Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Yayoi Kinoshita"'
Autor:
Esra Karakose, Huan Wang, William Inabnet, Rajesh V. Thakker, Steven Libutti, Gustavo Fernandez-Ranvier, Hyunsuk Suh, Mark Stevenson, Yayoi Kinoshita, Michael Donovan, Yevgeniy Antipin, Yan Li, Xiaoxiao Liu, Fulai Jin, Peng Wang, Andrew Uzilov, Carmen Argmann, Eric E. Schadt, Andrew F. Stewart, Donald K. Scott, Luca Lambertini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Insulinomas are rare, benign beta cell tumours which overproduce insulin and have been associated to epigenetic alterations. Here the authors characterise insulinoma methylomes, finding changes in promoter methylation and chromatin structure proposed
Externí odkaz:
https://doaj.org/article/1d219e060ef14af69f480f879ef60196
Autor:
Huan Wang, Aaron Bender, Peng Wang, Esra Karakose, William B. Inabnet, Steven K. Libutti, Andrew Arnold, Luca Lambertini, Micheal Stang, Herbert Chen, Yumi Kasai, Milind Mahajan, Yayoi Kinoshita, Gustavo Fernandez-Ranvier, Thomas C. Becker, Karen K. Takane, Laura A. Walker, Shira Saul, Rong Chen, Donald K. Scott, Jorge Ferrer, Yevgeniy Antipin, Michael Donovan, Andrew V. Uzilov, Boris Reva, Eric E. Schadt, Bojan Losic, Carmen Argmann, Andrew F. Stewart
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Diabetes results in part from a deficiency of functional pancreatic beta cells. Here, the authors study the genomic and epigenetic landscapes of human insulinomas to gain insight into possible pathways for therapeutic beta cell regeneration, highligh
Externí odkaz:
https://doaj.org/article/80c3e45c47014686a61554de1f26c1c1
Autor:
Guang-Qian Xiao, Pamela Unger, Qi Yang, Yayoi Kinoshita, Kyra Singh, Loralee McMahon, Kent Nastiuk, Kai Sha, John Krolewski, David Burstein
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121318 (2015)
PLZF is a transcription repressor, which plays a critical role in development, spermatogenesis and oncogenesis. Down-regulation of PLZF has been found in various tumor cell lines. There has been virtually no tissue study on the expression of PLZF in
Externí odkaz:
https://doaj.org/article/31f6bac41e4648e9b5818f06acc69fba
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36137 (2012)
The shape of nuclei in many adherent cultured cells approximates an oblate ellipsoid, with contralateral flattened surfaces facing the culture plate or the medium. Observations of cultured cell nuclei from orthogonal perspectives revealed that nucleo
Externí odkaz:
https://doaj.org/article/026616de54644f35b876779f73a243eb
Autor:
Jonathan T, Dullea, Vikram, Vasan, John W, Rutland, Corey M, Gill, Danielle, Chaluts, Daniel, Ranti, Ethan, Ellis, Varun, Subramanium, Annie, Arrighi-Allisan, Yayoi, Kinoshita, Russell B, McBride, Joshua, Bederson, Michael, Donovan, Robert, Sebra, Melissa, Umphlett, Raj K, Shrivastava
Publikováno v:
Oncoscience. 9:70-81
Meningiomas are common intracranial tumors with variable prognoses not entirely captured by commonly used classification schemes. We sought to determine the relationship between meningioma mutations and oncologic outcomes using a targeted next-genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6e2a823588c9ce82332bb59dfe2299
https://doi.org/10.18632/oncoscience.570
https://doi.org/10.18632/oncoscience.570
Autor:
Vikram Vasan, Jonathan T. Dullea, Alex Devarajan, Muhammad Ali, John W. Rutland, Corey M. Gill, Yayoi Kinoshita, Russell B. McBride, Paul Gliedman, Joshua Bederson, Michael Donovan, Robert Sebra, Melissa Umphlett, Raj K. Shrivastava
Publikováno v:
Journal of neuro-oncology.
High grade meningiomas have a prognosis characterized by elevated recurrence rates and radiation resistance. Recent work has highlighted the importance of genomics in meningioma prognostication. This study aimed to assess the relationship between the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2378ddae35bcc1ff55dd7fad29444284
https://pubmed.ncbi.nlm.nih.gov/36436149
https://pubmed.ncbi.nlm.nih.gov/36436149
Autor:
Danielle Chaluts, Jonathan T. Dullea, Muhammad Ali, Vikram Vasan, Alex Devarajan, John W. Rutland, Corey M. Gill, Ethan Ellis, Yayoi Kinoshita, Russell B. McBride, Joshua Bederson, Michael Donovan, Robert Sebra, Melissa Umphlett, Raj K. Shrivastava
Publikováno v:
Journal of cancer research and clinical oncology.
The oncologic outcomes for atypical meningiomas can be poor. Generally, patients that have had a prior recurrence have a substantially elevated risk of a future recurrence. Additionally, certain tumor genomic profiles have been shown as markers of po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231258170eb8dde46a8ffa8ab947eb14
https://pubmed.ncbi.nlm.nih.gov/36348021
https://pubmed.ncbi.nlm.nih.gov/36348021
Autor:
Margaret Pain, Joshua B. Bederson, Melissa Umphlett, Yayoi Kinoshita, Michael J. Donovan, John W. Rutland, Joshua Loewenstern, Mary Fowkes, Raj K. Shrivastava, Hanane Arib, Corey M. Gill, Russell B. McBride, Robert Sebra
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 147:3431-3440
While SWI/SNF chromatin remodeling complex alterations occur in approximately 20% of cancer, the frequency and potential impact on clinical outcomes in meningiomas remains to be comprehensively elucidated. A large series of 255 meningiomas from a sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a53c736fd216637a84ff8e1468751f4a
https://doi.org/10.1007/s00432-021-03586-7
https://doi.org/10.1007/s00432-021-03586-7
Autor:
John W. Rutland, Mary Fowkes, Yayoi Kinoshita, Margaret Pain, Joshua B. Bederson, Melissa Umphlett, Russell B. McBride, Robert Sebra, Raj K. Shrivastava, Hanane Arib, Corey M. Gill, Michael J. Donovan, Joshua Loewenstern
Publikováno v:
Neuroradiology. 63:73-80
Meningiomas are the most common primary central nervous system tumor. Emerging data supports that higher mutational burden portends worse clinical outcomes in meningiomas. However, there is a lack of imaging biomarkers that are associated with tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6254435e0f46117edff52ef44b82732
https://doi.org/10.1007/s00234-020-02515-8
https://doi.org/10.1007/s00234-020-02515-8
Autor:
Joshua Loewenstern, Robert Sebra, Margaret Pain, Melissa Umphlett, Mary Fowkes, Joshua B. Bederson, John W. Rutland, Russell B. McBride, Yayoi Kinoshita, Michael J. Donovan, Raj K. Shrivastava, Hanane Arib, Corey M. Gill
Publikováno v:
Cancer Immunology, Immunotherapy. 70:169-176
The tumor microenvironment is an emerging biomarker of underlying genomic heterogeneity and response to immunotherapy-based treatment regimens in solid malignancies. How tumor mutational burden influences the density, distribution, and presence of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5bdb70b3687224a7456f90fd75bfe13
https://doi.org/10.1007/s00262-020-02671-z
https://doi.org/10.1007/s00262-020-02671-z