Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Yaxiao Gong"'
Autor:
Yaxiao Gong, Hongbin Zhang, Zhuo Chen, Liang Gong, Guogang Deng, Bei Zhou, Dongmei Wu, Xiao-Dong Yang, Jing Wang, Yan Li
Publikováno v:
European Journal of Medicinal Chemistry. 168:232-252
Sixty-one novel steroidal imidazolium salt derivatives were synthesized and evaluated in vitro against a panel of human tumor cell lines. The results showed that diosgenin‒imidazolium salt derivatives displayed much higher cytotoxic activities than
Autor:
Tao An, Ling-Mei Kong, Chunlei Yu, Hongyu Zhou, Juming Yan, Hongbin Zhang, Liang Gong, Huifang Zhu, Xiao-Liang Xu, Yaxiao Gong, Yan Li, Ying-Chao Li, Xiao-Dong Yang
Publikováno v:
Oncogene
Cancer stem cells (CSCs) have been implicated in metastasis, relapse, and therapeutic resistance of cancer, so successful cancer therapy may therefore require the development of drugs against CSCs or combining anti-CSCs drugs with conventional therap
Autor:
Liang Gong, Yaxiao Gong, Jing-Feng Zhao, Xiao-Dong Yang, Yan Li, Hongbin Zhang, Dongmei Wu, Wu Mingjiang, Jingbo Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2543-2549
Sixty novel allogibberic acid derivatives containing 1,2,3-triazole pharmacophore were designed and synthesized. The key chemical processes include aromatization of the A ring in gibberellins, formation of allogibberic azides and its copper mediated
Autor:
Yaxiao Gong, Tao An, Bingyu Mao, Liang Gong, Jianmei Liu, Xue Li, Chunlei Yu, Hongyu Zhou, Pengcheng Ma, Yan Li, Ling-Mei Kong, Huifang Zhu
Publikováno v:
Biochemical Pharmacology. 131:29-39
Aberrant activation of Wnt/β-catenin signaling is closely associated with the development of various human cancers, especially colorectal cancers (CRC). The ubiquitin proteasome system (UPS) is essential in the regulation of Wnt signaling and inhibi
Autor:
Han-Dong Sun, Yaxiao Gong, Yan Li, Zhangxun Zhao, Bin Wang, Gentao Li, Liang Gong, Huifang Zhu, Tao An, Ling-Mei Kong, Hongyu Zhou, Pema-Tenzin Puno
Publikováno v:
Cell Chemical Biology. 26:1122-1132.e6
Summary Natural killer (NK) cells play a crucial role in the surveillance of malignant cells. The engagement of NK group 2 member D (NKG2D) receptor with its ligands on target cells represents a promising therapeutic strategy against cancers. Here, w