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Akademický článek

Autor: Diane Heiser, Yee Sun Tan, Ian Kaplan, Brian Godsey, Sebastien Morisot, Wen-Chih Cheng, Donald Small, Curt I Civin

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94852 (2014)

Several individual miRNAs (miRs) have been implicated as potent regulators of important processes during normal and malignant hematopoiesis. In addition, many miRs have been shown to fine-tune intricate molecular networks, in concert with other regul

Externí odkaz: https://doaj.org/article/cb4ad8e0511844de965f972ffeab9773

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Akademický článek

Regulation of RAB5C is important for the growth inhibitory effects of MiR-509 in human precursor-B acute lymphoblastic leukemia.

Autor: Yee Sun Tan, MinJung Kim, Tami J Kingsbury, Curt I Civin, Wen-Chih Cheng

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111777 (2014)

MicroRNAs (miRs) regulate essentially all cellular processes, but few miRs are known to inhibit growth of precursor-B acute lymphoblastic leukemias (B-ALLs). We identified miR-509 via a human genome-wide gain-of-function screen for miRs that inhibit

Externí odkaz: https://doaj.org/article/f53751737c1c45509d327154c3e3833e

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Akademický článek

Mediator acts upstream of the transcriptional activator Gal4.

Autor: Keven Ang, Gary Ee, Edwin Ang, Elvin Koh, Wee Leng Siew, Yu Mun Chan, Sabrina Nur, Yee Sun Tan, Norbert Lehming

Publikováno v: PLoS Biology, Vol 10, Iss 3, p e1001290 (2012)

The proteasome inhibitor MG132 had been shown to prevent galactose induction of the S. cerevisiae GAL1 gene, demonstrating that ubiquitin proteasome-dependent degradation of transcription factors plays an important role in the regulation of gene expr

Externí odkaz: https://doaj.org/article/cafe460f9dc342aaa2cbdc68a7aceb0e

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Abstract 2874: Resolving an immune tolerogenic niche at the earliest phase of oral cancer initiation

Autor: Hulya F. Taner, Wong Gong, Luke Broses, Wanqing Chen, Jung Kuczura, Sashider Rajesh, Yee Sun Tan, Yuying Xie, Yu Leo Lei

Publikováno v: Cancer Research. 83:2874-2874

Head and neck squamous cell carcinoma (HNSCC) are immunosuppressed solid tumors often diagnosed at advanced stages of the disease. Most HNSCC patients have a history of oral epithelial dysplasia; however, there are limited diagnostic criteria used to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::148968b70529226fe9f2bb721259454e
https://doi.org/10.1158/1538-7445.am2023-2874

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HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING

Publikováno v: J Clin Invest

The incidence of human papillomavirus–positive (HPV(+)) head and neck squamous cell carcinoma (HNSCC) has surpassed that of cervical cancer and is projected to increase rapidly until 2060. The coevolution of HPV with transforming epithelial cells l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c261e1b7eff7b8eeea6b3f9144b38d
https://www.ncbi.nlm.nih.gov/pubmed/31874109

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Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine

Autor: Christopher R. Donnelly, Yee Sun Tan, Yu Lei, Blake R. Heath, Duxin Sun, Yuying Xie, Xiaobo Luo, Qianming Chen, Kanokwan Sansanaphongpricha, Hongxiang Hu, Emily Bellile, Xinyi Zhao, Robert L. Ferris, Simon Young, Hongwei Chen, Peter J. Polverini, Thomas E. Carey, Gregory T. Wolf, Jacques E. Nör

Publikováno v: Clinical Cancer Research. 24:4242-4255

Purpose: The response rates of Head and Neck Squamous Cell Carcinoma (HNSCC) to checkpoint blockade are below 20%. We aim to develop a mechanism-based vaccine to prevent HNSCC immune escape. Experimental Design: We performed RNA-Seq of sensitive and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ef534ab755bbebe4f931e55c56bf8c
https://doi.org/10.1158/1078-0432.ccr-17-2807

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