Výsledky vyhledávání - "Yehia Elgammal"

Akademický článek

Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris

Autor: Ehab A. Salama, Yehia Elgammal, Aruna Wijeratne, Nadia A. Lanman, Sagar M. Utturkar, Atena Farhangian, Jianing Li, Brigitte Meunier, Tony R. Hazbun, Mohamed N. Seleem

Publikováno v: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

ABSTRACTCandida auris has emerged as a problematic fungal pathogen associated with high morbidity and mortality. Amphotericin B (AmB) is the most effective antifungal used to treat invasive fungal candidiasis, with resistance rarely observed among cl

Externí odkaz: https://doaj.org/article/86666a3c96ba42a690335fc3c94d13ce

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Akademický článek

Enhanced antifungal activity of posaconazole against Candida auris by HIV protease inhibitors, atazanavir and saquinavir

Autor: Yehia Elgammal, Ehab A. Salama, Mohamed N. Seleem

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract The increasing incidence and dissemination of multidrug-resistant Candida auris represents a serious global threat. The emergence of pan-resistant C. auris exhibiting resistance to all three classes of antifungals magnifies the need for nove

Externí odkaz: https://doaj.org/article/f6ef92f8552647208dd7786419a79700

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Atazanavir Resensitizes Candida auris to Azoles

Autor: Yehia Elgammal, Ehab A. Salama, Mohamed N. Seleem

Publikováno v: Antimicrobial Agents and Chemotherapy. 67

Candida auris represents an urgent health threat. Here, we identified atazanavir as a potent drug capable of resensitizing C. auris clinical isolates to the activity of azole antifungals.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbc86dd70752c6da5e694f8e97f4e3e1
https://doi.org/10.1128/aac.01631-22

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SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteria

Autor: Eman M.E. Dokla, Nader S. Abutaleb, Sandra N. Milik, Ezzat A.E.A. Kandil, Omar M. Qassem, Yehia Elgammal, Maha Nasr, Martin J. McPhillie, Khaled A.M. Abouzid, Mohamed N. Seleem, Peter Imming, Mai Adel

Publikováno v: European journal of medicinal chemistry. 247

Antibiotic-resistant bacteria represent a serious threat to modern medicine and human life. Only a minority of antibacterial agents are active against Gram-negative bacteria. Hence, the development of novel antimicrobial agents will always be a vital

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba4a1ec611a52d7fd16faa8aef904fd
https://pubmed.ncbi.nlm.nih.gov/36584632

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Structure–Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae

Autor: Amanda L. Graboski, Xufeng Cao, Yehia Elgammal, Devon P. Amos, Molly S. Youse, Alessio Nocentini, Nader S. Abutaleb, Anil Kumar Marapaka, Weiwei An, Mohamed N. Seleem, Claudiu T. Supuran, Ahmed E. M. Elhassanny, Katrina J. Holly, Chad S. Hewitt, Daniel P. Flaherty, Jatinder Kaur, Aaron D Krabill, Ahmed Elkashif

Publikováno v: ACS Infectious Diseases. 7:1969-1984

Neisseria gonorrhoeae is an urgent threat to public health in the United States and around the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are quickly becoming obsolete due to increased rates of resistance. Thu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::506c99f38b00123de518cee832d6beb7
https://doi.org/10.1021/acsinfecdis.1c00055

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