Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.

Autor: Asarnow D; Department of Biochemistry and Biophysics, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA., Wang B; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Lee WH; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Hu Y; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Huang CW; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Faust B; Department of Biochemistry and Biophysics, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA., Ng PML; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Ngoh EZX; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Bohn M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), San Francisco, CA, USA., Bulkley D; Department of Biochemistry and Biophysics, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA., Pizzorno A; CIRI, Centre International de Recherche en Infectiologie (Team VirPath), Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France., Ary B; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), San Francisco, CA, USA., Tan HC; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Lee CY; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Minhat RA; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Terrier O; CIRI, Centre International de Recherche en Infectiologie (Team VirPath), Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France., Soh MK; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Teo FJ; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Yeap YYC; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Seah SGK; Biological Defence Program, DSO National Laboratories, 27 Medical Drive, Singapore 117510, Singapore., Chan CEZ; Biological Defence Program, DSO National Laboratories, 27 Medical Drive, Singapore 117510, Singapore., Connelly E; Department of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), San Francisco, CA, USA., Young NJ; Department of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), San Francisco, CA, USA., Maurer-Stroh S; Bioinformatics Institute, Agency for Science, Technology and Research (A(∗)STAR), 30 Biopolis Street, Matrix, Singapore 138671, Singapore; Infectious Diseases Laboratories (ID Labs), Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore; Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117558, Singapore., Renia L; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore; Infectious Diseases Laboratories (ID Labs), Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore., Hanson BJ; Biological Defence Program, DSO National Laboratories, 27 Medical Drive, Singapore 117510, Singapore., Rosa-Calatrava M; CIRI, Centre International de Recherche en Infectiologie (Team VirPath), Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France; VirNext, Faculté de Médecine RTH Laennec, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France., Manglik A; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Anesthesia and Perioperative Care, UCSF, San Francisco, CA, USA. Electronic address: aashish.manglik@ucsf.edu., Cheng Y; Department of Biochemistry and Biophysics, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA; Howard Hughes Medical Institute, UCSF, San Francisco, CA, USA. Electronic address: ycheng@ucsf.edu., Craik CS; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), San Francisco, CA, USA. Electronic address: charles.craik@ucsf.edu., Wang CI; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Singapore. Electronic address: wang_chengi@immunol.a-star.edu.sg.

Publikováno v: Cell [Cell] 2021 Jun 10; Vol. 184 (12), pp. 3192-3204.e16. Date of Electronic Publication: 2021 Apr 24.

MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.

Autor: Xu D; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; College of Biological Science and Engineering, Institute of Life Sciences, Fuzhou University, Fuzhou, China., Yao M; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Wang Y; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Yuan L; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China., Hoeck JD; CR-UK London Research Institute, London, United Kingdom., Yu J; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Liu L; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Yeap YYC; School of Biomedical Science, Faculty of Medicine, University of Queensland, St Lucia, Australia., Zhang W; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Zhang F; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Feng Y; Sino-Danish College, University of Chinese Academy of Science, Beijing, China., Ma T; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Wang Y; College of Biological Science and Engineering, Institute of Life Sciences, Fuzhou University, Fuzhou, China., Ng DCH; School of Biomedical Science, Faculty of Medicine, University of Queensland, St Lucia, Australia., Niu X; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Su B; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America., Behrens A; Adult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom.; King's College London, Faculty of Life Sciences and Medicine, Guy's Campus, London, United Kingdom., Xu Z; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.; Sino-Danish College, University of Chinese Academy of Science, Beijing, China.; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing, China.

Publikováno v: PLoS biology [PLoS Biol] 2018 Dec 19; Vol. 16 (12), pp. e2006613. Date of Electronic Publication: 2018 Dec 19 (Print Publication: 2018).