Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Yee, SW"'
Autor:
Relling, MV, Krauss, RM, Roden, DM, Klein, TE, Fowler, DM, Terada, N, Lin, L, Riel-Mehan, M, Do, TP, Kubo, M, Yee, SW, Johnson, GT, Giacomini, KM
Publikováno v:
Clinical pharmacology and therapeutics, vol 102, iss 6
The goal of pharmacogenomics research is to discover genetic polymorphisms that underlie variation in drug response. Increasingly, pharmacogenomics research involves large numbers of patients and the application of new technologies and methodologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::efde5210c44066781cc205ccaa4446e2
https://escholarship.org/uc/item/78p807fd
https://escholarship.org/uc/item/78p807fd
Autor:
Liang, X, Chien, HC, Yee, SW, Giacomini, MM, Chen, EC, Piao, M, Hao, J, Twelves, J, Lepist, EI, Ray, AS, Giacomini, KM
Publikováno v:
Molecular pharmaceutics, vol 12, iss 12
Liang, X; Chien, HC; Yee, SW; Giacomini, MM; Chen, EC; Piao, M; et al.(2015). Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Molecular Pharmaceutics, 12(12), 4301-4310. doi: 10.1021/acs.molpharmaceut.5b00501. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4mb4p3rn
Liang, X; Chien, HC; Yee, SW; Giacomini, MM; Chen, EC; Piao, M; et al.(2015). Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Molecular Pharmaceutics, 12(12), 4301-4310. doi: 10.1021/acs.molpharmaceut.5b00501. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4mb4p3rn
© 2015 American Chemical Society. The biguanide metformin is widely used as first-line therapy for the treatment of type 2 diabetes. Predominately a cation at physiological pH's, metformin is transported by membrane transporters, which play major ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::22b0b5c1c7df661c673982c23389a059
https://escholarship.org/uc/item/4mb4p3rn
https://escholarship.org/uc/item/4mb4p3rn
Autor:
Wen, CC, Yee, SW, Liang, X, Hoffmann, TJ, Kvale, MN, Banda, Y, Jorgenson, E, Schaefer, C, Risch, N, Giacomini, KM
Publikováno v:
Clinical pharmacology and therapeutics, vol 97, iss 5
The first-line treatment of hyperuricemia, which causes gout, is allopurinol. The allopurinol response is highly variable, with many users failing to achieve target serum uric acid (SUA) levels. No genome-wide association study (GWAS) has examined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::351f0b2640f5080f6bbededa56c4fcab
https://escholarship.org/uc/item/7r50w6p6
https://escholarship.org/uc/item/7r50w6p6
Autor:
Clancy, JP, Johnson, SG, Yee, SW, McDonagh, EM, Caudle, KE, Klein, TE, Cannavo, M, Giacomini, KM, Clinical Pharmacogenetics Implementation Consortium
Publikováno v:
Clinical pharmacology and therapeutics, vol 95, iss 6
Cystic fibrosis (CF) is a life-shortening disease arising as a consequence of mutations within the CFTR gene. Novel therapeutics for CF are emerging that target CF transmembrane conductance regulator protein (CFTR) defects resulting from specific CFT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::c7753459d75a2b5c18b03ebab1164efe
https://escholarship.org/uc/item/48r4255k
https://escholarship.org/uc/item/48r4255k
Autor:
Goswami, S, Yee, SW, Stocker, S, Mosley, JD, Kubo, M, Castro, R, Mefford, JA, Wen, C, Liang, X, Witte, J, Brett, C, Maeda, S, Simpson, MD, Hedderson, MM, Davis, RL, Roden, DM, Giacomini, KM, Savic, RM
Publikováno v:
Clinical Pharmacology and Therapeutics, vol 96, iss 5
Goswami, S; Yee, SW; Stocker, S; Mosley, JD; Kubo, M; Castro, R; et al.(2014). Erratum: Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin (Clinical Pharmacology and Therapeutics (2014) 96:3 (370-379) DOI:10.1038/clpt.2014.109). Clinical Pharmacology and Therapeutics, 96(5), 626. doi: 10.1038/clpt.2014.109. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/13q3091f
