Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yayoi Kishimoto"'
Autor:
Thomas R. Shearer, Chiho Yabuta, Seiko Kozai, Mitsuyoshi Azuma, Yayoi Kishimoto, Ayumi Mori, Akira Ohtori
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 33(7)
To establish the in silico ocular pharmacokinetic modeling for eye drops, and to simulate the dose regimen for FK962 in human choroid/retinal diseases.Pharmacokinetics for FK962 in vivo was performed by a single instillation of drops containing 0.1%T
Publikováno v:
Life Sciences. 64:PL1-PL7
We previously reported that the morphine-induced place preference was attenuated under inflammation produced by the unilateral injection of 2.5 % formalin (50 microl) into the hind paw of rats. In the present study, to elucidate the mechanism of this
Autor:
Jun Maeda, Miwa Misawa, Minoru Tsuji, Tsutomu Suzuki, Hiroshi Nagase, Yayoi Kishimoto, Tomohisa Mori
Publikováno v:
European Journal of Pharmacology. 324:21-29
The effects of selective μ-, δ- and κ-opioid receptor agonists on the discriminative stimulus properties of cocaine were examined in rats trained to discriminate between cocaine (10 mg/kg) and saline. Cocaine produced a dose-related increase in co
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 30(1)
Recent clinical studies have demonstrated that when morphine is used to control pain in cancer patients, psychological dependence is not a major concern. The present study was undertaken to ascertain the modulation of psychological dependence on morp
Autor:
Satoshi Imai, Kousei Oe, Masami Suzuki, Michiko Narita, Minoru Narita, Tsutomu Suzuki, Satoru Ozaki, Yoshinori Yajima, Yayoi Kishimoto, Mitsuaki Yamazaki
Publikováno v:
Life sciences. 74(21)
In the present study, we demonstrated whether a neuropathic pain-like state induced by sciatic nerve ligation in rodents could cause a long-lasting change in intracellular signaling in both supraspinal and spinal cord related to the suppression of mo
Publikováno v:
European journal of pain (London, England). 5
Clinical studies have demonstrated that when opiates are used to control cancer pain, psychological dependence and analgesic tolerance are not a major concern. The present study was, therefore, designed to investigate the modulation of rewarding effe
Publikováno v:
Life sciences. 59(19)
Morphine-, methamphetamine- and cocaine-induced place preferences under inflammation produced by unilateral injections of 2.5% formalin (50 microliters) and 1% carrageenan (100 microliters) into the hind paw were examined in rats. Formalin and carrag
Publikováno v:
Investigative Opthalmology & Visual Science. 53:5312
Purpose Amputation of the trigeminal nerve leads to decreased corneal sensitivity and dry eye. Our previous study showed that the drug FK962 (N-[1-acetylpiperidin-4-yl]-4-fluorobenzamide) induced neurite elongation from trigeminal ganglion (TG) cells
Autor:
Akira Ohtori, Mitsuyoshi Azuma, Takayuki Oka, Chiho Yabuta, Ayumi Yoshimatsu, Yayoi Kishimoto
Publikováno v:
American Journal of Ophthalmology. 153:651-660.e1
Purpose To test if the drug FK962 (N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide) facilitates axonal elongation and recovery of corneal sensitivity after creation of a corneal flap in rabbits. Design Animal study. Methods Primary cultures of rabbit tr
Publikováno v:
Japanese Journal of Pharmacology. 71:89