Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yea Seul Shin"'
Autor:
Malcolm K. Horne, Philip M Beart, Nirma D Perera, Yea Seul Shin, Chew L. Lau, Rebecca K. Sheean, Bradley J. Turner
Publikováno v:
Autophagy
Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -ind
Autor:
Suzanne Lesage, Philip M Beart, Adeline Muscat, Fiona Bonello, Sidi-Mohamed Hassoun, Alexis Brice, Olga Corti, François Mouton-Liger, Jean-Christophe Corvol, Christelle Tesson, Yea Seul Shin, Johannes Krupp
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2019, 28 (10), pp.1645-1660. ⟨10.1093/hmg/ddz004⟩
Human Molecular Genetics, 2019, 28 (10), pp.1645-1660. ⟨10.1093/hmg/ddz004⟩
Human Molecular Genetics, Oxford University Press (OUP), 2019, 28 (10), pp.1645-1660. ⟨10.1093/hmg/ddz004⟩
Human Molecular Genetics, 2019, 28 (10), pp.1645-1660. ⟨10.1093/hmg/ddz004⟩
International audience; Mutations of LRRK2, encoding leucine-rich repeat kinase 2 (LRRK2), are the leading cause of autosomal dominant Parkinson's disease (PD). The most frequent of these mutations, G2019S substitution, increases kinase activity, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140e626bb367ccae096121aa8242812d
https://hal.sorbonne-universite.fr/hal-02408164
https://hal.sorbonne-universite.fr/hal-02408164
Autor:
James G. Ryall, Yea Seul Shin, Phillip Nagley, Chew L. Lau, Joanne M. Britto, Philip M Beart, Rodney J. Devenish
Publikováno v:
Journal of neurochemistry. 149(2)
Contributions of damaged mitochondria to neuropathologies have stimulated interest in mitophagy. We investigated triggers of neuronal mitophagy by disruption of mitochondrial energy metabolism in primary neurons. Mitophagy was examined in cultured mu
Autor:
Erica L. Fletcher, Monica L. Acosta, Yea-Seul Shin, David L. Christie, Sarah Ready, Michael Kalloniatis
Publikováno v:
American Journal of Physiology-Cell Physiology. 298:C764-C774
We determined the metabolic changes that precede cell death in the dystrophic proline-23-histidine (P23H) line 3 (P23H-3) rat retina compared with the normal Sprague-Dawley (SD) rat retina. Metabolite levels and metabolic enzymes were analyzed early
Publikováno v:
Neuroscience. 254
Astrocytes are plastic cells that play key roles in brain physiology and pathology, including via their glutamate transporters, excitatory amino acid transporter (EAAT)1 and EAAT2, maintaining low extracellular glutamate concentrations and protecting
Autor:
Gavin C Higgins, Nam Sang Cheung, Philip M Beart, Yea Seul Shin, Phillip Nagley, Minghui Jessica Chen
Publikováno v:
Journal of Alzheimer's disease : JAD. 20
Oxidative stress plays a central role in neuronal injury and cell death in acute and chronic pathological conditions. The cellular responses to oxidative stress embrace changes in mitochondria and other organelles, notably endoplasmic reticulum, and
Autor:
Philip M Beart, Maria Lourdes Regina Hughes, Percy W.Y. Chu, Linda D Mercer, Phillip Nagley, Liubov Kardashsyan, Chew L. Lau, Yea Seul Shin, Shanti Diwakarla
Publikováno v:
Journal of neurochemistry. 109
GABAergic striatal neurons are compromised in basal ganglia pathologies and we analysed how insult nature determined their patterns of injury and recruitment of the intrinsic mitochondrial pathway during programmed cell death (PCD). Stressors affecti
Autor:
Erica L. Fletcher, Yea-Seul Shin, Sarah Ready, Michael Kalloniatis, Monica L. Acosta, David L. Christie
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C186-C187
reply: B. Winkler questions the validity of some of our conclusions in relation to a mutant model of retinitis pigmentosa (Proline-23-Histidine rat) published in a recent issue ([1][1]). He bases his objections on three issues: 1 ) Lactate dehydrogen
Autor:
Higgins, Gavin C., Beart, Philip M., Yea Seul Shin, Chen, Minghui Jessica, Nam Sang Cheung, Nagley, Phillip
Publikováno v:
Journal of Alzheimer's Disease; 2010 Supplement 2, Vol. 20, p453-473, 21p, 2 Diagrams, 1 Chart
Autor:
Acosta, Monica L., Yea-Seul Shin, Ready, Sarah, Fletcher, Erica L., Christie, David L., Kalloniatis, Michael
Publikováno v:
American Journal of Physiology: Cell Physiology; Jul2010, Vol. 299 Issue 1, pC186-C187, 2p