Goswami, S; Yee, SW; Stocker, S; Mosley, JD; Kubo, M; Castro, R; et al.(2014). Erratum: Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin (Clinical Pharmacology and Therapeutics (2014) 96:3 (370-379) DOI:10.1038/clpt.2014.109). Clinical Pharmacology and Therapeutics, 96(5), 626. doi: 10.1038/clpt.2014.109. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/13q3091f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::357863c1f89849ed8325bee73d564d47
https://escholarship.org/uc/item/13q3091f
https://escholarship.org/uc/item/13q3091f
Autor:
Giacomini, Kathleen, Geier, EG, Chen, EC, Webb, A, Papp, AC, Yee, SW, Sadee, W, Giacomini, KM
Publikováno v:
Giacomini, Kathleen; Geier, EG; Chen, EC; Webb, A; Papp, AC; Yee, SW; et al.(2013). Profiling solute carrier transporters in the human blood-brain barrier. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5hz8r4mb
The neuroprotective function of the blood-brain barrier (BBB) presents a major challenge for drug delivery to the central nervous system (CNS). Critical to this function, BBB membrane transporters include the ATP-binding cassette (ABC) transporters,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::52b399f734506395a9b0db3e706bb3ad
http://www.escholarship.org/uc/item/5hz8r4mb
http://www.escholarship.org/uc/item/5hz8r4mb
Publikováno v:
Clinical pharmacology and therapeutics, vol 94, iss 1
The 386 human SLC superfamily members are diverse in sequence, structure, and function. Using sequence similarity, we previously classified the SLC superfamily members and identified relationships among families. With the recent determination of new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::10955e27dd655bcfc3e5b2f79b134505
https://escholarship.org/uc/item/3490105k
https://escholarship.org/uc/item/3490105k
Autor:
Giacomini, Kathleen, Witte, John, Andreadis, Charalambos, Yee, SW, Mefford, JA, Singh, N, Percival, ME, Stecula, A, Yang, K, Witte, JS, Takahashi, A, Kubo, M, Matsuda, K
Publikováno v:
Giacomini, Kathleen; Witte, John; Andreadis, Charalambos; Yee, SW; Mefford, JA; Singh, N; et al.(2013). Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9pj4g64h
Acute myeloid leukemia (AML) is a clinically heterogeneous disease, with a 5-year disease-free survival (DFS) ranging from under 10% to over 70% for distinct groups of patients. At our institution, cytarabine, etoposide and busulfan are used in first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::fe82358d0fe1b517a9ca460ec77e71bb
http://www.escholarship.org/uc/item/9pj4g64h
http://www.escholarship.org/uc/item/9pj4g64h
Autor:
Ferrin, Thomas, Giacomini, Kathleen, Costello, Joseph, Chen, L, Hong, C, Chen, EC, Yee, SW, Xu, L, Almof, EU, Wen, C, Fujii, K, Johns, SJ, Stryke, D
Publikováno v:
Ferrin, Thomas; Giacomini, Kathleen; Costello, Joseph; Chen, L; Hong, C; Chen, EC; et al.(2013). Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4xd571vp
Human organic cation transporter 3 (OCT3 and SLC22A3) mediates the uptake of many important endogenous amines and basic drugs in a variety of tissues. OCT3 is identified as one of the important risk loci for prostate cancer, and is markedly underexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::6d2a2440469d3547aadccb29f80f499a
http://www.escholarship.org/uc/item/4xd571vp
http://www.escholarship.org/uc/item/4xd571vp
Autor:
Giacomini, Kathleen, Kroetz, Deanna, Matsson, P, Yee, SW, Markova, S, Morrissey, K, Jenkins, G, Xuan, J, Jorgenson, E, Kroetz, DL, Giacomini, KM
Publikováno v:
Giacomini, Kathleen; Kroetz, Deanna; Matsson, P; Yee, SW; Markova, S; Morrissey, K; et al.(2012). Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5d475641
ATP-binding cassette (ABC) membrane transporters determine the disposition of many drugs, metabolites and endogenous compounds. Coding region variation in ABC transporters is the cause of many genetic disorders, but much less is known about the genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::0f56c0a958b5ba227f96a4c6ece6691e
http://www.escholarship.org/uc/item/5d475641
http://www.escholarship.org/uc/item/5d475641