Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Yaxia Yuan"'
Autor:
Xue Yang, Zexuan Liu, Weiwei Tang, Uday P. Pratap, Alexia B. Collier, Kristin A. Altwegg, Rahul Gopalam, Xiaonan Li, Yaxia Yuan, Daohong Zhou, Zhao Lai, Yidong Chen, Gangadhara R. Sareddy, Philip T. Valente, Edward R. Kost, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2136-2156 (2024)
Endometrial carcinoma (ECa) is the fourth most common cancer among women. The oncogene PELP1 is frequently overexpressed in a variety of cancers, including ECa. We recently generated SMIP34, a small‐molecule inhibitor of PELP1 that suppresses PELP1
Externí odkaz:
https://doaj.org/article/004752a72a024ab7b87a815d9b033c3e
Autor:
Digant Nayak, Dongwen Lv, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Anindita Nayak, Eliza A. Ruben, Zongyang Lv, Patrick Sung, Robert Hromas, Guangrong Zheng, Daohong Zhou, Shaun K. Olsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved pot
Externí odkaz:
https://doaj.org/article/4bf39db45fce4580a5d76e6623bf229c
Autor:
Shurong Hou, Zhenzhen Li, Xiaoling Chen, Wenxin Wang, Ting Duan, Louis Scampavia, Yaxia Yuan, Timothy P. Spicer, Xiabin Chen, Tian Xie
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/157943dffabf466b9d6667c6532ef133
Autor:
Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng, Daohong Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectivel
Externí odkaz:
https://doaj.org/article/38d97353bbbf41e4aa6eb4a5907c3bd4
Autor:
Yonghan He, Sajid Khan, Zhiguang Huo, Dongwen Lv, Xuan Zhang, Xingui Liu, Yaxia Yuan, Robert Hromas, Mingjiang Xu, Guangrong Zheng, Daohong Zhou
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-24 (2020)
Abstract Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI). PROTACs are potentially superior to conventional small molecule inhibit
Externí odkaz:
https://doaj.org/article/d50c64223d3741a28884e3b3aee78b69
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Microsomal prostaglandin E2 synthase-1 (mPGES-1) is known as an ideal target for next generation of anti-inflammatory drugs without the side effects of currently available anti-inflammatory drugs. However, there has been no clinically promis
Externí odkaz:
https://doaj.org/article/6b1699a55ab84411a029ef331c7ca2c5
Autor:
Yonghan He, Xuan Zhang, Jianhui Chang, Ha-Neui Kim, Peiyi Zhang, Yingying Wang, Sajid Khan, Xingui Liu, Xin Zhang, Dongwen Lv, Lin Song, Wen Li, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Yuma T. Ortiz, Vivekananda Budamagunta, Jennifer H. Elisseeff, Judith Campisi, Maria Almeida, Guangrong Zheng, Daohong Zhou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity. Here, the authors generated a Bcl-xl proteolysis-targeting chimera (PROTAC) senolytic, whi
Externí odkaz:
https://doaj.org/article/dc8e747a1c2b46fbb1cf6eb91566a85f
Autor:
Matthew J Strauss, Katherine D Porter, Pamela M Quizon, Sarah E Davis, Steven Lin, Yaxia Yuan, Gustavo A Martinez-Muniz, Wei-Lun Sun, Chang-Guo Zhan, Jun Zhu
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0275182 (2022)
Dysregulation of dopaminergic transmission induced by the HIV-1 transactivator of transcription (Tat) has been implicated as a central factor in the development of HIV-1 associated neurocognitive disorders (HAND). We have demonstrated that the tyrosi
Externí odkaz:
https://doaj.org/article/3d2d1cd926a0486a8ee08f73ad1e0ddd
Autor:
Bo Zhou, Yaxia Yuan, Le Shi, Sheng Hu, Dong Wang, Yang Yang, Yuanhu Pan, Dexin Kong, Alexander N. Shikov, Pierre Duez, Moonsoo Jin, Xiaohua Li, Xuebo Hu
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Obesity is characterized by an excessive body mass, but is also closely associated with metabolic syndrome. And, so far, only limited pharmacological treatments are available for obesity management. Celastrol, a pentacyclic triterpenoid from a tradit
Externí odkaz:
https://doaj.org/article/28059d89d241477ab461cf58f06e962e
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
With the rapid development of systems-based pharmacology and poly-pharmacology, method development for rational design of multi-target drugs has becoming urgent. In this paper, we present the first de novo multi-target drug design program LigBuilder
Externí odkaz:
https://doaj.org/article/9c7abdfd3b8444d0adcf5909b9a2d2a8