Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload

Autor: Marcel A. Vieira-Lara, Marleen B. Dommerholt, Wenxuan Zhang, Maaike Blankestijn, Justina C. Wolters, Fentaw Abegaz, Albert Gerding, Ydwine T. van der Veen, Rachel Thomas, Ronald P. van Os, Dirk-Jan Reijngoud, Johan W. Jonker, Janine K. Kruit, Barbara M. Bakker

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)

Abstract Background The skeletal muscle plays a central role in glucose homeostasis through the uptake of glucose from the extracellular medium in response to insulin. A number of factors are known to disrupt the normal response to insulin leading to

Externí odkaz: https://doaj.org/article/a9716da0b74d420cb0e3c1ac024d69e9

Age-related susceptibility to insulin resistance is due to a combination of CPT1B decline and lipid overload

Autor: Dirk-Jan Reijngoud, Barbara M. Bakker, Maaike Blankestijn, Theo H. van Dijk, Albert Gerding, Wenxuan Zhang, Johan W. Jonker, Justina C. Wolters, Janine K. Kruit, Marcel A. Vieira-Lara, Ronald van Os, Marleen B Dommerholt, Fentaw Abegaz, Ydwine T. van der Veen

BACKGROUNDAdvanced age increases the susceptibility to diet-induced insulin resistance (IR). A key driver of this phenomenon is lipid accumulation in the skeletal muscle. It is debated, however, whether this is due to dietary lipid overload or declin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bceb282d912cea16a389ec5328cecae
https://doi.org/10.1101/2021.02.04.429529

Effects of an early life diet containing large phospholipid-coated lipid globules on hepatic lipid metabolism in mice

Autor: Onne A H O, Ronda, Bert J M, van de Heijning, Ingrid, Martini, Albert, Gerding, Justina C, Wolters, Ydwine T, van der Veen, Martijn, Koehorst, Angelika, Jurdzinski, Rick, Havinga, Eline M, van der Beek, Folkert, Kuipers, Henkjan J, Verkade

Publikováno v: Scientific reports. 10(1)

We recently reported that feeding mice in their early life a diet containing a lipid structure more similar to human milk (eIMF, Nuturis) results in lower body weights and fat mass gain upon high fat feeding in later life, compared to control (cIMF).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0bb96de08e2befb546f49a151048abb
https://pubmed.ncbi.nlm.nih.gov/32999305

A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor

Autor: Freerk van Dijk, Bart van de Sluis, Marijn Riemsma, Antoine Rimbert, Justina C. Wolters, Nicolette C. A. Huijkman, Amika Singla, Marieke Smit, Anne Tybjærg-Hansen, N. Dalila, Jan Albert Kuivenhoven, Ydwine T. van der Veen, Ezra Burstein, Niels J. Kloosterhuis, Ruth Frikke-Schmidt

Publikováno v: Rimbert, A, Dalila, N, Wolters, J C, Huijkman, N, Smit, M, Kloosterhuis, N, Riemsma, M, Van Der Veen, Y, Singla, A, Van Dijk, F, Frikke-Schmidt, R, Burstein, E, Tybjærg-Hansen, A, Van De Sluis, B & Kuivenhoven, J A 2020, ' A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor ', European Heart Journal, vol. 41, no. 9, pp. 1040-1053 . https://doi.org/10.1093/eurheartj/ehz727
European Heart Journal
European Heart Journal, Oxford University Press (OUP): Policy B, 2019, ⟨10.1093/eurheartj/ehz727⟩
European Heart Journal, 41(9), 1040-1053. Oxford University Press

Aims Genome-wide association studies have previously identified INSIG2 as a candidate gene for plasma low-density lipoprotein cholesterol (LDL-c). However, we suspect a role for CCDC93 in the same locus because of its involvement in the recycling of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2dc23f2619a98b5201e5561b72dfda
https://pubmed.ncbi.nlm.nih.gov/31834377