Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Yee Chan-Li"'
Autor:
Kevin M. Motz, Ioan A. Lina, Idris Samad, Michael K. Murphy, Madhavi Duvvuri, Ruth J. Davis, Alexander Gelbard, Liam Chung, Yee Chan-Li, Samuel Collins, Jonathan D. Powell, Jennifer H. Elisseeff, Maureen R. Horton, Alexander T. Hillel
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Laryngotracheal stenosis (LTS) is pathologic fibrotic narrowing of the larynx and trachea characterized by hypermetabolic fibroblasts and CD4+ T cell–mediated inflammation. However, the role of CD4+ T cells in promoting LTS fibrosis is unknown. The
Externí odkaz:
https://doaj.org/article/89ce5a887c6b4f738d6058bd9b2c232a
Autor:
Min-Hee Oh, Samuel L. Collins, Im-Hong Sun, Ada J. Tam, Chirag H. Patel, Matthew L. Arwood, Yee Chan-Li, Jonathan D. Powell, Maureen R. Horton
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2439-2454 (2017)
Tissue-resident macrophages play critical roles in sentinel and homeostatic functions as well as in promoting inflammation and immunity. It has become clear that the generation of these cells is highly dependent upon tissue-specific cues derived from
Externí odkaz:
https://doaj.org/article/b5d0f411c85b40db86bd56b80a8b57bf
Autor:
Christine L Vigeland, Samuel L Collins, Yee Chan-Li, Andrew H Hughes, Min-Hee Oh, Jonathan D Powell, Maureen R Horton
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163288 (2016)
Pulmonary fibrosis is a devastating, incurable disease in which chronic inflammation and dysregulated, excessive wound healing lead to progressive fibrosis, lung dysfunction, and ultimately death. Prior studies have implicated the cytokine IL-17A and
Externí odkaz:
https://doaj.org/article/ba285b184aa34eeeb91fa60134a0fa9a
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31299 (2012)
Pulmonary fibrosis is an untreatable, uniformly fatal disease of unclear etiology that is the result of unremitting chronic inflammation. Recent studies have implicated bone marrow derived fibrocytes and M2 macrophages as playing key roles in propaga
Externí odkaz:
https://doaj.org/article/577ea467bc9c4a77b97e1b2aeb2f5104
Akademický článek
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Autor:
Kevin M. Motz, Ioan A. Lina, Idris Samad, Michael K. Murphy, Madhavi Duvvuri, Ruth J. Davis, Alexander Gelbard, Liam Chung, Yee Chan-Li, Samuel Collins, Jonathan D. Powell, Jennifer H. Elisseeff, Maureen R. Horton, Alexander T. Hillel
Publikováno v:
JCI Insight.
Autor:
Alexandra J. Berges, Rafael Ospino, Ioan A. Lina, Samuel Collins, Yee Chan‐Li, Alexander Gelbard, Alexander T. Hillel, Kevin M. Motz
Publikováno v:
The Laryngoscope.
Autor:
Rafael Ospino, Alexandra Berges, Laura Mafla, Samuel Collins, Yee Chan Li, Ioan Lina, Alexander Gelbard, Alexander T. Hillel, Kevin Motz
Publikováno v:
The Laryngoscope.
Idiopathic subglottic stenosis (iSGS) is characterized by progressive fibrosis and subglottic luminal narrowing. Currently, immune characterization has focused on T-cells; however, macrophages remain largely unexplored. The goals of this study are to
Autor:
Yee Chan-Li, Liang Zhao, Jonathan D. Powell, Im Hong Sun, Samuel L. Collins, Maureen R. Horton, Min Hee Oh
Publikováno v:
The Journal of Immunology. 207:913-922
Metabolic programming is integrally linked to immune cell function. Nowhere is this clearer than in the differentiation of macrophages. Proinflammatory M1 macrophages primarily use glycolysis as a rapid energy source but also to generate antimicrobia
Autor:
Ada J. Tam, Samuel L. Collins, Rana Rais, Jonathan D. Powell, Richard L. Blosser, Yee Chan-Li, Im Hong Sun, Barbara S. Slusher, Jiayu Wen, Lukáš Tenora, Matthew L. Arwood, Chirag H. Patel, Wei Xu, Maureen R. Horton, Min Hee Oh, Judson Englert, Im Meng Sun, Liang Zhao, Robert Leone, Pavel Majer
Publikováno v:
J Clin Invest
Myeloid cells comprise a major component of the tumor microenvironment (TME) that promotes tumor growth and immune evasion. By employing a small-molecule inhibitor of glutamine metabolism, not only were we able to inhibit tumor growth, but we markedl