Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Ye H Oo"'
Autor:
Scott P. Davies, Vincenzo Ronca, Grace E. Wootton, Natalia M. Krajewska, Amber G. Bozward, Rémi Fiancette, Daniel A. Patten, Katharina Yankouskaya, Gary M. Reynolds, Sofia Pat, Daniel C. Osei-Bordom, Naomi Richardson, Liam M. Grover, Christopher J. Weston, Ye H. Oo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The presence of CD8+ T cells in the cytoplasm of biliary epithelial cells (BEC) has been correlated with biliary damage associated with primary biliary cholangitis (PBC). Here, we characterise the mechanism of CD8+ T cell invasion into BEC.
Externí odkaz:
https://doaj.org/article/8c5d5d80fa404d79a9d64d2f03722925
Autor:
James I. Kennedy, Scott P. Davies, Peter W. Hewett, Alex L. Wilkinson, Ye H. Oo, Wei-Yu Lu, Alicia J. El Haj, Shishir Shetty
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Immunotherapy has changed the landscape of treatment options for patients with hepatocellular cancer. Checkpoint inhibitors are now standard of care for patients with advanced tumours, yet the majority remain resistant to this therapy and urgent appr
Externí odkaz:
https://doaj.org/article/a2ab91cef8bf48c791a2da90a324bdec
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The constant exposure of the liver to gut derived foreign antigens has resulted in this organ attaining unique immunological characteristics, however it remains susceptible to immune mediated injury. Our understanding of this type of injury, in both
Externí odkaz:
https://doaj.org/article/25e272cb2fda4276ad10568ea98c3cee
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Despite major advances in immunotherapy, hepatocellular carcinoma (HCC) remains a challenging target. Natural Killer (NK) cells are crucial components of the anti-HCC immune response, which can be manipulated for immunotherapeutic benefit as primary
Externí odkaz:
https://doaj.org/article/b6f55cb9f7fb4bdc8585c3c5a7d97de7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5872 (2022)
Immune-mediated cholangiopathies are characterised by the destruction of small and large bile ducts causing bile acid stasis, which leads to subsequent inflammation, fibrosis, and eventual cirrhosis of the liver tissue. A breakdown of peripheral hepa
Externí odkaz:
https://doaj.org/article/e86c2c488f7f4a1faa7cd412b2c00e40
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The maternal immune system engages in a fine balancing act during pregnancy by simultaneously maintaining immune tolerance to the fetus and immune responses to protect against invading organisms. Pregnancy is an intricately orchestrated process where
Externí odkaz:
https://doaj.org/article/8ae54668141840a9b3b97103d0306495
Autor:
Johannes Hartl, Rosa Miquel, Kalliopi Zachou, Guan-Wee Wong, Asma Asghar, Simon Pape, Marcial Sebode, Moritz Peiseler, Roman Zenouzi, Hanno Ehlken, Till Krech, Christina Weiler-Normann, Joost P.H. Drenth, Ye H. Oo, George Nikolaos Dalekos, Michael Heneghan, Christoph Schramm, Ansgar Wilhelm Lohse
Publikováno v:
JHEP Reports, Vol 2, Iss 3, Pp - (2020)
Background & Aims: High IgG levels are considered a hallmark of autoimmune hepatitis (AIH). A subgroup of patients with AIH has IgG within the normal range despite evidence of clinical disease activity. The clinical significance of this biomarker has
Externí odkaz:
https://doaj.org/article/bcca109810554658a87eabfcfdf0b496
Autor:
Martin S. Davey, Carrie R. Willcox, Stuart Hunter, Sofya A. Kasatskaya, Ester B. M. Remmerswaal, Mahboob Salim, Fiyaz Mohammed, Frederike J. Bemelman, Dmitriy M. Chudakov, Ye H. Oo, Benjamin E. Willcox
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Human Vδ2+ γδ T cells are thought to be an innate-like T-cell population. Here the authors show the Vδ2+ compartment contains both innate-like Vγ9+ and an adaptive Vγ9- subset that undergoes clonal expansion during viral infection and can infil
Externí odkaz:
https://doaj.org/article/34013345c36840c6887dde5ba30f872e
Autor:
Philipp Lutz, Hannah C. Jeffery, Nicholas Jones, Jane Birtwistle, Benjamin Kramer, Jacob Nattermann, Ulrich Spengler, Christian P. Strassburg, David H. Adams, Ye H. Oo
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background and Aims: Ascites and spontaneous bacterial peritonitis (SBP) are frequent complications of liver cirrhosis. In spite of the clinical impact, knowledge about ascites as an immune cell compartment in liver disease is limited. Therefore, we
Externí odkaz:
https://doaj.org/article/edfa5d89f86d4f1f89fe184d014aae3f
Publikováno v:
Seminars in Immunopathology. 44:393-395