Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Yee Siew, Choong"'
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1255 (2024)
The rising levels of type 2 diabetes mellitus (T2DM) and the poor medical effects of the commercially available antidiabetic drugs necessitate the development of potent analogs to treat this multifactorial metabolic disorder. It has been demonstrated
Externí odkaz:
https://doaj.org/article/34b67d9e48384cc3b1f298a890a1ef56
Autor:
Mohammed Alassiri, Jing Yi Lai, Angela Chiew Wen Ch’ng, Yee Siew Choong, Asma Alanazi, Theam Soon Lim
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Antibody phage display is a key tool for the development of monoclonal antibodies against various targets. However, the development of anti-peptide antibodies is a challenging process due to the small size of peptides for binding. This makes
Externí odkaz:
https://doaj.org/article/8d301c1d7bf04cae9fd90d18eeec34cb
Autor:
Anizah Rahumatullah, Dinesh Balachandra, Rahmah Noordin, Zamrina Baharudeen, Yee Ying Lim, Yee Siew Choong, Theam Soon Lim
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Antibodies have different chemical properties capable of targeting a diverse nature of antigens. Traditionally, immune antibody libraries are perceived to be disease-specific with a skewed repertoire. The complexity during the generation of
Externí odkaz:
https://doaj.org/article/fee29d8c22f84d63ba6aa14747bdfd8c
Autor:
Jackson K. Nkoana, Marole M. Maluleka, Malose J. Mphahlele, Richard M. Mampa, Yee Siew Choong
Publikováno v:
Molecules, Vol 27, Iss 20, p 6935 (2022)
The ambident electrophilic character of the 5-bromo-2-hydroxychalcones and the binucleophilic nature of 2-aminothiophenol were exploited to construct the 2-aryl-4-(4-bromo-2-hydroxyphenyl)benzo[1,5]thiazepines. The structures and conformation of thes
Externí odkaz:
https://doaj.org/article/a2e6b44a2a0c469eaa74cc93dc520df0
Autor:
Frank Camacho, Ernesto Moreno, Luis F. Garcia-Alles, Glay Chinea Santiago, Martine Gilleron, Aleikar Vasquez, Yee Siew Choong, Fátima Reyes, Mohd Nor Norazmi, Maria E. Sarmiento, Armando Acosta
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Lipids, glycolipids and lipopeptides derived from Mycobacterium tuberculosis (Mtb) are presented to T cells by monomorphic molecules known as CD1. This is the case of the Mtb-specific sulfoglycolipid Ac2SGL, which is presented by CD1b molecules and i
Externí odkaz:
https://doaj.org/article/f3f3bd582e4748838f211d7ae30b0594
Publikováno v:
BioTechniques, Vol 65, Iss 5, Pp 269-274 (2018)
Gene assembly methods are an integral part of molecular cloning experiments. The majority of existing vector assembly methods stipulate a need for exonucleases, endonucleases and/or the use of single-stranded DNA as starting materials. Here, we intro
Externí odkaz:
https://doaj.org/article/969193da52524b2d835d6ff5a192606f
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1516-1528 (2018)
A series of 2-arylbenzo[b]furan–appended 4-aminoquinazoline hybrids were prepared and evaluated for cytotoxicity in vitro against the human lung cancer (A549), colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A) and cervical cancer (
Externí odkaz:
https://doaj.org/article/3e7d4bce138141f6b0604661811a732a
Autor:
Chai Fung Chin, Jing Yi Lai, Yee Siew Choong, Amy Amilda Anthony, Asma Ismail, Theam Soon Lim
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Hemolysin E (HlyE) is an immunogenic novel pore-forming toxin involved in the pathogenesis of typhoid fever. Thus, mapping of B-cell epitopes of Salmonella enterica serovar Typhi (S. Typhi) is critical to identify key immunogenic regions of
Externí odkaz:
https://doaj.org/article/a4d6c9f4fd8d4388a6dd540c4d1fa61a
Autor:
Malose J. Mphahlele, Marole M. Maluleka, Yee Siew Choong, Bernice A. Monchusi, Vusi G. Mbazima
Publikováno v:
Medicinal Chemistry Research. 31:2243-2259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7830857b4b5c8675020cabf856453e39
https://doi.org/10.1007/s00044-022-02980-1
https://doi.org/10.1007/s00044-022-02980-1
Publikováno v:
Molecules, Vol 26, Iss 9, p 2692 (2021)
The 2-amino-5-(3/4-fluorostyryl)acetophenones were prepared and reacted with benzaldehyde derivatives to afford the corresponding 5-styryl-2-aminochalcone hybrids. The trans geometry of the styryl and α,β-unsaturated carbonyl arms, and the presence
Externí odkaz:
https://doaj.org/article/6224b70469e54f938f2b5c07e6d63720