Zobrazeno 1 - 10 of 56 pro vyhledávání: '"Yeesim Khew‐Goodall"'
1
Akademický článek
The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
Autor: Jantina A. Manning, Sonia S. Shah, Andrej Nikolic, Tanya L. Henshall, Yeesim Khew-Goodall, Sharad Kumar
Publikováno v: Cell Death and Disease, Vol 12, Iss 4, Pp 1-16 (2021)
Abstract Kidney disease progression can be affected by Na+ abundance. A key regulator of Na+ homeostasis is the ubiquitin ligase NEDD4-2 and its deficiency leads to increased Na+ transport activity and salt-sensitive progressive kidney damage. Howeve
Externí odkaz: https://doaj.org/article/db675f28146f435585a14a363fb086b9
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2
Akademický článek
Quantifying EGFR endosomal recycling via immunofluorescence in breast cancer cells
Autor: Ana Lonic, Winona Onglao, Yeesim Khew-Goodall
Publikováno v: STAR Protocols, Vol 3, Iss 2, Pp 101305- (2022)
Summary: Previously published protocols for quantification of endosomal recycling are limited by the use of radioactive reagents, washing of cells in reducing buffers, or the requirement for large numbers of cells. Here, we describe a protocol for qu
Externí odkaz: https://doaj.org/article/f6f48a83f2bd469080225f56f8808300
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3
Akademický článek
Down-Regulation of the miRNA-200 Family at the Invasive Front of Colorectal Cancers with Degraded Basement Membrane Indicates EMT Is Involved in Cancer Progression
Autor: Emily L. Paterson, Jan Kazenwadel, Andrew G. Bert, Yeesim Khew-Goodall, Andrew Ruszkiewicz, Gregory J. Goodall
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 2, Pp 180-191 (2013)
Cancer progression is a complex series of events thought to incorporate the reversible developmental process of epithelial-to-mesenchymal transition (EMT). In vitro, the microRNA-200 family maintains the epithelial phenotype by posttranscriptionally
Externí odkaz: https://doaj.org/article/a8b063cc0efe48c5b50992191e57dcb2
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5
Akademický článek
Identification of an enhancer that increases miR-200b~200a~429 gene expression in breast cancer cells.
Autor: Joanne L Attema, Andrew G Bert, Yat-Yuen Lim, Natasha Kolesnikoff, David M Lawrence, Katherine A Pillman, Eric Smith, Paul A Drew, Yeesim Khew-Goodall, Frances Shannon, Gregory J Goodall
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75517 (2013)
The miR-200b~200a~429 gene cluster is a key regulator of EMT and cancer metastasis, however the transcription-based mechanisms controlling its expression during this process are not well understood. We have analyzed the miR-200b~200a~429 locus for ep
Externí odkaz: https://doaj.org/article/a59b1b8a8d0d4780929167d1d70fe099
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6
Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling
Autor: Leila Belle, Gregory J. Goodall, Xiaochun Li, Nicole L. Schieber, Elizabeth V. Nguyen, Freya Gehling, Ana Lonic, Yeesim Khew-Goodall, Roger J. Daly, Robert G. Parton
Publikováno v: The Journal of Cell Biology
Lonic et al. show that phosphorylation of Y374-PKCδ by FER arrests the maturation of early to late endosomes by inhibiting the release of RAB5 from nascent late endosomes. This promotes EGFR recycling and sustained signaling in triple-negative breas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3921a5258e15c853b447ad44aad013a
https://doi.org/10.1083/jcb.201902073
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7
The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
Autor: Sonia S. Shah, Jantina A. Manning, Sharad Kumar, Andrej Nikolic, Yeesim Khew-Goodall, Tanya L Henshall
Publikováno v: Cell Death and Disease, Vol 12, Iss 4, Pp 1-16 (2021)
Cell Death & Disease
Kidney disease progression can be affected by Na+ abundance. A key regulator of Na+ homeostasis is the ubiquitin ligase NEDD4-2 and its deficiency leads to increased Na+ transport activity and salt-sensitive progressive kidney damage. However, the me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f4c65f3d20071f40dbe7fa8ab7204d
https://hdl.handle.net/11541.2/147167
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8
Guidelines and definitions for research on epithelial–mesenchymal transition
Autor: Kyra Campbell, Ruby Yun-Ju Huang, Binhua P. Zhou, Yoshiko Takahashi, Yibin Kang, Cédric Blanpain, Antonio García de Herreros, Ben Z. Stanger, Amparo Cano, Gerhard Christofori, Jordi Casanova, Jean Paul Thiery, Jing Yang, Chaya Kalcheim, Geert Berx, Raghu Kalluri, Sendurai A. Mani, Marc P. Stemmler, Yeesim Khew-Goodall, Marianne E. Bronner, Thomas Brabletz, Heide L. Ford, Masatoshi Takeichi, Jonas Fuxe, Rik Derynck, Anna-Katerina Hadjantonakis, Shoukat Dedhar, Parker B. Antin, M. Angela Nieto, Donald F. Newgreen, Herbert Levine, Raymond B. Runyan, Guojun Sheng, Robert A. Weinberg, Gregory J. Goodall, Keith E. Mostov, Erik W. Thompson, Roberto Mayor, Eric Theveneau, Pierre Savagner, Alain Puisieux, Jinsong Liu, Joan Massagué, Elizabeth D. Williams, Gregory D. Longmore, Jianhua Xing, David R. McClay
Publikováno v: Nature reviews. Molecular cell biology, 21 (6
Nature Reviews. Molecular Cell Biology
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
NATURE REVIEWS MOLECULAR CELL BIOLOGY
On behalf of the EMT International Association (TEMTIA).
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migratio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d459f964c39138d9c74c1f6c5322d660
https://resolver.caltech.edu/CaltechAUTHORS:20200420-125839736
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9
Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration
Autor: Sela T. Po'uha, Miriam Brandl, Andrew J. Gifford, Marion Le Grand, Maria Kavallaris, Gregory J. Goodall, Yeesim Khew-Goodall
Publikováno v: British Journal of Cancer
BackgroundStathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin’s role on the metastatic process, we performed integrated mRNA–miRNA expression analysis to identify pathways regulated by stathmin.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1803814c7bf779d10e914779d5c61f2
https://hdl.handle.net/11541.2/140759
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10
Aberrant post‐translational modifications in endosomal trafficking are potential therapeutic targets to avert therapy resistance in solid cancers
Autor: Winona Onglao, Yeesim Khew‐Goodall, Leila Belle, Ana Lonic
Publikováno v: BioEssays. 44:2100192
Drugs targeting a single TK/RTK in the treatment of solid cancers has not had the same success seen in blood cancers. This is, in part, due to acquired resistance in solid cancers arising from a range of mechanisms including the upregulation of compe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c60735875831eaea67b9e347fa8917
https://doi.org/10.1002/bies.202100192
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