insights into how Tpt1 recognizes a 2’-PO4 RNA splice junction and the mechanism of RNA phospho-ADP-ribosylatio
Externí odkaz:
https://doaj.org/article/cdd75b7ad930479491bcd6cb6ab91951
Autor:
Emilia O Mason, Yehuda Goldgur, Dorothea Robev, Andrew Freywald, Dimitar B Nikolov, Juha P Himanen
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247335 (2021)
Eph receptors are the largest group amongst the receptor tyrosine kinases and are divided into two subgroups, A and B, based on ligand binding specificities and sequence conservation. Through ligand-induced and ligand-independent activities, Ephs pla
Externí odkaz:
https://doaj.org/article/33a68ea70da940d5bd84d6e4586d92aa
Autor:
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 62-75.e7 (2019)
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to
Externí odkaz:
https://doaj.org/article/95d35ea0d3dd4fce8521d6c45f7d1b30
Autor:
Sabine Topka, Joseph Vijai, Michael F Walsh, Lauren Jacobs, Ann Maria, Danylo Villano, Pragna Gaddam, Gang Wu, Rose B McGee, Emily Quinn, Hiroto Inaba, Christine Hartford, Ching-Hon Pui, Alberto Pappo, Michael Edmonson, Michael Y Zhang, Polina Stepensky, Peter Steinherz, Kasmintan Schrader, Anne Lincoln, James Bussel, Steve M Lipkin, Yehuda Goldgur, Mira Harit, Zsofia K Stadler, Charles Mullighan, Michael Weintraub, Akiko Shimamura, Jinghui Zhang, James R Downing, Kim E Nichols, Kenneth Offit
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005262 (2015)
Somatic mutations affecting ETV6 often occur in acute lymphoblastic leukemia (ALL), the most common childhood malignancy. The genetic factors that predispose to ALL remain poorly understood. Here we identify a novel germline ETV6 p. L349P mutation in
Externí odkaz:
https://doaj.org/article/857b67bb97a141dd80ae77fd0dd250d4
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63359 (2013)
Ganglioside GD2 is a cell surface glycolipid that is highly expressed on cancer cells of neuroectodermal origin, including neuroblastoma, retinoblastoma, melanoma, sarcomas, brain tumors and small cell lung cancer. Monoclonal antibodies (MoAb) that t
Externí odkaz:
https://doaj.org/article/3cb65e90811e4ea2b1ccebc1c107c4ee
Autor:
Aaron Gupta, Kevin Kao, Rachel Yamin, Deena A. Oren, Yehuda Goldgur, Jonathan Du, Pete Lollar, Eric J. Sundberg, Jeffrey V. Ravetch
Publikováno v:
bioRxiv
Immunoglobulin G (IgG) antibodies contain a single, complexN-glycan on each IgG heavy chain protomer embedded in the hydrophobic pocket between its Cγ2 domains. The presence of this glycan contributes to the structural organization of the Fc domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d00b0aa47feb6f055236887987e03e
https://doi.org/10.1101/2023.01.23.525277
https://doi.org/10.1101/2023.01.23.525277