Zobrazeno 1 - 10
of 344
pro vyhledávání: '"Yechiel Shai"'
Autor:
Gal Kapach, Reut Nuri, Christiane Schmidt, Adi Danin, Shir Ferrera, Alon Savidor, Roman G. Gerlach, Yechiel Shai
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Bacterial resistance to antibiotics is a major concern worldwide, leading to an extensive search for alternative drugs. Promising candidates are antimicrobial peptides (AMPs), innate immunity molecules, shown to be highly efficient against multidrug
Externí odkaz:
https://doaj.org/article/187d724921b845d7bcf81a479dfc02f5
Publikováno v:
Antibiotics, Vol 10, Iss 1, p 87 (2021)
The outcome of an antibiotic treatment on the growth capacity of bacteria is largely dependent on the initial population size (Inoculum Effect). We characterized and built a model of this effect in E. coli cultures using a large variety of antimicrob
Externí odkaz:
https://doaj.org/article/41acd270724f4b6893cbc243cdde232c
Autor:
Etai Rotem, Omri Faingold, Meital Charni, Yoel A Klug, Daniel Harari, Liraz Shmuel-Galia, Alon Nudelman, Varda Rotter, Yechiel Shai
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007044 (2018)
The ability of the Lentivirus HIV-1 to inhibit T-cell activation by its gp41 fusion protein is well documented, yet limited data exists regarding other viral fusion proteins. HIV-1 utilizes membrane binding region of gp41 to inhibit T-cell receptor (
Externí odkaz:
https://doaj.org/article/b88ed0a2bd3242799fd4a896485b0d41
Autor:
Lea H Eckhard, Yael Houri-Haddad, Asaf Sol, Rotem Zeharia, Yechiel Shai, Shaul Beyth, Abraham J Domb, Gilad Bachrach, Nurit Beyth
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162537 (2016)
The development of antibacterial drugs to overcome various pathogenic species, which inhabit the oral cavity, faces several challenges, such as salivary flow and enzymatic activity that restrict dosage retention. Owing to their amphipathic nature, an
Externí odkaz:
https://doaj.org/article/6eb8444daa6d4260b3c42740f6dc140e
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 11, Pp 8027-8051 (2011)
Cancer continues to be a leading source of morbidity and mortality worldwide in spite of progress in oncolytic therapies. In addition, the incidence of cancers affecting the breast, kidney, prostate and skin among others continue to rise. Chemotherap
Externí odkaz:
https://doaj.org/article/7b0d6ea40f714da28af2fe63b90f6621
Autor:
Eliran Moshe Reuven, Mohammad Ali, Etai Rotem, Roland Schwarzer, Andrea Gramatica, Anthony H Futerman, Yechiel Shai
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004248 (2014)
HIV-1 uses a number of means to manipulate the immune system, to avoid recognition and to highjack signaling pathways. HIV-1 infected cells show limited Toll-Like Receptor (TLR) responsiveness via as yet unknown mechanisms. Using biochemical and biop
Externí odkaz:
https://doaj.org/article/ab38f3fe8b784f4f825c75940f3e4030
Autor:
Lea H Eckhard, Asaf Sol, Ester Abtew, Yechiel Shai, Abraham J Domb, Gilad Bachrach, Nurit Beyth
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109413 (2014)
Antimicrobial peptides (AMPs) are conserved evolutionary components of the innate immune system that are being tested as alternatives to antibiotics. Slow release of AMPs using biodegradable polymers can be advantageous in maintaining high peptide le
Externí odkaz:
https://doaj.org/article/c1ce72f253404bc3a4275c7cfeb3881a
Autor:
Ron Saar Dover, Yechiel Shai
Publikováno v:
Bio-Protocol, Vol 3, Iss 15 (2013)
The molecular mechanism by which peptide antibiotics (also referred as cationic antimicrobial peptides-CAMPs) penetrate through the bacterial wall barrier, interact with, and disrupt their membrane is complex. It depends mainly on the peptide propert
Externí odkaz:
https://doaj.org/article/6c91447399d04a6f8d4a55a9ca5bf023
Autor:
Ron Saar-Dover, Arkadi Bitler, Ravit Nezer, Liraz Shmuel-Galia, Arnaud Firon, Eyal Shimoni, Patrick Trieu-Cuot, Yechiel Shai
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11 (2012)
Externí odkaz:
https://doaj.org/article/1c82a80037234366aa6993c348c8ba31
Autor:
Ron Saar-Dover, Arkadi Bitler, Ravit Nezer, Liraz Shmuel-Galia, Arnaud Firon, Eyal Shimoni, Patrick Trieu-Cuot, Yechiel Shai
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002891 (2012)
Cationic antimicrobial peptides (CAMPs) serve as the first line of defense of the innate immune system against invading microbial pathogens. Gram-positive bacteria can resist CAMPs by modifying their anionic teichoic acids (TAs) with D-alanine, but t
Externí odkaz:
https://doaj.org/article/5761967c6968477fb32bca29c6f6f52b