Výsledky vyhledávání - "Yehia Marreez"

Cardiomyocyte Degeneration With Calpain Deficiency Reveals a Critical Role in Protein Homeostasis

Autor: Harvey S. Hahn, Hanna Osinska, Yehia Marreez, Roy A. Lynch, Jaime Melendez, Amy M. Odley, Gerald W. Dorn, Anita Gálvez, Jeffrey Robbins, Abhinav Diwan

Publikováno v: Circulation Research. 100:1071-1078

Regulating the balance between synthesis and proteasomal degradation of cellular proteins is essential for tissue growth and maintenance, but the critical pathways regulating protein ubiquitination and degradation are incompletely defined. Although p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902bc723ab615de17e55a10523b155ec
https://doi.org/10.1161/01.res.0000261938.28365.11

Zobrazit plný text záznamu

Cardiac-Specific Ablation of G-Protein Receptor Kinase 2 Redefines Its Roles in Heart Development and β-Adrenergic Signaling

Autor: Abhinav Diwan, Amy M. Odley, Justin L. Klanke, Scot J. Matkovich, Eric W. Brunskill, Yehia Marreez, Daniel J. Hammer, Walter J. Koch, Robert J. Schwartz, Gerald W. Dorn

Publikováno v: Circulation Research. 99:996-1003

G-protein receptor kinase 2 (GRK2) is 1 of 7 mammalian GRKs that phosphorylate ligand-bound 7-transmembrane receptors, causing receptor uncoupling from G proteins and potentially activating non–G-protein signaling pathways. GRK2 is unique among mem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c4902c029106f54ff0deaab91ec67e
https://doi.org/10.1161/01.res.0000247932.71270.2c

Zobrazit plný text záznamu

Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function

Autor: Prabhu A. Padmanabhan, Kenneth S. Ginsburg, Kimberly N. Gregory, Bryan Mitton, Harvey S. Hahn, Woo Jin Park, Federica del Monte, Qiujing Song, Yehia Marreez, Jason R. Waggoner, Ilona Bodi, Donald M. Bers, Gerald W. Dorn, Evangelia G. Kranias

Publikováno v: Journal of Molecular and Cellular Cardiology. 40:653-665

Defects in the pathways that regulate cardiac sarcoplasmic reticulum (SR) calcium (Ca) cycling represent prime targets for driving the deterioration of function and progression to heart failure. We hypothesized that the histidine-rich Ca binding prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52b04ad8801862a9b31e29e91968b95
https://doi.org/10.1016/j.yjmcc.2006.02.003

Zobrazit plný text záznamu

Enhancement of Cardiac Function and Suppression of Heart Failure Progression By Inhibition of Protein Phosphatase 1

Publikováno v: Circulation Research. 96:756-766

Abnormal calcium cycling, characteristic of experimental and human heart failure, is associated with impaired sarcoplasmic reticulum calcium uptake activity. This reflects decreases in the cAMP-pathway signaling and increases in type 1 phosphatase ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90bfd3f4ae9a57cb4c7dde59379e407
https://doi.org/10.1161/01.res.0000161256.85833.fa

Zobrazit plný text záznamu

Physiological Growth Synergizes With Pathological Genes in Experimental Cardiomyopathy

Autor: Roy A. Lynch, Jeffrey Robbins, Harvey S. Hahn, Atsushi Sanbe, Gerald W. Dorn, Eric W. Brunskill, Amy Odley, Yehia Marreez, Faisal Syed

Publikováno v: Circulation Research. 95:1200-1206

Hundreds of signaling molecules have been assigned critical roles in the pathogenesis of myocardial hypertrophy and heart failure based on cardiac phenotypes from α-myosin heavy chain–directed overexpression mice. Because permanent ventricular tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35f5768d8bbc1d01a5554a6837dd600
https://doi.org/10.1161/01.res.0000150366.08972.7f

Zobrazit plný text záznamu

Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy

Autor: Amber Sterbling, K. Chad Hilty, Arnold Schwartz, Gerald W. Dorn, Harvey S. Hahn, Stephen B. Liggett, Ilona Bodi, Yehia Marreez, Martin G. Yussman, Amy M. Odley

Publikováno v: Circulation Research. 93:1111-1119

The protein kinase C (PKC) family is implicated in cardiac hypertrophy, contractile failure, and beta-adrenergic receptor (betaAR) dysfunction. Herein, we describe the effects of gain- and loss-of-PKCalpha function using transgenic expression of conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ff771d83a6f933de7d5b332e821201
https://doi.org/10.1161/01.res.0000105087.79373.17

Zobrazit plný text záznamu

Abstract 635: Inhibiting Reactive Apoptosis by Cardiac-specific Nix Ablation Prevents Decompensation of Pathological Hypertrophy

Autor: Abhinav Diwan, Janaka Wansapura, Scot Matkovich, Faisal Syed, Hairong Li, Yehia Marreez, Gerald W Dorn

Publikováno v: Circulation. 116

Background : Compensated pathological hypertrophy will inevitably remodel, leading to functional decompensation. Postulated mechanisms include cardiomyocyte dropout, changes in myocardial matrix, and altered cardiac metabolism. Transcriptional modula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cb241791d2e7c7a7f2d6ed039978542
https://doi.org/10.1161/circ.116.suppl_16.ii_116-c

Zobrazit plný text záznamu

Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling

Autor: Yehia Marreez, Jeffrey Robbins, Harvey S. Hahn, Gerald W. Dorn, Hanna Osinska, Roy A. Lynch, Amy M. Odley

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 101(18)

Catecholaminergic activation of myocardial β-adrenergic receptors (βAR) is the principle mechanism regulating cardiac function. Agonists desensitize βAR through G protein-coupled receptor kinase-mediated uncoupling and β-arrestin-mediated interna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03edcbf876bbd5e6b802b306d3374ef6
https://pubmed.ncbi.nlm.nih.gov/15105445

Zobrazit plný text záznamu

Increased particulate partitioning of PKC epsilon reverses susceptibility of phospholamban knockout hearts to ischemic injury

Autor: Gerald W. Dorn, Evangelia G. Kranias, Amy M. Odley, Kobra Haghighi, Kimberly N. Gregory, Harvey S. Hahn, Yehia Marreez

Publikováno v: Journal of molecular and cellular cardiology. 36(2)

Cytosolic Ca(2+) overload is a critical mediator of myocardial damage following cardiac ischemia-reperfusion. It has therefore been proposed that normalization of sarcoplasmic reticulum Ca(2+) cycling through inhibition or ablation of the Ca(2+) ATP-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d5e2a95c9ed5fbb71790d53170e302
https://pubmed.ncbi.nlm.nih.gov/14871559

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání