Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Yea-Lih Lin"'
Autor:
Hervé Técher, Diyavarshini Gopaul, Jonathan Heuzé, Nail Bouzalmad, Baptiste Leray, Audrey Vernet, Clément Mettling, Jérôme Moreaux, Philippe Pasero, Yea-Lih Lin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Oncogene-induced senescence (OIS) arrests cell proliferation in response to replication stress (RS) induced by oncogenes. OIS depends on the DNA damage response (DDR), but also on the cGAS-STING pathway, which detects cytosolic DNA and induc
Externí odkaz:
https://doaj.org/article/8201c42fc7e04191864ba9df7a017342
Autor:
Sara Ovejero, Elena Viziteu, Laure Dutrieux, Julie Devin, Yea-Lih Lin, Elina Alaterre, Michel Jourdan, Jihane Basbous, Guilhem Requirand, Nicolas Robert, Hugues de Boussac, Anja Seckinger, Dirk Hose, Laure Vincent, Charles Herbaux, Angelos Constantinou, Philippe Pasero, Jérôme Moreaux
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multiple myeloma (MM) is a hematologic cancer characterized by accumulation of malignant plasma cells in the bone marrow. To date, no definitive cure exists for MM and resistance to current treatments is one of the major challenges of this disease. T
Externí odkaz:
https://doaj.org/article/8605def9a5a94e54ac65b0f7d255bd7b
Autor:
Alexy Promonet, Ismaël Padioleau, Yaqun Liu, Lionel Sanz, Anna Biernacka, Anne-Lyne Schmitz, Magdalena Skrzypczak, Amélie Sarrazin, Clément Mettling, Maga Rowicka, Krzysztof Ginalski, Frédéric Chedin, Chun-Long Chen, Yea-Lih Lin, Philippe Pasero
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
While R-loops can alter cell homeostasis, it is unclear what determines their toxicity. Here, the authors, by using Top1 knockdown as a tool to enhance the formation of R-loops at certain genomic sites, reveal and characterize a proportion of R-loops
Externí odkaz:
https://doaj.org/article/bd1932962b864455ac3b032015f1a0ac
Autor:
Julien N. Bianco, Valérie Bergoglio, Yea-Lih Lin, Marie-Jeanne Pillaire, Anne-Lyne Schmitz, Julia Gilhodes, Amelie Lusque, Julien Mazières, Magali Lacroix-Triki, Theodoros I. Roumeliotis, Jyoti Choudhary, Jérôme Moreaux, Jean-Sébastien Hoffmann, Hélène Tourrière, Philippe Pasero
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Oncogene-induced replication stress (RS) promotes cancer development. Here, the authors report that cancer cells adapt to oncogene-induced RS by overexpressing downstream components of ATR-CHK1 pathway, Claspin and Timeless, which have protective rol
Externí odkaz:
https://doaj.org/article/fdf314771754477295f673e54990011e
Autor:
Nanda Kumar Sasi, Flavie Coquel, Yea-Lih Lin, Jeffrey P MacKeigan, Philippe Pasero, Michael Weinreich
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 10, Pp 985-995 (2018)
Summary: CDC7-DBF4 kinase (DDK) initiates DNA replication in eukaryotes by activating the replicative MCM helicase. DDK has diverse and apparently conflicting roles in the replication checkpoint response in various organisms, but the underlying mecha
Externí odkaz:
https://doaj.org/article/bb1c67a26bea41f6b90ce1548bb39b94
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 1 (2021)
R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops, we mapped RNA:DNA hybrids, markers of replication fork stalling and DNA double-strand breaks along the human genome. This analysis indicates that tran
Externí odkaz:
https://doaj.org/article/35e4cba44cab42719755eb47f371e731
Autor:
Sarah Cohen, Nadine Puget, Yea-Lih Lin, Thomas Clouaire, Marion Aguirrebengoa, Vincent Rocher, Philippe Pasero, Yvan Canitrot, Gaëlle Legube
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Recent studies suggest key roles of RNA in DNA double-strand breaks repair. Here the authors identify the helicase senataxin to be involved in DNA repair and resolve RNA:DNA hybrids forming at DNA double-strand breaks.
Externí odkaz:
https://doaj.org/article/a76ef802a4c44fb2b9db439a268bff73
Autor:
Laure Dutrieux, Yea-Lih Lin, Malik Lutzmann, Raphaël Rodriguez, Michel Cogné, Philippe Pasero, Jérôme Moreaux
Publikováno v:
Cancers, Vol 13, Iss 15, p 3755 (2021)
Plasma cells (PCs) have an essential role in humoral immune response by secretion of antibodies, and represent the final stage of B lymphocytes differentiation. During this differentiation, the pre-plasmablastic stage is characterized by highly proli
Externí odkaz:
https://doaj.org/article/858f4db326614ffc8c6bbf34740fb44d
Autor:
Nadia Bakkour, Yea-Lih Lin, Sophie Maire, Lilia Ayadi, Florence Mahuteau-Betzer, Chi Hung Nguyen, Clément Mettling, Pierre Portales, David Grierson, Benoit Chabot, Philippe Jeanteur, Christiane Branlant, Pierre Corbeau, Jamal Tazi
Publikováno v:
PLoS Pathogens, Vol 3, Iss 10, Pp 1530-1539 (2007)
The development of multidrug-resistant viruses compromises antiretroviral therapy efficacy and limits therapeutic options. Therefore, it is an ongoing task to identify new targets for antiretroviral therapy and to develop new drugs. Here, we show tha
Externí odkaz:
https://doaj.org/article/0558f3219f6644978fa4dca7b8816d1d
Autor:
Ming-Yi Shen, Yan-Jun Liu, Ming-Jaw Don, Hsien-Yueh Liu, Zeng-Weng Chen, Clément Mettling, Pierre Corbeau, Chih-Kang Chiang, Yu-Song Jang, Tzu-Hsuan Li, Paul Young, Cicero L. T. Chang, Yea-Lih Lin, Wen-Chin Yang
Publikováno v:
PLoS ONE, Vol 7, Iss 6 (2012)
Externí odkaz:
https://doaj.org/article/126120d6545b4e079cbc3e1a746e28e7