Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yee-Jiun Kok"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101278- (2024)
The gene therapy field seeks cost-effective, large-scale production of recombinant adeno-associated virus (rAAV) vectors for high-dosage therapeutic applications. Although strategies like suspension cell culture and transfection optimization have sho
Externí odkaz:
https://doaj.org/article/5a654ce809564105a4daed88586168a5
Autor:
Karthik P Jayapal, Robin J Philp, Yee-Jiun Kok, Miranda G S Yap, David H Sherman, Timothy J Griffin, Wei-Shou Hu
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2097 (2008)
Many biological processes are intrinsically dynamic, incurring profound changes at both molecular and physiological levels. Systems analyses of such processes incorporating large-scale transcriptome or proteome profiling can be quite revealing. Altho
Externí odkaz:
https://doaj.org/article/5d4113e693204e94849d8627a390f754
Autor:
Nattha Ingavat, Xinhui Wang, Jia Min Liew, Farouq Bin Mahfut, Ka Pui But, Yee Jiun Kok, Xuezhi Bi, Yuansheng Yang, Kobayashi Shintaro, Maria Tsoumpra, Wei Zhang
Publikováno v:
Bioresources and Bioprocessing, Vol 10, Iss 1, Pp 1-19 (2023)
Abstract Bispecific antibody (bsAb), a novel therapeutic modality, provides excellent treatment efficacy, yet poses numerous challenges to downstream process development, which are mainly due to the intricate diversity of bsAb structures and impurity
Externí odkaz:
https://doaj.org/article/96dbc1a052544e37b8c497d86736bb07
Autor:
Guisheng Zeng, Xiaoli Xu, Yee Jiun Kok, Fu-Sheng Deng, Eve Wai Ling Chow, Jiaxin Gao, Xuezhi Bi, Yue Wang
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113473- (2023)
Summary: In the human fungal pathogen Candida albicans, invasive hyphal growth is a well-recognized virulence trait. We employed transposon-mediated genome-wide mutagenesis, revealing that inactivating CTM1 blocks hyphal growth. CTM1 encodes a lysine
Externí odkaz:
https://doaj.org/article/503b43beb442446baffb13dd95de1716
Autor:
Christophe Lay, Collins Wenhan Chu, Rikky Wenang Purbojati, Enzo Acerbi, Daniela I. Drautz-Moses, Paola Florez de Sessions, Song Jie, Eliza Ho, Yee Jiun Kok, Xuezhi Bi, Shuwen Chen, Shi Ya Mak, Mei Chien Chua, Anne E. N. Goh, Wen Chin Chiang, Rajeshwar Rao, Surasith Chaithongwongwatthana, Nipon Khemapech, Voranush Chongsrisawat, Rocio Martin, the JULIUS Study Group, Guus Roeselers, Ying Swan Ho, Martin L. Hibberd, Stephan C. Schuster, Jan Knol
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background The compromised gut microbiome that results from C-section birth has been hypothesized as a risk factor for the development of non-communicable diseases (NCD). In a double-blind randomized controlled study, 153 infants born by ele
Externí odkaz:
https://doaj.org/article/20d67d99e43d4cf8b458365047347bde
Autor:
Amrita M. Nargund, Chang Xu, Amit Mandoli, Atsushi Okabe, Gao Bin Chen, Kie Kyon Huang, Taotao Sheng, Xiaosai Yao, Jia Ming Nickolas Teo, Raghav Sundar, Yee Jiun Kok, Yi Xiang See, Manjie Xing, Zhimei Li, Chern Han Yong, Aparna Anand, Zul Fazreen Bin Adam Isa, Lai Fong Poon, Michelle Shu Wen Ng, Javier Yu Peng Koh, Wen Fong Ooi, Su Ting Tay, Xuewen Ong, Angie Lay Keng Tan, Duane T. Smoot, Hassan Ashktorab, Heike I. Grabsch, Melissa J. Fullwood, Bin Tean Teh, Xuezhi Bi, Atsushi Kaneda, Shang Li, Patrick Tan
Publikováno v:
Cancer Research, 82(14), 2538-2551. American Association for Cancer Research Inc.
Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) in multiple cancers. Here, we discovered that besides its well-established role in DNA repair, MSH2 exerts a novel epigenomic function in gastric cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61c53230d73fbce325f23134840d4a1
https://doi.org/10.1158/0008-5472.can-21-2072
https://doi.org/10.1158/0008-5472.can-21-2072
Autor:
Amrita M. Nargund, Chang Xu, Amit Mandoli, Atsushi Okabe, Gao Bin Chen, Kie Kyon Huang, Taotao Sheng, Xiaosai Yao, Jia Ming Nickolas Teo, Raghav Sundar, Yee Jiun Kok, Yi Xiang See, Manjie Xing, Zhimei Li, Chern Han Yong, Aparna Anand, Zul Fazreen Bin Adam Isa, Lai Fong Poon, Michelle Shu Wen Ng, Javier Yu Peng Koh, Wen Fong Ooi, Su Ting Tay, Xuewen Ong, Angie Lay Keng Tan, Duane T. Smoot, Hassan Ashktorab, Heike I. Grabsch, Melissa J. Fullwood, Bin Tean Teh, Xuezhi Bi, Atsushi Kaneda, Shang Li, Patrick Tan
Publikováno v:
Cancer Research. 83:804-804
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96ca6c1eafba440e7bc11fc78ede8225
https://doi.org/10.1158/0008-5472.can-22-4060
https://doi.org/10.1158/0008-5472.can-22-4060
Autor:
Seow Theng, Ong, Aik Seng, Ng, Xuan Rui, Ng, Zhong, Zhuang, Brandon Han Siang, Wong, Praseetha, Prasannan, Yee Jiun, Kok, Xuezhi, Bi, Heesung, Shim, Heike, Wulff, Kanianthara George, Chandy, Navin Kumar, Verma
Publikováno v:
Bioelectricity
Background: Dying tumor cells release intracellular potassium (K(+)), raising extracellular K(+) ([K(+)](e)) in the tumor microenvironment (TME) to 40–50 mM (high-[K(+)](e)). Here, we investigated the effect of high-[K(+)](e) on T cell functions. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa748ebc4ce42764e4ed5767f773116c
https://pubmed.ncbi.nlm.nih.gov/34471819
https://pubmed.ncbi.nlm.nih.gov/34471819
Autor:
Kanianthara George Chandy, Seow Theng Ong, Aik Seng Ng, Brandon Han Siang Wong, Xuan Rui Ng, Xuezhi Bi, Yee Jiun Kok, Praseetha Prasannan, Heike Wulff, Navin Kumar Verma, Zhong Zhuang, Heesung Shim
Publikováno v:
Bioelectricity, vol 1, iss 3
Background:Dying tumor cells release intracellular potassium (K+), raising extracellular K+([K+]e) in the tumor microenvironment (TME) to 40–50 mM (high-[K+]e). Here, we investigated the effect of high-[K+]eon T cell functions. Materials and Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4653b57f0d05a43e5d1723816a9f3dee
https://doi.org/10.1089/bioe.2019.0016
https://doi.org/10.1089/bioe.2019.0016
Autor:
Wen Qin Tang, Peiqing Zhang, Jong Kwang Hong, Gavin Teo, Dong-Yup Lee, Hsueh Lee Lim, Sarantos Kyriakopoulos, Ying Swan Ho, Yee Jiun Kok, Xuezhi Bi, Meiyappan Lakshmanan, Andy Hee-Meng Tan, Say Kong Ng, Alison P. Lee, Swan Li Poh
Publikováno v:
Biotechnology and Bioengineering. 116:2117-2129
Chinese hamster ovary (CHO) cells are the most prevalent mammalian cell factories for producing recombinant therapeutic proteins due to their ability to synthesize human-like post-translational modifications and ease of maintenance in suspension cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5da9f94cc731ff3aa42efc4dc9bc72
https://doi.org/10.1002/bit.27014
https://doi.org/10.1002/bit.27014