Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Yefei Wen"'
Autor:
Guohua Zhang, Zhelong Liu, Hui Ding, Yong Zhou, Hoang Anh Doan, Ka Wai Thomas Sin, Zhiren J. Zhu, Rene Flores, Yefei Wen, Xing Gong, Qingyun Liu, Yi-Ping Li
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor inducti
Externí odkaz:
https://doaj.org/article/e1eba5b33bfe496a995e5d12f008fd11
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 8, Pp 997-1004 (2014)
Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adulthood. Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles.
Externí odkaz:
https://doaj.org/article/4f7fee7af8f342bdb8449583b060ded1
Autor:
Pengpeng Bi, Feng Yue, Yusuke Sato, Sara Wirbisky, Weiyi Liu, Tizhong Shan, Yefei Wen, Daoguo Zhou, Jennifer Freeman, Shihuan Kuang
Publikováno v:
eLife, Vol 5 (2016)
Skeletal myogenesis involves sequential activation, proliferation, self-renewal/differentiation and fusion of myogenic stem cells (satellite cells). Notch signaling is known to be essential for the maintenance of satellite cells, but its function in
Externí odkaz:
https://doaj.org/article/3e630ef48aa24b87a28ae653657ca8a4
Autor:
Dongjiao Zhao, Amber Pond, Bruce Watkins, Dave Gerrard, Yefei Wen, Shihuan Kuang, Kevin Hannon
Publikováno v:
European Journal of Translational Myology, Vol 20, Iss 4, Pp 167-180 (2010)
As a principal tissue responsible for insulin-mediated glucose uptake, skeletal muscle is important for whole-body health. The role of peripheral endocannabinoids as regulators of skeletal muscle metabolism has recently gained a lot of interest, as e
Externí odkaz:
https://doaj.org/article/599d804638164047b5bc7588a751bf0f
Autor:
Sarah Nicklas, Anthony Otto, Xiaoli Wu, Pamela Miller, Sandra Stelzer, Yefei Wen, Shihuan Kuang, Klaus Wrogemann, Ketan Patel, Hao Ding, Jens C Schwamborn
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30445 (2012)
Limb girdle muscular dystrophy type 2H (LGMD2H) is an inherited autosomal recessive disease of skeletal muscle caused by a mutation in the TRIM32 gene. Currently its pathogenesis is entirely unclear. Typically the regeneration process of adult skelet
Externí odkaz:
https://doaj.org/article/589f31e11e654c94a777e1ca3b29ba5b
Autor:
Jolena N Waddell, Peijing Zhang, Yefei Wen, Sanjay K Gupta, Aleksey Yevtodiyenko, Jennifer V Schmidt, Christopher A Bidwell, Ashok Kumar, Shihuan Kuang
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15055 (2010)
Delta-like 1homolog (Dlk1) is an imprinted gene encoding a transmembrane protein whose increased expression has been associated with muscle hypertrophy in animal models. However, the mechanisms by which Dlk1 regulates skeletal muscle plasticity remai
Externí odkaz:
https://doaj.org/article/aa0cdc7fe65544d0bb7e67c03791d396
Autor:
Kyle R. Bohnert, Raksha Bhat, Arshiya Parveen, Yefei Wen, Meiricris Tomaz da Silva, Anirban Roy, Ashok Kumar
Publikováno v:
FASEB J
Skeletal muscle atrophy is a debilitating complication of many chronic disease states and disuse conditions including denervation. However, molecular and signaling mechanisms of muscle wasting remain less understood. Here, we demonstrate that the lev
Autor:
Fengju Chen, Qianxing Mo, Yongcheng Song, Yefei Wen, Guohui Wang, Lianghao Lu, Jingyu Wu, Fangrui Wu, Yuan Yao, Michele S. Redell, Padmini Narayanan
Publikováno v:
Theranostics
Acute myeloid leukemia (AML) is a major blood cancer with poor prognosis. New therapies are needed to target oncogene-driven leukemia stem cells, which account for relapse and resistance. Chromosome translocation t(8;21), which produces RUNX1-ETO (R-
Autor:
Yi-Ping Li, Yong Zhou, Hui Ding, Zhiren J. Zhu, Zhelong Liu, Qingyun Liu, Hoang Anh Doan, René Pedroza Flores, Xing Gong, Guohua Zhang, Yefei Wen, Ka Wai Thomas Sin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Cachexia, characterized by muscle wasting, is a major contributor to cancer-related mortality. However, the key cachexins that mediate cancer-induced muscle wasting remain elusive. Here, we show that tumor-released extracellular Hsp70 and Hsp90 are r
Publikováno v:
Mol Ther
Duchenne muscular dystrophy (DMD) is caused by a mutation of the muscle membrane protein dystrophin and characterized by severe degeneration of myofibers, progressive muscle wasting, loss of mobility, and, ultimately, cardiorespiratory failure and pr