Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yazi Wei"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 10, Pp 4185-4201 (2023)
Monocytes are key effectors in autoimmunity-related diseases in the central nervous system (CNS) due to the critical roles of these cells in the production of proinflammatory cytokines, differentiation of T-helper (Th) cells, and antigen presentation
Externí odkaz:
https://doaj.org/article/f2d2564b1d84477dbba54b4abba92457
Autor:
Gaona Shi, Yu Zhou, Wenshuai Liu, Chengjuan Chen, Yazi Wei, Xinlong Yan, Lei Wu, Weiwei Wang, Lan Sun, Tiantai Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2778-2794 (2023)
Tolerogenic dendritic cells (tolDCs) facilitate the suppression of autoimmune responses by differentiating regulatory T cells (Treg). The dysfunction of immunotolerance results in the development of autoimmune diseases, such as rheumatoid arthritis (
Externí odkaz:
https://doaj.org/article/29fdddd46e6440ee884d46b379a326f3
Publikováno v:
Evidence-Based Complementary and Alternative Medicine. 2023:1-10
Xuelian, as a traditional Chinese ethnodrug, plays an important role in anti-inflammation, immunoregulation, promoting blood circulation, and other physiological functions. It has been prepared into different traditional Chinese medicine preparations
Publikováno v:
Chinese Chemical Letters. 33:5047-5050
Autor:
Yu Zhou, Manru Li, Tao Shen, Tianming Yang, Gaona Shi, Yazi Wei, Chengjuan Chen, Dongmei Wang, Yanan Wang, Tiantai Zhang
Publikováno v:
ACS Chemical Biology. 17:2734-2743
Celastrol (CEL), a pentacyclic triterpene compound, has been proven to have a definite antipulmonary fibrosis effect. However, its direct targets for antipulmonary fibrosis remain unknown. In this study, we designed and synthesized a series of celast
Autor:
Chengjuan Chen, Yuan Yin, Gaona Shi, Yu Zhou, Shuai Shao, Yazi Wei, Lei Wu, Dayong Zhang, Lan Sun, Tiantai Zhang
Publikováno v:
Science Advances. 8
Janus kinases (JAKs) play a critical role in immune responses by relaying signals from more than 50 cytokines, making them attractive therapeutic targets for autoimmune diseases. Although approved JAK inhibitors have demonstrated clinical efficacy, t
Autor:
Yan Yang, Tiantai Zhang, Chengjuan Chen, Shuai Shao, Yazi Wei, Lei Wu, Yu Zhou, Gaona Shi, Ningyu Fan
Publikováno v:
Pharmacology & Therapeutics. 227:107880
Inflammasomes are multi-protein macromolecular complexes that typically comprise of three units, a sensor, an adaptor and procaspase-1. The assembly of each inflammasome is dictated by a unique pattern recognition receptors (PRRs) in response to path