Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yayoi Kawata"'
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundThis study aimed to determine real-world prescribing patterns and determinants for Japanese patients with Parkinson's disease (PD), with a focus on patients ≥75 years.MethodsThis was a retrospective, observational, longitudinal study of p
Externí odkaz:
https://doaj.org/article/cfce3a23ad2c4557989e22ae9b726e9c
Publikováno v:
Heliyon, Vol 8, Iss 2, Pp e08889- (2022)
Aims: Pyruvate dehydrogenase (PDH) catalyzes the decarboxylation of pyruvate to acetyl-CoA, which plays a key role in linking cytosolic glycolysis to mitochondria metabolism. PDH is physiologically inactivated by pyruvate dehydrogenase kinases (PDKs)
Externí odkaz:
https://doaj.org/article/42a7338c8fe24cb38aa8a54d8c4c0604
Autor:
Nobutaka Hattori, Yoshiko Okada, Yayoi Kawata, Yoshihiko Furusawa, Takumi Imai, Hisako Yoshida, Mihoko Ota, Masaki Arai, Ayumi Shintani, Jovelle Fernandez
Publikováno v:
Patient Preference and Adherence.
Nobutaka Hattori,1 Yoshiko Okada,2 Yayoi Kawata,3 Yoshihiko Furusawa,3 Takumi Imai,4 Hisako Yoshida,4 Mihoko Ota,3 Masaki Arai,3 Ayumi Shintani,4 Jovelle Fernandez3 1Department of Neurology, Juntendo University, Tokyo, Japan; 2Japan Parkinson Congres
Publikováno v:
Proceedings of PICMET'22 Conference: Portland International Center for Management of Engineering and Technology.
Autor:
Taiji Asami, Tetsuya Ohtaki, Shiro Takekawa, Yayoi Kawata, Kotaro Sakamoto, Yasushi Masuda, Tadashi Umemoto, Takashi Ito, Hiroshi Inooka
Publikováno v:
Biochemical and Biophysical Research Communications. 480:55-60
Fibroblast growth factor receptor-1c (FGFR1c)/βKlotho (KLB) complex is a receptor of fibroblast growth factor 21 (FGF21). Pharmacologically, FGF21 shows anti-obesity and anti-diabetic effects upon peripheral administration. Here, we report the devel
Autor:
Uttam Khamrai, Jumpei Aida, Mrinalkanti Kundu, Tsuneo Yasuma, Mikio Shirasaki, Shoki Okuda, Shizuo Kasai, Syunsuke Yamamoto, Asato Kina, Masashi Takahashi, Toshihiro Noguchi, Yasutaka Nagisa, Yayoi Kawata, Hideyuki Igawa, Minoru Ikoma, Yasushi Fujioka, Keiko Kakegawa, Tsuyoshi Maekawa, Masaharu Nakayama
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2486-2503
Melanin-concentrating hormone (MCH) is an attractive target for antiobesity agents, and numerous drug discovery programs are dedicated to finding small-molecule MCH receptor 1 (MCHR1) antagonists. We recently reported novel pyridine-2(1 H )-ones as a
Autor:
Shoki Okuda, Minoru Ikoma, Masashi Takahashi, Shizuo Kasai, Yasutaka Nagisa, Hiromi Kaku, Syunsuke Yamamoto, Tsuyoshi Maekawa, Toshihiro Noguchi, Asato Kina, Keiko Kakegawa, Natsu Hotta, Yayoi Kawata, Hideyuki Igawa, Jumpei Aida, Masaharu Nakayama
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2504-2518
To develop non-basic melanin-concentrating hormone receptor 1 (MCHR1) antagonists with a high probability of target selectivity and therapeutic window, we explored neutral bicyclic motifs that could replace the previously reported imidazo[1,2-a]pyrid
Autor:
Hideyuki Igawa, Masashi Takahashi, Minoru Ikoma, Shiro Takekawa, Ayumi Ando, Shizuo Kasai, Natsu Hotta, Masaharu Nakayama, Mayumi Nishida, Shoki Okuda, Yoshinori Satomi, Yasutaka Nagisa, Syunsuke Yamamoto, Yayoi Kawata
Publikováno v:
European journal of pharmacology. 796
Melanin-concentrating hormone (MCH), a cyclic neuropeptide expressed predominantly in the lateral hypothalamus, plays an important role in the control of feeding behavior and energy homeostasis. Mice lacking MCH or MCH1 receptor are resistant to diet
Autor:
Uttam Khamrai, Shizuo Kasai, Minoru Ikoma, Asato Kina, Masaharu Nakayama, Jumpei Aida, Keiko Kakegawa, Yasutaka Nagisa, Masashi Takahashi, Syunsuke Yamamoto, Hideki Hirabayashi, Tsuneo Yasuma, Hideyuki Igawa, Mrinalkanti Kundu, Yayoi Kawata, Tsuyoshi Maekawa, Shuntaro Ashina
Publikováno v:
Journal of medicinal chemistry. 59(3)
Aiming to discover melanin-concentrating hormone receptor 1 (MCHR1) antagonists with improved safety profiles, we hypothesized that the aliphatic amine employed in most antagonists reported to date could be removed if the bicyclic motif of the compou
Publikováno v:
Lipids. 43:125-131
Liver and intestine are major sites of apo A-I synthesis in mammals. ABCAI is reported to be involved in the secretion of nascent HDL from cultured intestinal cells. However, whether ABCA1 participates in the secretion of nascent HDL from the intesti