Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Yee Hwa, Wong"'
Autor:
Nikhil Kumar Tulsian, Raghuvamsi Venkata Palur, Xinlei Qian, Yue Gu, Bhuvaneshwari D/O Shunmuganathan, Firdaus Samsudin, Yee Hwa Wong, Jianqing Lin, Kiren Purushotorman, Mary McQueen Kozma, Bei Wang, Julien Lescar, Cheng-I Wang, Ravindra Kumar Gupta, Peter John Bond, Paul Anthony MacAry
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. The functional activity of neutralizing antibodies is linked t
Externí odkaz:
https://doaj.org/article/54f52c1fa0c948c5b812e8554189a002
Publikováno v:
FEBS Open Bio, Vol 13, Iss 6, Pp 1095-1106 (2023)
Peptide asparaginyl ligases (PALs) are precision tools for peptide cyclization, cell‐surface labelling, protein semisynthesis and protein conjugation. PALs are expressed as inactive proenzymes requiring low pH activation. During activation, a large
Externí odkaz:
https://doaj.org/article/5dfed74a53e64c6b9d8ed6c9eaef0452
Autor:
Yue Gu, Robynne W. K. Koh, May Ling Lai, Denise Pochinco, Rachel Z. C. Teo, Marieta Chan, Tanusya M. Murali, Chong Wai Liew, Yee Hwa Wong, Nicholas R. J. Gascoigne, Kathryn J. Wood, Julien Lescar, Peter Nickerson, Paul A. MacAry, Anantharaman Vathsala
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract The current state-of-the-art technology employed to assess anti-human leukocyte antigen antibodies (Anti-HLA Ab) for donor-recipient matching and patient risk stratification in renal transplantation is the single antigen bead (SAB) assay. Ho
Externí odkaz:
https://doaj.org/article/0d892bb6ce394324a9db08fda50ac687
Autor:
Yue Gu, Yee Hwa Wong, Chong Wai Liew, Conrad E. Z. Chan, Tanusya M. Murali, Jiawei Yap, Chien Tei Too, Kiren Purushotorman, Maryam Hamidinia, Abbas El Sahili, Angeline T. H. Goh, Rachel Z. C. Teo, Kathryn J. Wood, Brendon J. Hanson, Nicholas R. J. Gascoigne, Julien Lescar, Anantharaman Vathsala, Paul A. MacAry
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA f
Externí odkaz:
https://doaj.org/article/d43685122a4b496da7e60656bb9c199a
Autor:
Nikhil Tulsian, Palur Raghuvamsi, Xinlei Qian, Yue Gu, Bhuvaneshwari D/O Shunmuganathan, Firdaus Samsudin, Yee Hwa Wong, Jianqing Lin, Kiren Purushotorman, Mary Kozma, BEI WANG, Julien Lescar, Cheng-I Wang, Ravindra Gupta, Peter Bond, Paul MacAry
The changing landscape of mutations in the SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. A major factor that contributes to the functional acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2e04aa582f3a355e27b325f33512af
https://doi.org/10.21203/rs.3.rs-2465199/v1
https://doi.org/10.21203/rs.3.rs-2465199/v1
Autor:
Side Hu, Abbas El Sahili, Srujana Kishore, Yee Hwa Wong, Xinya Hemu, Boon Chong Goh, Zhen Wang, James P. Tam, Chuan-Fa Liu, Julien Lescar
Peptide asparaginyl ligases (PALs) belong to a limited class of enzymes from cyclotide-producing plants, that perform site-specific ligation reactions after a target peptide Asx (Asn/Asp) binds to the ligase active site. How PALs specifically recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9497a83c45f22f4c44aba37bdcec95ac
https://doi.org/10.1101/2021.12.09.471967
https://doi.org/10.1101/2021.12.09.471967
Autor:
Side Hu, Abbas El Sahili, Srujana Kishore, Yee Hwa Wong, Xinya Hemu, Boon Chong Goh, Sang Zhipei, Zhen Wang, James P Tam, Chuan-Fa Liu, Julien Lescar
Publikováno v:
The Plant cell. 34(12)
Peptide ligases are versatile enzymes that can be utilized for precise protein conjugation for bioengineering applications. Hyperactive peptide asparaginyl ligases (PALs), such as butelase-1, belong to a small class of enzymes from cyclotide-producin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485a2dca3cba19b5f6a37021dc97da09
https://pubmed.ncbi.nlm.nih.gov/36099055
https://pubmed.ncbi.nlm.nih.gov/36099055
Autor:
Kalyan Kumar Pasunooti, Pooja Gopal, Shanmugavel Gnanakalai, Nelson B. Olivier, Siau Hoi Lim, Julien Lescar, Seetharamsing Balamkundu, Vinod Gadi, Wenhe Zhong, Peter C. Dedon, Chuan-Fa Liu, Yok Hian Chionh, Ed T. Buurman, Thomas Dick, Megan E. McBee, Qianhui Nah, Yee Hwa Wong
Publikováno v:
Journal of Medicinal Chemistry. 62:7788-7805
Among the >120 modified ribonucleosides in the prokaryotic epitranscriptome, many tRNA modifications are critical to bacterial survival, which makes their synthetic enzymes ideal targets for antibiotic development. Here we performed a structure-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550e33b18ac78640a1f11420a6243e12
https://doi.org/10.1021/acs.jmedchem.9b00582
https://doi.org/10.1021/acs.jmedchem.9b00582
Autor:
Somchart Maenpuen, Narumon Thongdee, Erin G. Prestwich, Skorn Mongkolsuk, Wenhe Zhong, Abbas El Sahili, Sopapan Atichartpongkul, Yok Hian Chionh, Megan E. McBee, Julien Lescar, Chong Wai Liew, Juthamas Jaroensuk, Pimchai Chaiyen, Yee Hwa Wong, Peter C. Dedon, Michael S. DeMott, Mayuree Fuangthong, Qianhui Nah
Publikováno v:
RNA. 25:1481-1496
The tRNA (m1G37) methyltransferase TrmD catalyzes m1G formation at position 37 in many tRNA isoacceptors and is essential in most bacteria, which positions it as a target for antibiotic development. In spite of its crucial role, little is known about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10d0f9510160f0ccf682b4a455242e3b
https://doi.org/10.1261/rna.066746.118
https://doi.org/10.1261/rna.066746.118
Autor:
Julien Lescar, Yee Hwa Wong, Hui Qi Ng, Jeffrey Hill, Ann Zhufang Koay, Peter C. Dedon, CongBao Kang, Wenhe Zhong, Qianhui Nah, Yan Li
Publikováno v:
Josephina Lee
Bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) plays important roles in translation, making it an important target for the development of new antibacterial compounds. TrmD comprises two domains with the N-terminal domain binding to the S-aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897348e9c8823878e68052427c740503
https://doi.org/10.1007/s12104-019-09900-2
https://doi.org/10.1007/s12104-019-09900-2