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Akademický článek

Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.

Autor: Yunseok Heo, Naito Ishimoto, Ye-Eun Jeon, Ji-Hye Yun, Mio Ohki, Yuki Anraku, Mina Sasaki, Shunsuke Kita, Hideo Fukuhara, Tatsuya Ikuta, Kouki Kawakami, Asuka Inoue, Katsumi Maenaka, Jeremy R H Tame, Weontae Lee, Sam-Yong Park

Publikováno v: PLoS Biology, Vol 20, Iss 8, p e3001714 (2022)

Galanin is a neuropeptide expressed in the central and peripheral nervous systems, where it regulates various processes including neuroendocrine release, cognition, and nerve regeneration. Three G-protein coupled receptors (GPCRs) for galanin have be

Externí odkaz: https://doaj.org/article/bc65a6dbb735456480e5f6dba38fabc3

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Akademický článek

Alpha-linolenic acid enhances maturation and developmental competence via regulation of glutathione, cAMP and fatty acid accumulation during in vitro maturation of porcine oocytes

Autor: Ye-Eun Jeon, Yong Hwangbo, Sun-Young Kim, Choon-Keun Park

Publikováno v: Journal of Animal Reproduction and Biotechnology, Vol 35, Iss 4, Pp 357-365 (2020)

The aim of present study was to investigate regulatory mechanism of alpha-linolenic acid (ALA) during in vitro maturation (IVM) on nuclear and cytoplasmic maturation of porcine oocytes. Basically, immature cumulus-oocyte complexes (COCs) were incubat

Externí odkaz: https://doaj.org/article/c494e3c1c5704cd48d8c8c33cad00a69

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Akademický článek

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

Autor: Yunseok Heo, Eojin Yoon, Ye-Eun Jeon, Ji-Hye Yun, Naito Ishimoto, Hyeonuk Woo, Sam-Yong Park, Ji-Joon Song, Weontae Lee

Publikováno v: eLife, Vol 11 (2022)

Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ne

Externí odkaz: https://doaj.org/article/1e26a0c604ff4fcfb233a5125dd43188

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Akademický článek

Effects of Hyaluronidase during In Vitro Maturation on Maturation and Developmental Competence in Porcine Oocytes

Autor: Ye-Eun Jeon, Yong Hwangbo, Hee-Tae Cheong, Choon-Keun Park

Publikováno v: Journal of Animal Reproduction and Biotechnology, Vol 34, Iss 2, Pp 86-92 (2019)

The aim of this study was to investigate effects of hyaluronidase during IVM on oocyte maturation, oxidative stress status, expression of cumulus expansion-related (PTX, pentraxin; GJA1, gap junction protein alpha 1; PTGS2, prostaglandin-endoperoxide

Externí odkaz: https://doaj.org/article/e23c942ebcb9497d99e4311859422c43

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