Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yeh Jun Lim"'
Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures
Autor:
Jinjian Hu, Wencheng Xia, Shuyi Zeng, Yeh-Jun Lim, Youqi Tao, Yunpeng Sun, Lang Zhao, Haosen Wang, Weidong Le, Dan Li, Shengnan Zhang, Cong Liu, Yan-Mei Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract α-Synuclein forms amyloid fibrils that are critical in the progression of Parkinson’s disease and serves as the pathological hallmark of this condition. Different posttranslational modifications have been identified at multiple sites of
Externí odkaz:
https://doaj.org/article/d8ea981108d54492b64dcfa30bf8679b
Autor:
Chuchu Wang, Meng Rong Ma, Houfang Long, Youqi Tao, Xiaobo Mao, Shengnan Zhang, Chunyu Zhao, Cong Liu, Dan Li, Yeh Jun Lim, Zhijun Liu, Yan-Mei Li, Yu Qing Liu, Yasuyoshi Kimura, Guoqin Feng, Ted M. Dawson, Enquan Xu, Lin Jiang, Chunyu Jia, Valina L. Dawson, Zhenying Liu, Renxiao Wang, Jin Jian Hu
Publikováno v:
Proc Natl Acad Sci U S A
The spread of pathological α-synuclein (α-syn) is a crucial event in the progression of Parkinson's disease (PD). Cell surface receptors such as lymphocyte activation gene 3 (LAG3) and amyloid precursor-like protein 1 (APLP1) can preferentially bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46975d21336776f6dcf368202d4145bc
https://pubmed.ncbi.nlm.nih.gov/34172566
https://pubmed.ncbi.nlm.nih.gov/34172566
Publikováno v:
ChemNanoMat. 5:606-611
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd109bbc21001e3813fa4bdc96f7e268
https://doi.org/10.1002/cnma.201900007
https://doi.org/10.1002/cnma.201900007
Publikováno v:
Chemical communications (Cambridge, England). 56(83)
We developed a late-stage modification strategy by a phospha-Michael addition reaction between various functional phosphines and unprotected dehydroalanine (Dha) peptides and proteins under mild conditions. This strategy was applied to generate a sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87388efb17429df48f9ca37e8790950
https://pubmed.ncbi.nlm.nih.gov/32960198
https://pubmed.ncbi.nlm.nih.gov/32960198
Autor:
Dan Li, Yeh-Jun Lim, Yan-Mei Li, Houfang Long, Zhenying Liu, Jin-Jian Hu, Cong Liu, Youqi Tao, Xing Zhang, Chunyu Zhao, Yunpeng Sun, Kun Zhao
Publikováno v:
Proc Natl Acad Sci U S A
Post-translational modifications (PTMs) of α-synuclein (α-syn), e.g. phosphorylation, play an important role in modulating α-syn pathology in Parkinson’s disease (PD) and α-synucleinopathies. Accumulation of phosphorylated α-syn fibrils in Lew
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b289922fbca12b08c4278f472bf0f49
Autor:
Ashim Paul, Yang Li, Wuyue Yang, Yeh-Jun Lim, Wen-Hao Li, Daniel L. Segal, Liu Hong, Yan-Mei Li, Gao Li, Yun-Yi Luo
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 26(16)
It has been reported that many molecules could inhibit the aggregation of Aβ (amyloid-β) through suppressing either primary nucleation, secondary nucleation, or elongation processes. In order to suppress multiple pathways of Aβ aggregation, we scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000a3793e2f97942f0fafa8c66ea9b49
https://pubmed.ncbi.nlm.nih.gov/32011042
https://pubmed.ncbi.nlm.nih.gov/32011042
Autor:
Yeh-Jun Lim, Xi-Fei Yang, Tian Qiu, Na Gao, Meng-Rong Ma, Ting-Ting Chu, Yan-Mei Li, Zhi-Wen Hu, Qian-Qian Li, Yufen Zhao, Yong-Xiang Chen
Publikováno v:
RSC Advances. 7:40362-40366
Tau reduction is a favorable strategy for Alzheimer's disease (AD) treatment. In this work, we designed and synthesized a hydrophobic tag conjugated peptide (HyT-Tau-CPP) to selectively promote the degradation of Tau. HyT-Tau-CPP could potently lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::597e59a88aff755d35e68b4ef7024e73
https://doi.org/10.1039/c7ra05347a
https://doi.org/10.1039/c7ra05347a
Autor:
Shengnan Zhang, Yu-Qing Liu, Chunyu Jia, Yeh-Jun Lim, Guoqin Feng, Enquan Xu, Houfang Long, Yasuyoshi Kimura, Youqi Tao, Chunyu Zhao, Chuchu Wang, Zhenying Liu, Jin-Jian Hu, Meng-Rong Ma, Zhijun Liu, Lin Jiang, Dan Li, Renxiao Wang, Dawson, Valina L., Dawson, Ted M.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/29/2021, Vol. 118 Issue 26, p1-12, 12p
Autor:
Kun Zhao, Yeh-Jun Lim, Zhenying Liu, Houfang Long, Yunpeng Sun, Jin-Jian Hu, Chunyu Zhao, Youqi Tao, Xing Zhang, Dan Li, Yan-Mei Li, Cong Liu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/18/2020, Vol. 117 Issue 33, p20305-20315, 11p